No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population

Yan Bi; Xiaoye Huang; Weibo Niu; Shiqing Chen; Xi Wu; Yanfei Cao; Rui Zhang; Fengping Yang; Lu Wang; Weidong Li; Yifeng Xu; Lin He; Tao Yu; Guang He

doi:10.1016/j.psychres.2017.02.051

No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population

Yan Bi
, Xiaoye Huang
, Weibo Niu
, Shiqing Chen
, Xi Wu
, Yanfei Cao
, Rui Zhang
, Fengping Yang
, Lu Wang
, Weidong Li
, Yifeng Xu
, Lin He
, Tao Yu^*
, Guang He

^*Corresponding author for this work

Shanghai Jiao Tong University
Fudan University
CAS - Shanghai Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

This study was intended to ascertain whether SNPs in dopaminergic and serotoninergic pathway genes SLC6A2, SLC6A3 and DRD2 are associated with schizophrenia in Han Chinese people. We conducted a case-control study by genotyping 7 SNPs of the three genes in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls despite one positive haplotype (rs1362621-rs2242446-rs5564). Stratified analysis of gender and gene-gene interaction analysis showed no positive results. In summary, our study denies the major role of these SNPs within the three genes for schizophrenia in Han Chinese.

Original language	English
Pages (from-to)	398-400
Number of pages	3
Journal	Psychiatry Research
Volume	253
DOIs	https://doi.org/10.1016/j.psychres.2017.02.051
Publication status	Published - 1 Jul 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Association
Schizophrenia
SNP

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10.1016/j.psychres.2017.02.051

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title = "No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population",

abstract = "This study was intended to ascertain whether SNPs in dopaminergic and serotoninergic pathway genes SLC6A2, SLC6A3 and DRD2 are associated with schizophrenia in Han Chinese people. We conducted a case-control study by genotyping 7 SNPs of the three genes in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls despite one positive haplotype (rs1362621-rs2242446-rs5564). Stratified analysis of gender and gene-gene interaction analysis showed no positive results. In summary, our study denies the major role of these SNPs within the three genes for schizophrenia in Han Chinese.",

keywords = "Association, Schizophrenia, SNP",

author = "Yan Bi and Xiaoye Huang and Weibo Niu and Shiqing Chen and Xi Wu and Yanfei Cao and Rui Zhang and Fengping Yang and Lu Wang and Weidong Li and Yifeng Xu and Lin He and Tao Yu and Guang He",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ireland Ltd",

year = "2017",

month = jul,

day = "1",

doi = "10.1016/j.psychres.2017.02.051",

language = "English",

volume = "253",

pages = "398--400",

journal = "Psychiatry Research",

issn = "0165-1781",

}

TY - JOUR

T1 - No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population

AU - Bi, Yan

AU - Huang, Xiaoye

AU - Niu, Weibo

AU - Chen, Shiqing

AU - Wu, Xi

AU - Cao, Yanfei

AU - Zhang, Rui

AU - Yang, Fengping

AU - Wang, Lu

AU - Li, Weidong

AU - Xu, Yifeng

AU - He, Lin

AU - Yu, Tao

AU - He, Guang

PY - 2017/7/1

Y1 - 2017/7/1

N2 - This study was intended to ascertain whether SNPs in dopaminergic and serotoninergic pathway genes SLC6A2, SLC6A3 and DRD2 are associated with schizophrenia in Han Chinese people. We conducted a case-control study by genotyping 7 SNPs of the three genes in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls despite one positive haplotype (rs1362621-rs2242446-rs5564). Stratified analysis of gender and gene-gene interaction analysis showed no positive results. In summary, our study denies the major role of these SNPs within the three genes for schizophrenia in Han Chinese.

AB - This study was intended to ascertain whether SNPs in dopaminergic and serotoninergic pathway genes SLC6A2, SLC6A3 and DRD2 are associated with schizophrenia in Han Chinese people. We conducted a case-control study by genotyping 7 SNPs of the three genes in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls despite one positive haplotype (rs1362621-rs2242446-rs5564). Stratified analysis of gender and gene-gene interaction analysis showed no positive results. In summary, our study denies the major role of these SNPs within the three genes for schizophrenia in Han Chinese.

KW - Association

KW - Schizophrenia

KW - SNP

UR - https://www.scopus.com/pages/publications/85018625947

U2 - 10.1016/j.psychres.2017.02.051

DO - 10.1016/j.psychres.2017.02.051

M3 - Article

C2 - 28454051

AN - SCOPUS:85018625947

SN - 0165-1781

VL - 253

SP - 398

EP - 400

JO - Psychiatry Research

JF - Psychiatry Research

ER -

No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population

Abstract

UN SDGs

Keywords

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