Phosphinic acids: current status and potential for drug discovery

Moaz M. Abdou; Paul M. O'Neill; Eric Amigues; Magdalini Matziari

doi:10.1016/j.drudis.2018.11.016

Phosphinic acids: current status and potential for drug discovery

Moaz M. Abdou
, Paul M. O'Neill
, Eric Amigues
, Magdalini Matziari^*

^*Corresponding author for this work

Department of Chemistry and Materials Science

Egyptian Petroleum Research Institute
Xi'an Jiaotong-Liverpool University
University of Liverpool

Research output: Contribution to journal › Review article › peer-review

49 Citations (Scopus)

Abstract

Phosphinic acid derivatives exhibit diverse biological activities and a high degree of structural diversity, rendering them a versatile tool in the development of new medicinal agents. Pronounced recent progress, coupled with previous research findings, highlights the impact of this moiety in medicinal chemistry. Here, we highlight the most important breakthroughs made with phosphinates with a range of pharmacological activities against many diseases, including anti-inflammatory, anti-Alzheimer, antiparasitic, antihepatitis, antiproliferative, anti-influenza, anti-HIV, antimalarial, and antimicrobial agents.

Original language	English
Pages (from-to)	916-929
Number of pages	14
Journal	Drug Discovery Today
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.drudis.2018.11.016
Publication status	Published - Mar 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.drudis.2018.11.016

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abstract = "Phosphinic acid derivatives exhibit diverse biological activities and a high degree of structural diversity, rendering them a versatile tool in the development of new medicinal agents. Pronounced recent progress, coupled with previous research findings, highlights the impact of this moiety in medicinal chemistry. Here, we highlight the most important breakthroughs made with phosphinates with a range of pharmacological activities against many diseases, including anti-inflammatory, anti-Alzheimer, antiparasitic, antihepatitis, antiproliferative, anti-influenza, anti-HIV, antimalarial, and antimicrobial agents.",

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AU - O'Neill, Paul M.

AU - Amigues, Eric

AU - Matziari, Magdalini

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AB - Phosphinic acid derivatives exhibit diverse biological activities and a high degree of structural diversity, rendering them a versatile tool in the development of new medicinal agents. Pronounced recent progress, coupled with previous research findings, highlights the impact of this moiety in medicinal chemistry. Here, we highlight the most important breakthroughs made with phosphinates with a range of pharmacological activities against many diseases, including anti-inflammatory, anti-Alzheimer, antiparasitic, antihepatitis, antiproliferative, anti-influenza, anti-HIV, antimalarial, and antimicrobial agents.

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DO - 10.1016/j.drudis.2018.11.016

M3 - Review article

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JO - Drug Discovery Today

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ER -

Phosphinic acids: current status and potential for drug discovery

Abstract

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