Potent transglutaminase inhibitors, aryl β-aminoethyl ketones

Shoichiro Ozaki; Etsuko Ebisui; Kozo Hamada; Jun Ichi Goto; Akinobu Z. Suzuki; Akiko Terauchi; Katsuhiko Mikoshiba

doi:10.1016/j.bmcl.2009.12.011

Potent transglutaminase inhibitors, aryl β-aminoethyl ketones

Shoichiro Ozaki, Etsuko Ebisui, Kozo Hamada, Jun Ichi Goto, Akinobu Z. Suzuki, Akiko Terauchi, Katsuhiko Mikoshiba^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Aryl β-aminoethyl ketones were discovered as potent inhibitors of tissue transglutaminase. Heteroaryl-like thiophene groups and N-benzyl N-t-butyl aminoethyl group are critical to the strong inhibitory activity of aryl β-aminoethyl ketones.

Original language	English
Pages (from-to)	1141-1144
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2009.12.011
Publication status	Published - 1 Feb 2010
Externally published	Yes

Keywords

Alzheimer's disease
Celiac disease
Huntington's disease
Parkinson's disease
Protein cross-link inhibitor
Transglutaminase inhibitor

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10.1016/j.bmcl.2009.12.011

Cite this

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abstract = "Aryl β-aminoethyl ketones were discovered as potent inhibitors of tissue transglutaminase. Heteroaryl-like thiophene groups and N-benzyl N-t-butyl aminoethyl group are critical to the strong inhibitory activity of aryl β-aminoethyl ketones.",

keywords = "Alzheimer's disease, Celiac disease, Huntington's disease, Parkinson's disease, Protein cross-link inhibitor, Transglutaminase inhibitor",

author = "Shoichiro Ozaki and Etsuko Ebisui and Kozo Hamada and Goto, \{Jun Ichi\} and Suzuki, \{Akinobu Z.\} and Akiko Terauchi and Katsuhiko Mikoshiba",

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AU - Ozaki, Shoichiro

AU - Ebisui, Etsuko

AU - Hamada, Kozo

AU - Goto, Jun Ichi

AU - Suzuki, Akinobu Z.

AU - Terauchi, Akiko

AU - Mikoshiba, Katsuhiko

PY - 2010/2/1

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N2 - Aryl β-aminoethyl ketones were discovered as potent inhibitors of tissue transglutaminase. Heteroaryl-like thiophene groups and N-benzyl N-t-butyl aminoethyl group are critical to the strong inhibitory activity of aryl β-aminoethyl ketones.

AB - Aryl β-aminoethyl ketones were discovered as potent inhibitors of tissue transglutaminase. Heteroaryl-like thiophene groups and N-benzyl N-t-butyl aminoethyl group are critical to the strong inhibitory activity of aryl β-aminoethyl ketones.

KW - Alzheimer's disease

KW - Celiac disease

KW - Huntington's disease

KW - Parkinson's disease

KW - Protein cross-link inhibitor

KW - Transglutaminase inhibitor

UR - https://www.scopus.com/pages/publications/74049137148

U2 - 10.1016/j.bmcl.2009.12.011

DO - 10.1016/j.bmcl.2009.12.011

M3 - Article

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AN - SCOPUS:74049137148

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -

Potent transglutaminase inhibitors, aryl β-aminoethyl ketones

Abstract

Keywords

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