Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

Adam Stewart; Nadine Wu; Jonathan Cachat; Peter Hart; Siddharth Gaikwad; Keith Wong; Eli Utterback; Thomas Gilder; Evan Kyzar; Alan Newman; Dillon Carlos; Katie Chang; Molly Hook; Catherine Rhymes; Michael Caffery; Mitchell Greenberg; James Zadina; Allan V. Kalueff

doi:10.1016/j.pnpbp.2010.11.035

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

Adam Stewart
, Nadine Wu
, Jonathan Cachat
, Peter Hart
, Siddharth Gaikwad
, Keith Wong
, Eli Utterback
, Thomas Gilder
, Evan Kyzar
, Alan Newman
, Dillon Carlos
, Katie Chang
, Molly Hook
, Catherine Rhymes
, Michael Caffery
, Mitchell Greenberg
, James Zadina
, Allan V. Kalueff^*

^*Corresponding author for this work

Tulane University
Department of Pharmacology and Zebrafish Neuroscience Research Consortium
Neuroscience Program

Research output: Contribution to journal › Article › peer-review

212 Citations (Scopus)

Abstract

Zebrafish (Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research.

Original language	English
Pages (from-to)	1421-1431
Number of pages	11
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	35
Issue number	6
DOIs	https://doi.org/10.1016/j.pnpbp.2010.11.035
Publication status	Published - 1 Aug 2011
Externally published	Yes

Keywords

Anxiety
Anxiogenic drugs
Anxiolytic drugs
Novel tank test
Novelty-based paradigms
Zebrafish

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10.1016/j.pnpbp.2010.11.035

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Stewart, A., Wu, N., Cachat, J., Hart, P., Gaikwad, S., Wong, K., Utterback, E., Gilder, T., Kyzar, E., Newman, A., Carlos, D., Chang, K., Hook, M., Rhymes, C., Caffery, M., Greenberg, M., Zadina, J., & Kalueff, A. V. (2011). Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(6), 1421-1431. https://doi.org/10.1016/j.pnpbp.2010.11.035

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title = "Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models",

abstract = "Zebrafish (Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research.",

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author = "Adam Stewart and Nadine Wu and Jonathan Cachat and Peter Hart and Siddharth Gaikwad and Keith Wong and Eli Utterback and Thomas Gilder and Evan Kyzar and Alan Newman and Dillon Carlos and Katie Chang and Molly Hook and Catherine Rhymes and Michael Caffery and Mitchell Greenberg and James Zadina and Kalueff, \{Allan V.\}",

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Stewart, A, Wu, N, Cachat, J, Hart, P, Gaikwad, S, Wong, K, Utterback, E, Gilder, T, Kyzar, E, Newman, A, Carlos, D, Chang, K, Hook, M, Rhymes, C, Caffery, M, Greenberg, M, Zadina, J & Kalueff, AV 2011, 'Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 35, no. 6, pp. 1421-1431. https://doi.org/10.1016/j.pnpbp.2010.11.035

TY - JOUR

T1 - Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

AU - Stewart, Adam

AU - Wu, Nadine

AU - Cachat, Jonathan

AU - Hart, Peter

AU - Gaikwad, Siddharth

AU - Wong, Keith

AU - Utterback, Eli

AU - Gilder, Thomas

AU - Kyzar, Evan

AU - Newman, Alan

AU - Carlos, Dillon

AU - Chang, Katie

AU - Hook, Molly

AU - Rhymes, Catherine

AU - Caffery, Michael

AU - Greenberg, Mitchell

AU - Zadina, James

AU - Kalueff, Allan V.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Zebrafish (Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research.

AB - Zebrafish (Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research.

KW - Anxiety

KW - Anxiogenic drugs

KW - Anxiolytic drugs

KW - Novel tank test

KW - Novelty-based paradigms

KW - Zebrafish

UR - https://www.scopus.com/pages/publications/79960464812

U2 - 10.1016/j.pnpbp.2010.11.035

DO - 10.1016/j.pnpbp.2010.11.035

M3 - Article

C2 - 21122812

AN - SCOPUS:79960464812

SN - 0278-5846

VL - 35

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JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

IS - 6

ER -

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

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Keywords

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