Preparation, characterization and biological evaluation of azido-seconucleoside analogues

Objective: To synthetize 2′,3′-azido-2′,3′- seconucleoside analogues, and to determine the potential antiviral activity. Methods: The target compounds were synthesized from natural nucleosides, through sulfonylation at 2′,3′-OH and nucleophilic substitution by NaN ₃. Results and Conclusion: The structures of these compounds were confirmed by ¹H NMR, ¹³C NMR and HRMS analyses. All the target compounds showed moderate anti-HSV-I activity, which might contribute to the research on SAR of nucleosides analogues in this field.