Modeling stress and anxiety in zebrafish

Jonathan M. Cachat; Peter R. Canavello; Marco F. Elegante; Brett K. Bartels; Salem I. Elkhayat; Peter C. Hart; Anna K. Tien; David H. Tien; Esther Beeson; Sopan Mohnot; Autumn L. Laffoon; Adam M. Stewart; Siddharth Gaikwad; Keith Wong; Whitlee Haymore; Allan V. Kalueff

doi:10.1007/978-1-60761-922-2_3

Modeling stress and anxiety in zebrafish

Jonathan M. Cachat
, Peter R. Canavello
, Marco F. Elegante
, Brett K. Bartels
, Salem I. Elkhayat
, Peter C. Hart
, Anna K. Tien
, David H. Tien
, Esther Beeson
, Sopan Mohnot
, Autumn L. Laffoon
, Adam M. Stewart
, Siddharth Gaikwad
, Keith Wong
, Whitlee Haymore
, Allan V. Kalueff

Tulane University

Research output: Chapter in Book or Report/Conference proceeding › Chapter › peer-review

61 Citations (Scopus)

Abstract

While zebrafish (Danio rerio) are widely utilized as a model species for neuroscience research, they also possess several qualities that make them particularly useful for studying stress and anxiety-related behaviors. Zebrafish neuroendocrine responses are robust, and correlate strongly with behavioral endpoints. These fish are also highly sensitive to various environmental challenges, including novelty stress, exposure to predators, alarm pheromone, anxiogenic drugs, and drug withdrawal. In addition, varying levels of baseline anxiety can be observed in different strains of zebrafish. Collectively, this supports the validity and efficacy of the adult zebrafish model for studying both acute and chronic anxiety.

Original language	English
Title of host publication	Zebrafish Models in Neurobehavioral Research
Editors	Allan Kalueff, Jonathan Cachat
Pages	73-88
Number of pages	16
DOIs	https://doi.org/10.1007/978-1-60761-922-2_3
Publication status	Published - 2011
Externally published	Yes

Publication series

Name	Neuromethods
Volume	52
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

affective behavior
anxiety
behavioral phenotyping
drug withdrawal
endocrine response
endocrine signaling
fear
genetic differences
Novel environment
novel tank test
predator stress
stress
video-aided analysis

Access to Document

10.1007/978-1-60761-922-2_3

Cite this

Cachat, J. M., Canavello, P. R., Elegante, M. F., Bartels, B. K., Elkhayat, S. I., Hart, P. C., Tien, A. K., Tien, D. H., Beeson, E., Mohnot, S., Laffoon, A. L., Stewart, A. M., Gaikwad, S., Wong, K., Haymore, W., & Kalueff, A. V. (2011). Modeling stress and anxiety in zebrafish. In A. Kalueff, & J. Cachat (Eds.), Zebrafish Models in Neurobehavioral Research (pp. 73-88). (Neuromethods; Vol. 52). https://doi.org/10.1007/978-1-60761-922-2_3

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title = "Modeling stress and anxiety in zebrafish",

abstract = "While zebrafish (Danio rerio) are widely utilized as a model species for neuroscience research, they also possess several qualities that make them particularly useful for studying stress and anxiety-related behaviors. Zebrafish neuroendocrine responses are robust, and correlate strongly with behavioral endpoints. These fish are also highly sensitive to various environmental challenges, including novelty stress, exposure to predators, alarm pheromone, anxiogenic drugs, and drug withdrawal. In addition, varying levels of baseline anxiety can be observed in different strains of zebrafish. Collectively, this supports the validity and efficacy of the adult zebrafish model for studying both acute and chronic anxiety.",

keywords = "affective behavior, anxiety, behavioral phenotyping, drug withdrawal, endocrine response, endocrine signaling, fear, genetic differences, Novel environment, novel tank test, predator stress, stress, video-aided analysis",

