Late-life depression and alzheimer disease: A potential synergy of the underlying mechanisms

Jerzy Leszek; Elżbieta Trypka; Euphrosyni Koutsouraki; Dimitrios Michmizos; Nagendra Sastry Yarla; Vadim V. Tarasov; Ghulam Md Ashraf; Gjumrakch Aliev

doi:10.2174/0929867323666160902152829

Late-life depression and alzheimer disease: A potential synergy of the underlying mechanisms

Jerzy Leszek
, Elżbieta Trypka
, Euphrosyni Koutsouraki
, Dimitrios Michmizos
, Nagendra Sastry Yarla
, Vadim V. Tarasov
, Ghulam Md Ashraf
, Gjumrakch Aliev^*

^*Corresponding author for this work

Wrocław Medical University
Aristotle University of Thessaloniki
Gandhi Institute of Technology and Management
Sechenov First Moscow State Medical University
King Fahd Medical Research Center (GMA)
King Abdulaziz University
GALLY International Biomedical Research Consulting LLC
University of Atlanta
Russian Academy of Sciences

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

Abstract

A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.

Original language	English
Pages (from-to)	5389-5394
Number of pages	6
Journal	Current Medicinal Chemistry
Volume	25
Issue number	39
DOIs	https://doi.org/10.2174/0929867323666160902152829
Publication status	Published - 2018
Externally published	Yes

Keywords

Aging
Alzheimer disease
Bdnf
Dementia
Depression

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10.2174/0929867323666160902152829

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title = "Late-life depression and alzheimer disease: A potential synergy of the underlying mechanisms",

abstract = "A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.",

keywords = "Aging, Alzheimer disease, Bdnf, Dementia, Depression",

author = "Jerzy Leszek and El{\.z}bieta Trypka and Euphrosyni Koutsouraki and Dimitrios Michmizos and Yarla, \{Nagendra Sastry\} and Tarasov, \{Vadim V.\} and Ashraf, \{Ghulam Md\} and Gjumrakch Aliev",

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language = "English",

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T1 - Late-life depression and alzheimer disease

T2 - A potential synergy of the underlying mechanisms

AU - Leszek, Jerzy

AU - Trypka, Elżbieta

AU - Koutsouraki, Euphrosyni

AU - Michmizos, Dimitrios

AU - Yarla, Nagendra Sastry

AU - Tarasov, Vadim V.

AU - Ashraf, Ghulam Md

AU - Aliev, Gjumrakch

PY - 2018

Y1 - 2018

N2 - A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.

AB - A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.

KW - Aging

KW - Alzheimer disease

KW - Bdnf

KW - Dementia

KW - Depression

UR - https://www.scopus.com/pages/publications/85059512747

U2 - 10.2174/0929867323666160902152829

DO - 10.2174/0929867323666160902152829

M3 - Review article

C2 - 27593962

AN - SCOPUS:85059512747

SN - 0929-8673

VL - 25

SP - 5389

EP - 5394

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 39

ER -

Late-life depression and alzheimer disease: A potential synergy of the underlying mechanisms

Abstract

Keywords

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