Iron-catalyzed cross-coupling of secondary alkyl chloride and the alkynes grignard reagent

Wan Jia; Lizhi Zhao; Hengxu Wei; Lindong Zhu; Lei Fu; Weichun Chen

doi:10.6023/cjoc201510031

Iron-catalyzed cross-coupling of secondary alkyl chloride and the alkynes grignard reagent

Wan Jia
, Lizhi Zhao
, Hengxu Wei
, Lindong Zhu
, Lei Fu
, Weichun Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A green, practical and efficient iron-catalyzed, base free cross-coupling reaction of non-activated secondary alkyl halides with the alkynes Grignard reagent has been developed to afford a variety of alkyl alkynes in high yields, using iron(III) chlorides as catalyst. This approach is quick and easy to operate. It exhibits promising in industry since utilizing the low-cost iron as a catalyst instead of expensive palladium or nickel.

Original language	English
Pages (from-to)	1060-1064
Number of pages	5
Journal	Chinese Journal of Organic Chemistry
Volume	36
Issue number	5
DOIs	https://doi.org/10.6023/cjoc201510031
Publication status	Published - 1 May 2016
Externally published	Yes

Keywords

Alkynes Grignard reagents
Cross-coupling reactions
Green chemistry
Iron-catalyzed
Secondary alkyl choloride

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10.6023/cjoc201510031

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title = "Iron-catalyzed cross-coupling of secondary alkyl chloride and the alkynes grignard reagent",

abstract = "A green, practical and efficient iron-catalyzed, base free cross-coupling reaction of non-activated secondary alkyl halides with the alkynes Grignard reagent has been developed to afford a variety of alkyl alkynes in high yields, using iron(III) chlorides as catalyst. This approach is quick and easy to operate. It exhibits promising in industry since utilizing the low-cost iron as a catalyst instead of expensive palladium or nickel.",

keywords = "Alkynes Grignard reagents, Cross-coupling reactions, Green chemistry, Iron-catalyzed, Secondary alkyl choloride",

author = "Wan Jia and Lizhi Zhao and Hengxu Wei and Lindong Zhu and Lei Fu and Weichun Chen",

note = "Publisher Copyright: {\textcopyright} 2016 Chinese Chemical Society \& SIOC, CAS.",

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doi = "10.6023/cjoc201510031",

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T1 - Iron-catalyzed cross-coupling of secondary alkyl chloride and the alkynes grignard reagent

AU - Jia, Wan

AU - Zhao, Lizhi

AU - Wei, Hengxu

AU - Zhu, Lindong

AU - Fu, Lei

AU - Chen, Weichun

PY - 2016/5/1

Y1 - 2016/5/1

N2 - A green, practical and efficient iron-catalyzed, base free cross-coupling reaction of non-activated secondary alkyl halides with the alkynes Grignard reagent has been developed to afford a variety of alkyl alkynes in high yields, using iron(III) chlorides as catalyst. This approach is quick and easy to operate. It exhibits promising in industry since utilizing the low-cost iron as a catalyst instead of expensive palladium or nickel.

AB - A green, practical and efficient iron-catalyzed, base free cross-coupling reaction of non-activated secondary alkyl halides with the alkynes Grignard reagent has been developed to afford a variety of alkyl alkynes in high yields, using iron(III) chlorides as catalyst. This approach is quick and easy to operate. It exhibits promising in industry since utilizing the low-cost iron as a catalyst instead of expensive palladium or nickel.

KW - Alkynes Grignard reagents

KW - Cross-coupling reactions

KW - Green chemistry

KW - Iron-catalyzed

KW - Secondary alkyl choloride

UR - https://www.scopus.com/pages/publications/84971278431

U2 - 10.6023/cjoc201510031

DO - 10.6023/cjoc201510031

M3 - Article

AN - SCOPUS:84971278431

SN - 0253-2786

VL - 36

SP - 1060

EP - 1064

JO - Chinese Journal of Organic Chemistry

JF - Chinese Journal of Organic Chemistry

IS - 5

ER -

Iron-catalyzed cross-coupling of secondary alkyl chloride and the alkynes grignard reagent

Abstract

Keywords

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