author = "Cachat, \{Jonathan M.\} and Canavello, \{Peter R.\} and Elegante, \{Marco F.\} and Bartels, \{Brett K.\} and Elkhayat, \{Salem I.\} and Hart, \{Peter C.\} and Tien, \{Anna K.\} and Tien, \{David H.\} and Esther Beeson and Sopan Mohnot and Laffoon, \{Autumn L.\} and Stewart, \{Adam M.\} and Siddharth Gaikwad and Keith Wong and Whitlee Haymore and Kalueff, \{Allan V.\}",

year = "2011",

doi = "10.1007/978-1-60761-922-2\_3",

language = "English",

isbn = "9781607619215",

series = "Neuromethods",

pages = "73--88",

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Cachat, JM, Canavello, PR, Elegante, MF, Bartels, BK, Elkhayat, SI, Hart, PC, Tien, AK, Tien, DH, Beeson, E, Mohnot, S, Laffoon, AL, Stewart, AM, Gaikwad, S, Wong, K, Haymore, W & Kalueff, AV 2011, Modeling stress and anxiety in zebrafish. in A Kalueff & J Cachat (eds), Zebrafish Models in Neurobehavioral Research. Neuromethods, vol. 52, pp. 73-88. https://doi.org/10.1007/978-1-60761-922-2_3

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T1 - Modeling stress and anxiety in zebrafish

AU - Cachat, Jonathan M.

AU - Canavello, Peter R.

AU - Elegante, Marco F.

AU - Bartels, Brett K.

AU - Elkhayat, Salem I.

AU - Hart, Peter C.

AU - Tien, Anna K.

AU - Tien, David H.

AU - Beeson, Esther

AU - Mohnot, Sopan

AU - Laffoon, Autumn L.

AU - Stewart, Adam M.

AU - Gaikwad, Siddharth

AU - Wong, Keith

AU - Haymore, Whitlee

AU - Kalueff, Allan V.

PY - 2011

Y1 - 2011

N2 - While zebrafish (Danio rerio) are widely utilized as a model species for neuroscience research, they also possess several qualities that make them particularly useful for studying stress and anxiety-related behaviors. Zebrafish neuroendocrine responses are robust, and correlate strongly with behavioral endpoints. These fish are also highly sensitive to various environmental challenges, including novelty stress, exposure to predators, alarm pheromone, anxiogenic drugs, and drug withdrawal. In addition, varying levels of baseline anxiety can be observed in different strains of zebrafish. Collectively, this supports the validity and efficacy of the adult zebrafish model for studying both acute and chronic anxiety.

AB - While zebrafish (Danio rerio) are widely utilized as a model species for neuroscience research, they also possess several qualities that make them particularly useful for studying stress and anxiety-related behaviors. Zebrafish neuroendocrine responses are robust, and correlate strongly with behavioral endpoints. These fish are also highly sensitive to various environmental challenges, including novelty stress, exposure to predators, alarm pheromone, anxiogenic drugs, and drug withdrawal. In addition, varying levels of baseline anxiety can be observed in different strains of zebrafish. Collectively, this supports the validity and efficacy of the adult zebrafish model for studying both acute and chronic anxiety.

KW - affective behavior

KW - anxiety

KW - behavioral phenotyping

KW - drug withdrawal

KW - endocrine response

KW - endocrine signaling

KW - fear

KW - genetic differences

KW - Novel environment

KW - novel tank test

KW - predator stress

KW - stress

KW - video-aided analysis

UR - https://www.scopus.com/pages/publications/78649502864

U2 - 10.1007/978-1-60761-922-2_3

DO - 10.1007/978-1-60761-922-2_3

M3 - Chapter

AN - SCOPUS:78649502864

SN - 9781607619215

T3 - Neuromethods

SP - 73

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BT - Zebrafish Models in Neurobehavioral Research

A2 - Kalueff, Allan

A2 - Cachat, Jonathan

ER -

Modeling stress and anxiety in zebrafish

Abstract

Publication series

UN SDGs

Keywords

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