Abstract
Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes, the A. mellifera genome has high A+T and CpG contents, lacks major transposon families, evolves more slowly, and is more similar to vertebrates for circadian rhythm, RNA interference and DNA methylation genes, among others. Furthermore, A. mellifera has fewer genes for innate immunity, detoxification enzymes, cuticle-forming proteins and gustatory receptors, more genes for odorant receptors, and novel genes for nectar and pollen utilization, consistent with its ecology and social organization. Compared to Drosophila, genes in early developmental pathways differ in Apis, whereas similarities exist for functions that differ markedly, such as sex determination, brain function and behaviour. Population genetics suggests a novel African origin for the species A. mellifera and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.
| Original language | English |
|---|---|
| Pages (from-to) | 931-949 |
| Number of pages | 19 |
| Journal | Nature |
| Volume | 443 |
| Issue number | 7114 |
| DOIs | |
| Publication status | Published - 26 Oct 2006 |
| Externally published | Yes |
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In: Nature, Vol. 443, No. 7114, 26.10.2006, p. 931-949.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Insights into social insects from the genome of the honeybee Apis mellifera
AU - Weinstock, George M.
AU - Robinson, Gene E.
AU - Gibbs, Richard A.
AU - Worley, Kim C.
AU - Evans, Jay D.
AU - Maleszka, Ryszard
AU - Robertson, Hugh M.
AU - Weaver, Daniel B.
AU - Beye, Martin
AU - Bork, Peer
AU - Elsik, Christine G.
AU - Hartfelder, Klaus
AU - Hunt, Greg J.
AU - Zdobnov, Evgeny M.
AU - Amdam, Gro V.
AU - Bitondi, Mrcia M.G.
AU - Collins, Anita M.
AU - Cristino, Alexandre S.
AU - Lattorff, H. Michael G.
AU - Lobo, Carlos H.
AU - Moritz, Robin F.A.
AU - Nunes, Francis M.F.
AU - Page, Robert E.
AU - Simões, Zilá L.P.
AU - Wheeler, Diana
AU - Carninci, Piero
AU - Fukuda, Shiro
AU - Hayashizaki, Yoshihide
AU - Kai, Chikatoshi
AU - Kawai, Jun
AU - Sakazume, Naoko
AU - Sasaki, Daisuke
AU - Tagami, Michihira
AU - Albert, Stefan
AU - Baggerman, Geert
AU - Beggs, Kyle T.
AU - Bloch, Guy
AU - Cazzamali, Giuseppe
AU - Cohen, Mira
AU - Drapeau, Mark David
AU - Eisenhardt, Dorothea
AU - Emore, Christine
AU - Ewing, Michael A.
AU - Fahrbach, Susan E.
AU - Forêt, Sylvain
AU - Grimmelikhuijzen, Cornelis J.P.
AU - Hauser, Frank
AU - Hummon, Amanda B.
AU - Huybrechts, Jurgen
AU - Jones, Andrew K.
AU - Kadowaki, Tatsuhiko
AU - Kaplan, Noam
AU - Kucharski, Robert
AU - Leboulle, Grard
AU - Linial, Michal
AU - Littleton, J. Troy
AU - Mercer, Alison R.
AU - Richmond, Timothy A.
AU - Rodriguez-Zas, Sandra L.
AU - Rubin, Elad B.
AU - Sattelle, David B.
AU - Schlipalius, David
AU - Schoofs, Liliane
AU - Shemesh, Yair
AU - Sweedler, Jonathan V.
AU - Velarde, Rodrigo
AU - Verleyen, Peter
AU - Vierstraete, Evy
AU - Williamson, Michael R.
AU - Ament, Seth A.
AU - Brown, Susan J.
AU - Corona, Miguel
AU - Dearden, Peter K.
AU - Dunn, W. Augustine
AU - Elekonich, Michelle M.
AU - Fujiyuki, Tomoko
AU - Gattermeier, Irene
AU - Gempe, Tanja
AU - Hasselmann, Martin
AU - Kage, Eriko
AU - Kamikouchi, Azusa
AU - Kubo, Takeo
AU - Kunieda, Takekazu
AU - Lorenzen, Marcé
AU - Milshina, Natalia V.
AU - Morioka, Mizue
AU - Ohashi, Kazuaki
AU - Overbeek, Ross
AU - Ross, Christian A.
AU - Schioett, Morten
AU - Shippy, Teresa
AU - Takeuchi, Hideaki
AU - Toth, Amy L.
AU - Willis, Judith H.
AU - Wilson, Megan J.
AU - Gordon, Karl H.J.
