Modeling depression in zebrafish

David S. Galstyan; Tatyana O. Kolesnikova; Yurii M. Kositsyn; Konstantin N. Zabegalov; Mariya A. Gubaidullina; Gleb O. Maslov; Konstantin A. Demin; Sergey L. Khatsko; Allan V. Kalueff

doi:10.17816/RCF202149-156

Modeling depression in zebrafish

David S. Galstyan
, Tatyana O. Kolesnikova
, Yurii M. Kositsyn
, Konstantin N. Zabegalov
, Mariya A. Gubaidullina
, Gleb O. Maslov
, Konstantin A. Demin
, Sergey L. Khatsko
, Allan V. Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Depression is a widespread, severely debilitating mental disorder characterized by low mood, anhedonia, fatigue, decreased attention, suicidality and psychomotor retardation, accompanied by neuroendocrine and molecular disorders. Zebrafish have neuroendocrine and neurotransmitter systems similar to humans, as well as high genetic homology, and are rapidly becoming popular model organisms for modeling depressive-like conditions. Here, we discuss modern behavioral, pharmacological and genetic models of depression in zebrafish, their methodological applications and translational implications.

Original language	English
Pages (from-to)	149-156
Number of pages	8
Journal	Reviews on Clinical Pharmacology and Drug Therapy
Volume	20
Issue number	2
DOIs	https://doi.org/10.17816/RCF202149-156
Publication status	Published - 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

chronic stress
depression
despair
reserpine
zebrafish

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10.17816/RCF202149-156

Cite this

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title = "Modeling depression in zebrafish",

abstract = "Depression is a widespread, severely debilitating mental disorder characterized by low mood, anhedonia, fatigue, decreased attention, suicidality and psychomotor retardation, accompanied by neuroendocrine and molecular disorders. Zebrafish have neuroendocrine and neurotransmitter systems similar to humans, as well as high genetic homology, and are rapidly becoming popular model organisms for modeling depressive-like conditions. Here, we discuss modern behavioral, pharmacological and genetic models of depression in zebrafish, their methodological applications and translational implications.",

keywords = "chronic stress, depression, despair, reserpine, zebrafish",

author = "Galstyan, \{David S.\} and Kolesnikova, \{Tatyana O.\} and Kositsyn, \{Yurii M.\} and Zabegalov, \{Konstantin N.\} and Gubaidullina, \{Mariya A.\} and Maslov, \{Gleb O.\} and Demin, \{Konstantin A.\} and Khatsko, \{Sergey L.\} and Kalueff, \{Allan V.\}",

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year = "2022",

doi = "10.17816/RCF202149-156",

language = "English",

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pages = "149--156",

journal = "Reviews on Clinical Pharmacology and Drug Therapy",

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TY - JOUR

T1 - Modeling depression in zebrafish

AU - Galstyan, David S.

AU - Kolesnikova, Tatyana O.

AU - Kositsyn, Yurii M.

AU - Zabegalov, Konstantin N.

AU - Gubaidullina, Mariya A.

AU - Maslov, Gleb O.

AU - Demin, Konstantin A.

AU - Khatsko, Sergey L.

AU - Kalueff, Allan V.

N1 - Publisher Copyright: © Authors, 2022.

PY - 2022

Y1 - 2022

N2 - Depression is a widespread, severely debilitating mental disorder characterized by low mood, anhedonia, fatigue, decreased attention, suicidality and psychomotor retardation, accompanied by neuroendocrine and molecular disorders. Zebrafish have neuroendocrine and neurotransmitter systems similar to humans, as well as high genetic homology, and are rapidly becoming popular model organisms for modeling depressive-like conditions. Here, we discuss modern behavioral, pharmacological and genetic models of depression in zebrafish, their methodological applications and translational implications.

AB - Depression is a widespread, severely debilitating mental disorder characterized by low mood, anhedonia, fatigue, decreased attention, suicidality and psychomotor retardation, accompanied by neuroendocrine and molecular disorders. Zebrafish have neuroendocrine and neurotransmitter systems similar to humans, as well as high genetic homology, and are rapidly becoming popular model organisms for modeling depressive-like conditions. Here, we discuss modern behavioral, pharmacological and genetic models of depression in zebrafish, their methodological applications and translational implications.

KW - chronic stress

KW - depression

KW - despair

KW - reserpine

KW - zebrafish

UR - https://www.scopus.com/pages/publications/85166761063

U2 - 10.17816/RCF202149-156

DO - 10.17816/RCF202149-156

M3 - Article

AN - SCOPUS:85166761063

SN - 1683-4100

VL - 20

SP - 149

EP - 156

JO - Reviews on Clinical Pharmacology and Drug Therapy

JF - Reviews on Clinical Pharmacology and Drug Therapy

IS - 2

ER -

Modeling depression in zebrafish

Abstract

UN SDGs

Keywords

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