Qui non proficit, deficit: Experimental models for 'integrative' research of affective disorders

Justin L. LaPorte; Rupert J. Egan; Peter C. Hart; Carisa L. Bergner; Jonathan M. Cachat; Peter R. Canavello; Allan V. Kalueff

doi:10.1016/j.jad.2009.04.010

Qui non proficit, deficit: Experimental models for 'integrative' research of affective disorders

Justin L. LaPorte
, Rupert J. Egan
, Peter C. Hart
, Carisa L. Bergner
, Jonathan M. Cachat
, Peter R. Canavello
, Allan V. Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

28 Citations (Scopus)

Abstract

Experimental models are an important tool for the study of biological mechanisms of psychiatric disorders. Although encouraging progress has been made in biological psychiatry of affective disorders, there remain numerous methodological, conceptual, and translational challenges in this field. Mounting clinical data support the view that psychiatric disorders as spectra, rather than as discrete or isolated illnesses. This requires new theories as well as new animal paradigms for "integrative" modeling of psychiatric disorders and their spectra. Here we discuss recent "integrative" experimental models and concepts that promise to advance translational research of affective disorders.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Journal of Affective Disorders
Volume	121
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jad.2009.04.010
Publication status	Published - Feb 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Affective disorders
Experimental models
Gene × environment × behavior interactions
Translational research

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10.1016/j.jad.2009.04.010

Cite this

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title = "Qui non proficit, deficit: Experimental models for 'integrative' research of affective disorders",

abstract = "Experimental models are an important tool for the study of biological mechanisms of psychiatric disorders. Although encouraging progress has been made in biological psychiatry of affective disorders, there remain numerous methodological, conceptual, and translational challenges in this field. Mounting clinical data support the view that psychiatric disorders as spectra, rather than as discrete or isolated illnesses. This requires new theories as well as new animal paradigms for {"}integrative{"} modeling of psychiatric disorders and their spectra. Here we discuss recent {"}integrative{"} experimental models and concepts that promise to advance translational research of affective disorders.",

keywords = "Affective disorders, Experimental models, Gene × environment × behavior interactions, Translational research",

author = "LaPorte, \{Justin L.\} and Egan, \{Rupert J.\} and Hart, \{Peter C.\} and Bergner, \{Carisa L.\} and Cachat, \{Jonathan M.\} and Canavello, \{Peter R.\} and Kalueff, \{Allan V.\}",

year = "2010",

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doi = "10.1016/j.jad.2009.04.010",

language = "English",

volume = "121",

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T2 - Experimental models for 'integrative' research of affective disorders

AU - LaPorte, Justin L.

AU - Egan, Rupert J.

AU - Hart, Peter C.

AU - Bergner, Carisa L.

AU - Cachat, Jonathan M.

AU - Canavello, Peter R.

AU - Kalueff, Allan V.

PY - 2010/2

Y1 - 2010/2

N2 - Experimental models are an important tool for the study of biological mechanisms of psychiatric disorders. Although encouraging progress has been made in biological psychiatry of affective disorders, there remain numerous methodological, conceptual, and translational challenges in this field. Mounting clinical data support the view that psychiatric disorders as spectra, rather than as discrete or isolated illnesses. This requires new theories as well as new animal paradigms for "integrative" modeling of psychiatric disorders and their spectra. Here we discuss recent "integrative" experimental models and concepts that promise to advance translational research of affective disorders.

AB - Experimental models are an important tool for the study of biological mechanisms of psychiatric disorders. Although encouraging progress has been made in biological psychiatry of affective disorders, there remain numerous methodological, conceptual, and translational challenges in this field. Mounting clinical data support the view that psychiatric disorders as spectra, rather than as discrete or isolated illnesses. This requires new theories as well as new animal paradigms for "integrative" modeling of psychiatric disorders and their spectra. Here we discuss recent "integrative" experimental models and concepts that promise to advance translational research of affective disorders.

KW - Affective disorders

KW - Experimental models

KW - Gene × environment × behavior interactions

KW - Translational research

UR - https://www.scopus.com/pages/publications/72449161087

U2 - 10.1016/j.jad.2009.04.010

DO - 10.1016/j.jad.2009.04.010

M3 - Review article

C2 - 19428115

AN - SCOPUS:72449161087

SN - 0165-0327

VL - 121

SP - 1

EP - 9

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 1-2

ER -

Qui non proficit, deficit: Experimental models for 'integrative' research of affective disorders

Abstract

UN SDGs

Keywords

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