AU - Letunic, Ivica
AU - Hackett, Kevin
AU - Peterson, Jane
AU - Felsenfeld, Adam
AU - Guyer, Mark
AU - Solignac, Michel
AU - Agarwala, Richa
AU - Cornuet, Jean Marie
AU - Monnerot, Monique
AU - Mougel, Florence
AU - Reese, Justin T.
AU - Vautrin, Dominique
AU - Gillespie, Joseph J.
AU - Cannone, Jamie J.
AU - Gutell, Robin R.
AU - Johnston, J. Spencer
AU - Eisen, Michael B.
AU - Iyer, Venky N.
AU - Iyer, Vivek
AU - Kosarev, Peter
AU - Mackey, Aaron J.
AU - Solovyev, Victor
AU - Souvorov, Alexandre
AU - Aronstein, Katherine A.
AU - Bilikova, Katarina
AU - Chen, Yan Ping
AU - Clark, Andrew G.
AU - Decanini, Laura I.
AU - Gelbart, William M.
AU - Hetru, Charles
AU - Hultmark, Dan
AU - Imler, Jean Luc
AU - Jiang, Haobo
AU - Kanost, Michael
AU - Kimura, Kiyoshi
AU - Lazzaro, Brian P.
AU - Lopez, Dawn L.
AU - Simuth, Jozef
AU - Thompson, Graham J.
AU - Zou, Zhen
AU - De Jong, Pieter
AU - Sodergren, Erica
AU - Csurös, Miklós
AU - Milosavljevic, Aleksandar
AU - Osoegawa, Kazutoyo
AU - Richards, Stephen
AU - Shu, Chung Li
AU - Duret, Laurent
AU - Elhaik, Eran
AU - Graur, Dan
AU - Anzola, Juan M.
AU - Campbell, Kathryn S.
AU - Childs, Kevin L.
AU - Collinge, Derek
AU - Crosby, Madeline A.
AU - Dickens, C. Michael
AU - Grametes, L. Sian
AU - Grozinger, Christina M.
AU - Jones, Peter L.
AU - Jorda, Mireia
AU - Ling, Xu
AU - Matthews, Beverly B.
AU - Miller, Jonathan
AU - Mizzen, Craig
AU - Peinado, Miguel A.
AU - Reid, Jeffrey G.
AU - Russo, Susan M.
AU - Schroeder, Andrew J.
AU - St. Pierre, Susan E.
AU - Wang, Ying
AU - Zhou, Pinglei
AU - Jiang, Huaiyang
AU - Kitts, Paul
AU - Ruef, Barbara
AU - Venkatraman, Anand
AU - Zhang, Lan
AU - Aquino-Perez, Gildardo
AU - Whitfield, Charles W.
AU - Behura, Susanta K.
AU - Berlocher, Stewart H.
AU - Sheppard, Walter S.
AU - Smith, Deborah R.
AU - Suarez, Andrew V.
AU - Tsutsui, Neil D.
AU - Wei, Xuehong
AU - Wheeler, David
AU - Havlak, Paul
AU - Li, Bingshan
AU - Liu, Yue
AU - Jovilet, Angela
AU - Lee, Sandra
AU - Nazareth, Lynne V.
AU - Pu, Ling Ling
AU - Thorn, Rachel
AU - Stolc, Viktor
AU - Newman, Thomas
AU - Samanta, Manoj
AU - Tongprasit, Waraporn A.
AU - Claudianos, Charles
AU - Berenbaum, May R.
AU - Biswas, Sunita
AU - De Graaf, Dirk C.
AU - Feyereisen, Rene
AU - Johnson, Reed M.
AU - Oakeshott, John G.
AU - Ranson, Hilary
AU - Schuler, Mary A.
AU - Muzny, Donna
AU - Chacko, Joseph
AU - Davis, Clay
AU - Dinh, Huyen
AU - Gill, Rachel
AU - Hernandez, Judith
AU - Hines, Sandra
AU - Hume, Jennifer
AU - Jackson, La Ronda
AU - Kovar, Christie
AU - Lewis, Lora
AU - Miner, George
AU - Morgan, Margaret
AU - Nguyen, Ngoc
AU - Okwuonu, Geoffrey
AU - Paul, Heidi
AU - Santibanez, Jireh
AU - Savery, Glenford
AU - Svatek, Amanda
AU - Villasana, Donna
AU - Wright, Rita
N1 - Funding Information: Acknowledgements Work at the BCM-HGSC was supported by grants from the NHGRI and USDA. BAC and fosmid Library construction was supported by a subcontract from a grant awarded to J.S.J., organized by D.B.W. (President, Bee Weaver Apiaries, Inc.). