Potent transglutaminase inhibitors, dithio β-aminoethyl ketones

Shoichiro Ozaki; Etsuko Ebisui; Kozo Hamada; Akinobu Z. Suzuki; Akiko Terauchi; Katsuhiko Mikoshiba

doi:10.1016/j.bmcl.2010.10.136

Potent transglutaminase inhibitors, dithio β-aminoethyl ketones

Shoichiro Ozaki
, Etsuko Ebisui
, Kozo Hamada
, Akinobu Z. Suzuki
, Akiko Terauchi
, Katsuhiko Mikoshiba^*

^*Corresponding author for this work

RIKEN
JST

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Potent transglutaminase inhibitors were obtained from disulfide compounds, cystamine, dimethyl cystine, and dimethyl homocystine. The disulfide bond and thiophene ring play an important role in inhibitory activity of synthesized aryl β-amino ketones.

Original language	English
Pages (from-to)	377-379
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2010.10.136
Publication status	Published - 1 Jan 2011
Externally published	Yes

Keywords

Alzheimer's disease
Celiac disease
Dithio β-aminoethyl ketones
Huntington's disease
Parkinson's disease
Transglutaminase inhibitors

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10.1016/j.bmcl.2010.10.136

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title = "Potent transglutaminase inhibitors, dithio β-aminoethyl ketones",

abstract = "Potent transglutaminase inhibitors were obtained from disulfide compounds, cystamine, dimethyl cystine, and dimethyl homocystine. The disulfide bond and thiophene ring play an important role in inhibitory activity of synthesized aryl β-amino ketones.",

keywords = "Alzheimer's disease, Celiac disease, Dithio β-aminoethyl ketones, Huntington's disease, Parkinson's disease, Transglutaminase inhibitors",

author = "Shoichiro Ozaki and Etsuko Ebisui and Kozo Hamada and Suzuki, \{Akinobu Z.\} and Akiko Terauchi and Katsuhiko Mikoshiba",

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doi = "10.1016/j.bmcl.2010.10.136",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Potent transglutaminase inhibitors, dithio β-aminoethyl ketones

AU - Ozaki, Shoichiro

AU - Ebisui, Etsuko

AU - Hamada, Kozo

AU - Suzuki, Akinobu Z.

AU - Terauchi, Akiko

AU - Mikoshiba, Katsuhiko

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Potent transglutaminase inhibitors were obtained from disulfide compounds, cystamine, dimethyl cystine, and dimethyl homocystine. The disulfide bond and thiophene ring play an important role in inhibitory activity of synthesized aryl β-amino ketones.

AB - Potent transglutaminase inhibitors were obtained from disulfide compounds, cystamine, dimethyl cystine, and dimethyl homocystine. The disulfide bond and thiophene ring play an important role in inhibitory activity of synthesized aryl β-amino ketones.

KW - Alzheimer's disease

KW - Celiac disease

KW - Dithio β-aminoethyl ketones

KW - Huntington's disease

KW - Parkinson's disease

KW - Transglutaminase inhibitors

UR - https://www.scopus.com/pages/publications/78650515365

U2 - 10.1016/j.bmcl.2010.10.136

DO - 10.1016/j.bmcl.2010.10.136

M3 - Article

C2 - 21134746

AN - SCOPUS:78650515365

SN - 0960-894X

VL - 21

SP - 377

EP - 379

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Potent transglutaminase inhibitors, dithio β-aminoethyl ketones

Abstract

Keywords

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