pH-Dependent Cancer-Directed Photodynamic Therapy by a Water-Soluble Graphitic-Phase Carbon Nitride–Porphyrin Nanoprobe

Chi Fai Chan; Yan Zhou; Hongyu Guo; Junying Zhang; Lijun Jiang; Wei Chen; Kwok Keung Shiu; Wai Kwok Wong; Ka Leung Wong

doi:10.1002/cplu.201600085

pH-Dependent Cancer-Directed Photodynamic Therapy by a Water-Soluble Graphitic-Phase Carbon Nitride–Porphyrin Nanoprobe

Chi Fai Chan
, Yan Zhou
, Hongyu Guo
, Junying Zhang^*
, Lijun Jiang
, Wei Chen
, Kwok Keung Shiu
, Wai Kwok Wong
, Ka Leung Wong

^*Corresponding author for this work

Hong Kong Baptist University
Beihang University
University of Texas at Arlington

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Theranostic photodynamic nanomaterials suffer from poor water solubility and nontargeted toxicity. A water-soluble graphitic-phase carbon nitride-based material (g-C₃N₄) conjugated to a positively charged porphyrin P2 (conjugating concentration: 60 μm mg⁻¹ mL⁻¹) is shown to be a new concept of photodynamic therapeutic agent (g-C₃N₄–P2). The pH-sensitive emission of g-C₃N₄ is the driving force for the generation of ¹O₂ from g-C₃N₄–P2. The amount of ¹O₂/light generated from a photosensitizer porphyrin can be controlled by the pH-sensitive emission of g-C₃N₄ at acidic pH (pH 4–6), especially under acidic conditions mimicking those of tumor tissue, and thus has the potential to be utilized as a cancer-selective PDT agent.

Original language	English
Pages (from-to)	535-540
Number of pages	6
Journal	ChemPlusChem
Volume	81
Issue number	6
DOIs	https://doi.org/10.1002/cplu.201600085
Publication status	Published - 1 Jun 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer
graphitic-phase carbon nitride
nanoparticles
pH-responsive materials
photodynamic therapy

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10.1002/cplu.201600085

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title = "pH-Dependent Cancer-Directed Photodynamic Therapy by a Water-Soluble Graphitic-Phase Carbon Nitride–Porphyrin Nanoprobe",

abstract = "Theranostic photodynamic nanomaterials suffer from poor water solubility and nontargeted toxicity. A water-soluble graphitic-phase carbon nitride-based material (g-C3N4) conjugated to a positively charged porphyrin P2 (conjugating concentration: 60 μm mg−1 mL−1) is shown to be a new concept of photodynamic therapeutic agent (g-C3N4–P2). The pH-sensitive emission of g-C3N4 is the driving force for the generation of 1O2 from g-C3N4–P2. The amount of 1O2/light generated from a photosensitizer porphyrin can be controlled by the pH-sensitive emission of g-C3N4 at acidic pH (pH 4–6), especially under acidic conditions mimicking those of tumor tissue, and thus has the potential to be utilized as a cancer-selective PDT agent.",

keywords = "cancer, graphitic-phase carbon nitride, nanoparticles, pH-responsive materials, photodynamic therapy",

author = "Chan, \{Chi Fai\} and Yan Zhou and Hongyu Guo and Junying Zhang and Lijun Jiang and Wei Chen and Shiu, \{Kwok Keung\} and Wong, \{Wai Kwok\} and Wong, \{Ka Leung\}",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2016",

month = jun,

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doi = "10.1002/cplu.201600085",

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AU - Chan, Chi Fai

AU - Zhou, Yan

AU - Guo, Hongyu

AU - Zhang, Junying

AU - Jiang, Lijun

AU - Chen, Wei

AU - Shiu, Kwok Keung

AU - Wong, Wai Kwok

AU - Wong, Ka Leung

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Theranostic photodynamic nanomaterials suffer from poor water solubility and nontargeted toxicity. A water-soluble graphitic-phase carbon nitride-based material (g-C3N4) conjugated to a positively charged porphyrin P2 (conjugating concentration: 60 μm mg−1 mL−1) is shown to be a new concept of photodynamic therapeutic agent (g-C3N4–P2). The pH-sensitive emission of g-C3N4 is the driving force for the generation of 1O2 from g-C3N4–P2. The amount of 1O2/light generated from a photosensitizer porphyrin can be controlled by the pH-sensitive emission of g-C3N4 at acidic pH (pH 4–6), especially under acidic conditions mimicking those of tumor tissue, and thus has the potential to be utilized as a cancer-selective PDT agent.

AB - Theranostic photodynamic nanomaterials suffer from poor water solubility and nontargeted toxicity. A water-soluble graphitic-phase carbon nitride-based material (g-C3N4) conjugated to a positively charged porphyrin P2 (conjugating concentration: 60 μm mg−1 mL−1) is shown to be a new concept of photodynamic therapeutic agent (g-C3N4–P2). The pH-sensitive emission of g-C3N4 is the driving force for the generation of 1O2 from g-C3N4–P2. The amount of 1O2/light generated from a photosensitizer porphyrin can be controlled by the pH-sensitive emission of g-C3N4 at acidic pH (pH 4–6), especially under acidic conditions mimicking those of tumor tissue, and thus has the potential to be utilized as a cancer-selective PDT agent.

KW - cancer

KW - graphitic-phase carbon nitride

KW - nanoparticles

KW - pH-responsive materials

KW - photodynamic therapy

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DO - 10.1002/cplu.201600085

M3 - Article

AN - SCOPUS:84966473422

SN - 2192-6506

VL - 81

SP - 535

EP - 540

JO - ChemPlusChem

JF - ChemPlusChem

IS - 6

ER -

pH-Dependent Cancer-Directed Photodynamic Therapy by a Water-Soluble Graphitic-Phase Carbon Nitride–Porphyrin Nanoprobe

Abstract

UN SDGs

Keywords

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