Integrated analysis of hela cell microRNAs' microarray data and anti-cancer pathway prediction of beta-sitosterol

Xijia Fei; Dachuang Liu; Cuihong Dai; Aiju Hou; Jianzhong Li; Dechang Xu

doi:10.1109/BIBMW.2012.6470247

Integrated analysis of hela cell microRNAs' microarray data and anti-cancer pathway prediction of beta-sitosterol

Xijia Fei
, Dachuang Liu
, Cuihong Dai
, Aiju Hou
, Jianzhong Li
, Dechang Xu^*

^*Corresponding author for this work

Harbin Institute of Technology

Research output: Chapter in Book or Report/Conference proceeding › Conference Proceeding › peer-review

Abstract

It has remarkable efficacy to treat cervical cancer cell using beta-sitosterol. At present, beta-sitosterol has been used in the clinical treatment of cancer and its side effects are remotely lower than the traditional drug such as cisplatin. However, the anticancer mechanism of beta-sitosterol is unknown in cervical cancer. In this study, we mainly use TaqMan MicroRNA Assay to detect the consequence of Hela cell treatment by beta-sitosterol and cisplatin and analyze it from molecular level. We find out the differentially expressed microRNAs and forecast their targets by Targetscan. We also provide direct evidence that STK4/MST1 is a functional target. From the viewpoint of bioinformatics, we speculate the possible pathway of beta-sitosterol to inhibit tumor.

Original language	English
Title of host publication	Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
Pages	824-830
Number of pages	7
DOIs	https://doi.org/10.1109/BIBMW.2012.6470247
Publication status	Published - 2012
Externally published	Yes
Event	2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012 - Philadelphia, PA, United States Duration: 4 Oct 2012 → 7 Oct 2012

Publication series

Name	Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012

Conference

Conference	2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
Country/Territory	United States
City	Philadelphia, PA
Period	4/10/12 → 7/10/12

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

STK4/MST1
beta-sitosterol
hela
microarray

Access to Document

10.1109/BIBMW.2012.6470247

Cite this

Fei, X., Liu, D., Dai, C., Hou, A., Li, J., & Xu, D. (2012). Integrated analysis of hela cell microRNAs' microarray data and anti-cancer pathway prediction of beta-sitosterol. In Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012 (pp. 824-830). Article 6470247 (Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012). https://doi.org/10.1109/BIBMW.2012.6470247

Fei, Xijia ; Liu, Dachuang ; Dai, Cuihong et al. / Integrated analysis of hela cell microRNAs' microarray data and anti-cancer pathway prediction of beta-sitosterol. Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012. 2012. pp. 824-830 (Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012).

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title = "Integrated analysis of hela cell microRNAs' microarray data and anti-cancer pathway prediction of beta-sitosterol",

abstract = "It has remarkable efficacy to treat cervical cancer cell using beta-sitosterol. At present, beta-sitosterol has been used in the clinical treatment of cancer and its side effects are remotely lower than the traditional drug such as cisplatin. However, the anticancer mechanism of beta-sitosterol is unknown in cervical cancer. In this study, we mainly use TaqMan MicroRNA Assay to detect the consequence of Hela cell treatment by beta-sitosterol and cisplatin and analyze it from molecular level. We find out the differentially expressed microRNAs and forecast their targets by Targetscan. We also provide direct evidence that STK4/MST1 is a functional target. From the viewpoint of bioinformatics, we speculate the possible pathway of beta-sitosterol to inhibit tumor.",

keywords = "STK4/MST1, beta-sitosterol, hela, microarray",

author = "Xijia Fei and Dachuang Liu and Cuihong Dai and Aiju Hou and Jianzhong Li and Dechang Xu",

year = "2012",

doi = "10.1109/BIBMW.2012.6470247",

language = "English",

isbn = "9781467327466",

series = "Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012",

pages = "824--830",

booktitle = "Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012",

note = "2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012 ; Conference date: 04-10-2012 Through 07-10-2012",

}

Fei, X, Liu, D, Dai, C, Hou, A, Li, J & Xu, D 2012, Integrated analysis of hela cell microRNAs' microarray data and anti-cancer pathway prediction of beta-sitosterol. in Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012., 6470247, Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012, pp. 824-830, 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012, Philadelphia, PA, United States, 4/10/12. https://doi.org/10.1109/BIBMW.2012.6470247

Integrated analysis of hela cell microRNAs' microarray data and anti-cancer pathway prediction of beta-sitosterol. / Fei, Xijia; Liu, Dachuang; Dai, Cuihong et al.
Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012. 2012. p. 824-830 6470247 (Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012).

Research output: Chapter in Book or Report/Conference proceeding › Conference Proceeding › peer-review

TY - GEN

T1 - Integrated analysis of hela cell microRNAs' microarray data and anti-cancer pathway prediction of beta-sitosterol

AU - Fei, Xijia

AU - Liu, Dachuang

AU - Dai, Cuihong

AU - Hou, Aiju

AU - Li, Jianzhong

AU - Xu, Dechang

PY - 2012

Y1 - 2012

N2 - It has remarkable efficacy to treat cervical cancer cell using beta-sitosterol. At present, beta-sitosterol has been used in the clinical treatment of cancer and its side effects are remotely lower than the traditional drug such as cisplatin. However, the anticancer mechanism of beta-sitosterol is unknown in cervical cancer. In this study, we mainly use TaqMan MicroRNA Assay to detect the consequence of Hela cell treatment by beta-sitosterol and cisplatin and analyze it from molecular level. We find out the differentially expressed microRNAs and forecast their targets by Targetscan. We also provide direct evidence that STK4/MST1 is a functional target. From the viewpoint of bioinformatics, we speculate the possible pathway of beta-sitosterol to inhibit tumor.

AB - It has remarkable efficacy to treat cervical cancer cell using beta-sitosterol. At present, beta-sitosterol has been used in the clinical treatment of cancer and its side effects are remotely lower than the traditional drug such as cisplatin. However, the anticancer mechanism of beta-sitosterol is unknown in cervical cancer. In this study, we mainly use TaqMan MicroRNA Assay to detect the consequence of Hela cell treatment by beta-sitosterol and cisplatin and analyze it from molecular level. We find out the differentially expressed microRNAs and forecast their targets by Targetscan. We also provide direct evidence that STK4/MST1 is a functional target. From the viewpoint of bioinformatics, we speculate the possible pathway of beta-sitosterol to inhibit tumor.

KW - STK4/MST1

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KW - hela

KW - microarray

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T3 - Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012

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BT - Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012

T2 - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012

Y2 - 4 October 2012 through 7 October 2012

ER -

Fei X, Liu D, Dai C, Hou A, Li J, Xu D. Integrated analysis of hela cell microRNAs' microarray data and anti-cancer pathway prediction of beta-sitosterol. In Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012. 2012. p. 824-830. 6470247. (Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012). doi: 10.1109/BIBMW.2012.6470247

Integrated analysis of hela cell microRNAs' microarray data and anti-cancer pathway prediction of beta-sitosterol

Abstract

Publication series

Conference

UN SDGs

Keywords

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