Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model

Myeongsu Seong; Nosoung Myoung; Sang Youp Yim; Jae G. Kim

doi:10.1117/12.2079279

Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model

Myeongsu Seong
, Nosoung Myoung
, Sang Youp Yim
, Jae G. Kim^*

^*Corresponding author for this work

Gwangju Institute of Science and Technology

Research output: Chapter in Book or Report/Conference proceeding › Conference Proceeding › peer-review

Abstract

Because mammography, the gold standard of breast cancer screening and monitoring treatment efficacy, has limitations, there is a necessity to have a new method for breast cancer patients. Raman spectroscopy is considered as one of the best alternative approaches due to its ability of visualizing (bio)chemical information of a matter. In this study, we hypothesized that the change of biochemical composition occurs earlier than morphological change in breast cancer during chemotherapy, and attempted to prove it by employing fiber-optic Raman spectroscopy for longitudinal Raman measurement in small animal breast cancer model. To confirm the hypothesis, we measured Raman spectra of a tumor breast and the contralateral breast during chemotherapy for 4 fisher 344 female rats longitudinally. Principal component analysis and Raman spectral differences between breast tumor and contralateral normal breast did not show a clear difference between them which may have been caused by interference from skin. Thus, spatially-offset Raman spectroscopy will be employed in order to acquire the Raman signal directly from tumor while suppressing Raman signal from skin for the future study.

Original language	English
Title of host publication	Photonic Therapeutics and Diagnostics XI
Editors	Hyun Wook Kang, Justus F. Ilgner, Melissa C. Skala, Laura Marcu, Haishan Zeng, Mark W. Dewhirst, Kenton W. Gregory, Andreas Mandelis, Bernard Choi, Brian Jet-Fei Wong, Claus-Peter Richter, Guillermo J. Tearney, Alfred Nuttal, Nikiforos Kollias
Publisher	SPIE
ISBN (Electronic)	9781628413939
DOIs	https://doi.org/10.1117/12.2079279
Publication status	Published - 2015
Externally published	Yes
Event	Photonic Therapeutics and Diagnostics XI - San Francisco, United States Duration: 7 Feb 2015 → 8 Feb 2015

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9303
ISSN (Print)	1605-7422

Conference

Conference	Photonic Therapeutics and Diagnostics XI
Country/Territory	United States
City	San Francisco
Period	7/02/15 → 8/02/15

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Chemotherapy
Cyclophosphamide (CTX)
Longitudinal study
Principal component analysis (PCA)
Raman spectroscopy (RS)

Access to Document

10.1117/12.2079279

Cite this

Seong, M., Myoung, N., Yim, S. Y., & Kim, J. G. (2015). Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model. In H. W. Kang, J. F. Ilgner, M. C. Skala, L. Marcu, H. Zeng, M. W. Dewhirst, K. W. Gregory, A. Mandelis, B. Choi, B. J.-F. Wong, C.-P. Richter, G. J. Tearney, A. Nuttal, & N. Kollias (Eds.), Photonic Therapeutics and Diagnostics XI Article 93032U (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9303). SPIE. https://doi.org/10.1117/12.2079279

Seong, Myeongsu ; Myoung, Nosoung ; Yim, Sang Youp et al. / Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model. Photonic Therapeutics and Diagnostics XI. editor / Hyun Wook Kang ; Justus F. Ilgner ; Melissa C. Skala ; Laura Marcu ; Haishan Zeng ; Mark W. Dewhirst ; Kenton W. Gregory ; Andreas Mandelis ; Bernard Choi ; Brian Jet-Fei Wong ; Claus-Peter Richter ; Guillermo J. Tearney ; Alfred Nuttal ; Nikiforos Kollias. SPIE, 2015. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

@inproceedings{0762917c70b847f6a87b3707f2bae9b6,

title = "Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model",

abstract = "Because mammography, the gold standard of breast cancer screening and monitoring treatment efficacy, has limitations, there is a necessity to have a new method for breast cancer patients. Raman spectroscopy is considered as one of the best alternative approaches due to its ability of visualizing (bio)chemical information of a matter. In this study, we hypothesized that the change of biochemical composition occurs earlier than morphological change in breast cancer during chemotherapy, and attempted to prove it by employing fiber-optic Raman spectroscopy for longitudinal Raman measurement in small animal breast cancer model. To confirm the hypothesis, we measured Raman spectra of a tumor breast and the contralateral breast during chemotherapy for 4 fisher 344 female rats longitudinally. Principal component analysis and Raman spectral differences between breast tumor and contralateral normal breast did not show a clear difference between them which may have been caused by interference from skin. Thus, spatially-offset Raman spectroscopy will be employed in order to acquire the Raman signal directly from tumor while suppressing Raman signal from skin for the future study.",

keywords = "Breast cancer, Chemotherapy, Cyclophosphamide (CTX), Longitudinal study, Principal component analysis (PCA), Raman spectroscopy (RS)",

author = "Myeongsu Seong and Nosoung Myoung and Yim, \{Sang Youp\} and Kim, \{Jae G.\}",

year = "2015",

doi = "10.1117/12.2079279",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Kang, \{Hyun Wook\} and Ilgner, \{Justus F.\} and Skala, \{Melissa C.\} and Laura Marcu and Haishan Zeng and Dewhirst, \{Mark W.\} and Gregory, \{Kenton W.\} and Andreas Mandelis and Bernard Choi and Wong, \{Brian Jet-Fei\} and Claus-Peter Richter and Tearney, \{Guillermo J.\} and Alfred Nuttal and Nikiforos Kollias",

booktitle = "Photonic Therapeutics and Diagnostics XI",

note = "Photonic Therapeutics and Diagnostics XI ; Conference date: 07-02-2015 Through 08-02-2015",

