TY - JOUR
T1 - Metal-organic frameworks (MOFs) for phototherapy and synergistic phototherapy of cancer
AU - Tong, Pei-Hong
AU - Yang, Jing-Jie
AU - Zhou, Yu-Fan
AU - Tang, Yi-Fan
AU - Tang, Meng-tian
AU - Zang, Yi
AU - Pan, Yu-Fei
AU - Dong, Li-Wei
AU - Tan, Ye-Xiong
AU - Nam, Ki Taek
AU - Hu, Xi-Le
AU - Huang, He
AU - Li, Jia
AU - Wang, Hong-Yang
AU - James, Tony D.
AU - Yoon, Juyoung
AU - He, Xiao-Peng
PY - 2025/3/1
Y1 - 2025/3/1
N2 - Phototherapy is a form of light-mediated therapy, which includes photodynamic therapy (PDT) photothermal therapy (PTT), and the recently emerging photoimmunotherapy (PIT). PTT, PDT, PIT and their combinations with conventional chemotherapeutics have been used extensively to treat cancer due to their outstanding therapeutic efficacy, are non-invasive, mitigate side effects, and display spatial selectivity for a target organ. In addition to the many anticancer phototherapeutic agents developed, metal-organic frameworks (MOFs) are a new generation of promising light-responsive materials owing to their readily tunable chemical structures through simple coordination chemistry as well as their morphological diversity. When properly designed, MOFs can also serve as photodynamic and/or photothermal agents themselves whilst being a carrier to deliver chemo- and macromolecular therapeutic agents owing to their highly tunable porosity. This review highlights recent research progresses made in the development of MOFs-based materials for phototherapy and synergistic phototherapy, as well as discussing any remaining challenges.
AB - Phototherapy is a form of light-mediated therapy, which includes photodynamic therapy (PDT) photothermal therapy (PTT), and the recently emerging photoimmunotherapy (PIT). PTT, PDT, PIT and their combinations with conventional chemotherapeutics have been used extensively to treat cancer due to their outstanding therapeutic efficacy, are non-invasive, mitigate side effects, and display spatial selectivity for a target organ. In addition to the many anticancer phototherapeutic agents developed, metal-organic frameworks (MOFs) are a new generation of promising light-responsive materials owing to their readily tunable chemical structures through simple coordination chemistry as well as their morphological diversity. When properly designed, MOFs can also serve as photodynamic and/or photothermal agents themselves whilst being a carrier to deliver chemo- and macromolecular therapeutic agents owing to their highly tunable porosity. This review highlights recent research progresses made in the development of MOFs-based materials for phototherapy and synergistic phototherapy, as well as discussing any remaining challenges.
KW - Cancer
KW - Metal-organic frameworks (MOFs)
KW - Photodynamic therapy
KW - Phototherapy
KW - Photothermal therapy
KW - Synergistic therapy
U2 - 10.1016/j.ccr.2024.216381
DO - 10.1016/j.ccr.2024.216381
M3 - Article
SN - 0010-8545
VL - 526
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
IS - 216381
M1 - 216381
ER -
