Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology

Adam Stewart; Keith Wong; Jonathan Cachat; Marco Elegante; Tom Gilder; Sopan Mohnot; Nadine Wu; Anna Minasyan; Pentti Tuohimaa; Allan V. Kalueff

doi:10.1097/FBP.0b013e32833c850f

Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology

Adam Stewart
, Keith Wong
, Jonathan Cachat
, Marco Elegante
, Tom Gilder
, Sopan Mohnot
, Nadine Wu
, Anna Minasyan
, Pentti Tuohimaa
, Allan V. Kalueff

Research output: Contribution to journal › Review article › peer-review

32 Citations (Scopus)

Abstract

Vitamin D is becoming increasingly recognized as a nontraditional drug target for different brain pathologies. Although widely known for their role in calcium metabolism, vitamin D and its receptor have been linked to several brain disorders, including cognitive decline, epilepsy, affective disorders, and schizophrenia. Here we discuss mounting evidence, and parallel recent clinical and animal behavioral, genetic and pharmacological data to emphasize the emerging role of the neurosteroid vitamin D system in brain function.

Original language	English
Pages (from-to)	420-426
Number of pages	7
Journal	Behavioural Pharmacology
Volume	21
Issue number	5-6
DOIs	https://doi.org/10.1097/FBP.0b013e32833c850f
Publication status	Published - Sept 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

genetic polymorphisms
hypovitaminosis D
mutant mouse models
neurobehavioral disorders
vitamin D
vitamin D receptor

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10.1097/FBP.0b013e32833c850f

Cite this

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title = "Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology",

abstract = "Vitamin D is becoming increasingly recognized as a nontraditional drug target for different brain pathologies. Although widely known for their role in calcium metabolism, vitamin D and its receptor have been linked to several brain disorders, including cognitive decline, epilepsy, affective disorders, and schizophrenia. Here we discuss mounting evidence, and parallel recent clinical and animal behavioral, genetic and pharmacological data to emphasize the emerging role of the neurosteroid vitamin D system in brain function.",

keywords = "genetic polymorphisms, hypovitaminosis D, mutant mouse models, neurobehavioral disorders, vitamin D, vitamin D receptor",

author = "Adam Stewart and Keith Wong and Jonathan Cachat and Marco Elegante and Tom Gilder and Sopan Mohnot and Nadine Wu and Anna Minasyan and Pentti Tuohimaa and Kalueff, \{Allan V.\}",

year = "2010",

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language = "English",

volume = "21",

pages = "420--426",

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T1 - Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology

AU - Stewart, Adam

AU - Wong, Keith

AU - Cachat, Jonathan

AU - Elegante, Marco

AU - Gilder, Tom

AU - Mohnot, Sopan

AU - Wu, Nadine

AU - Minasyan, Anna

AU - Tuohimaa, Pentti

AU - Kalueff, Allan V.

PY - 2010/9

Y1 - 2010/9

N2 - Vitamin D is becoming increasingly recognized as a nontraditional drug target for different brain pathologies. Although widely known for their role in calcium metabolism, vitamin D and its receptor have been linked to several brain disorders, including cognitive decline, epilepsy, affective disorders, and schizophrenia. Here we discuss mounting evidence, and parallel recent clinical and animal behavioral, genetic and pharmacological data to emphasize the emerging role of the neurosteroid vitamin D system in brain function.

AB - Vitamin D is becoming increasingly recognized as a nontraditional drug target for different brain pathologies. Although widely known for their role in calcium metabolism, vitamin D and its receptor have been linked to several brain disorders, including cognitive decline, epilepsy, affective disorders, and schizophrenia. Here we discuss mounting evidence, and parallel recent clinical and animal behavioral, genetic and pharmacological data to emphasize the emerging role of the neurosteroid vitamin D system in brain function.

KW - genetic polymorphisms

KW - hypovitaminosis D

KW - mutant mouse models

KW - neurobehavioral disorders

KW - vitamin D

KW - vitamin D receptor

UR - https://www.scopus.com/pages/publications/77955983257

U2 - 10.1097/FBP.0b013e32833c850f

DO - 10.1097/FBP.0b013e32833c850f

M3 - Review article

C2 - 20571365

AN - SCOPUS:77955983257

SN - 0955-8810

VL - 21

SP - 420

EP - 426

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

IS - 5-6

ER -

Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology

Abstract

UN SDGs

Keywords

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