}

Seong, M, Myoung, N, Yim, SY & Kim, JG 2015, Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model. in HW Kang, JF Ilgner, MC Skala, L Marcu, H Zeng, MW Dewhirst, KW Gregory, A Mandelis, B Choi, BJ-F Wong, C-P Richter, GJ Tearney, A Nuttal & N Kollias (eds), Photonic Therapeutics and Diagnostics XI., 93032U, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9303, SPIE, Photonic Therapeutics and Diagnostics XI, San Francisco, United States, 7/02/15. https://doi.org/10.1117/12.2079279

Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model. / Seong, Myeongsu; Myoung, Nosoung; Yim, Sang Youp et al.
Photonic Therapeutics and Diagnostics XI. ed. / Hyun Wook Kang; Justus F. Ilgner; Melissa C. Skala; Laura Marcu; Haishan Zeng; Mark W. Dewhirst; Kenton W. Gregory; Andreas Mandelis; Bernard Choi; Brian Jet-Fei Wong; Claus-Peter Richter; Guillermo J. Tearney; Alfred Nuttal; Nikiforos Kollias. SPIE, 2015. 93032U (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9303).

Research output: Chapter in Book or Report/Conference proceeding › Conference Proceeding › peer-review

TY - GEN

T1 - Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model

AU - Seong, Myeongsu

AU - Myoung, Nosoung

AU - Yim, Sang Youp

AU - Kim, Jae G.

PY - 2015

Y1 - 2015

N2 - Because mammography, the gold standard of breast cancer screening and monitoring treatment efficacy, has limitations, there is a necessity to have a new method for breast cancer patients. Raman spectroscopy is considered as one of the best alternative approaches due to its ability of visualizing (bio)chemical information of a matter. In this study, we hypothesized that the change of biochemical composition occurs earlier than morphological change in breast cancer during chemotherapy, and attempted to prove it by employing fiber-optic Raman spectroscopy for longitudinal Raman measurement in small animal breast cancer model. To confirm the hypothesis, we measured Raman spectra of a tumor breast and the contralateral breast during chemotherapy for 4 fisher 344 female rats longitudinally. Principal component analysis and Raman spectral differences between breast tumor and contralateral normal breast did not show a clear difference between them which may have been caused by interference from skin. Thus, spatially-offset Raman spectroscopy will be employed in order to acquire the Raman signal directly from tumor while suppressing Raman signal from skin for the future study.

AB - Because mammography, the gold standard of breast cancer screening and monitoring treatment efficacy, has limitations, there is a necessity to have a new method for breast cancer patients. Raman spectroscopy is considered as one of the best alternative approaches due to its ability of visualizing (bio)chemical information of a matter. In this study, we hypothesized that the change of biochemical composition occurs earlier than morphological change in breast cancer during chemotherapy, and attempted to prove it by employing fiber-optic Raman spectroscopy for longitudinal Raman measurement in small animal breast cancer model. To confirm the hypothesis, we measured Raman spectra of a tumor breast and the contralateral breast during chemotherapy for 4 fisher 344 female rats longitudinally. Principal component analysis and Raman spectral differences between breast tumor and contralateral normal breast did not show a clear difference between them which may have been caused by interference from skin. Thus, spatially-offset Raman spectroscopy will be employed in order to acquire the Raman signal directly from tumor while suppressing Raman signal from skin for the future study.

KW - Breast cancer

KW - Chemotherapy

KW - Cyclophosphamide (CTX)

KW - Longitudinal study

KW - Principal component analysis (PCA)

KW - Raman spectroscopy (RS)

UR - https://www.scopus.com/pages/publications/84926628403

U2 - 10.1117/12.2079279

DO - 10.1117/12.2079279

M3 - Conference Proceeding

AN - SCOPUS:84926628403

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photonic Therapeutics and Diagnostics XI

A2 - Kang, Hyun Wook

A2 - Ilgner, Justus F.

A2 - Skala, Melissa C.

A2 - Marcu, Laura

A2 - Zeng, Haishan

A2 - Dewhirst, Mark W.

A2 - Gregory, Kenton W.

A2 - Mandelis, Andreas

A2 - Choi, Bernard

A2 - Wong, Brian Jet-Fei

A2 - Richter, Claus-Peter

A2 - Tearney, Guillermo J.

A2 - Nuttal, Alfred

A2 - Kollias, Nikiforos

PB - SPIE

T2 - Photonic Therapeutics and Diagnostics XI

Y2 - 7 February 2015 through 8 February 2015

ER -

Seong M, Myoung N, Yim SY, Kim JG. Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model. In Kang HW, Ilgner JF, Skala MC, Marcu L, Zeng H, Dewhirst MW, Gregory KW, Mandelis A, Choi B, Wong BJF, Richter CP, Tearney GJ, Nuttal A, Kollias N, editors, Photonic Therapeutics and Diagnostics XI. SPIE. 2015. 93032U. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2079279

Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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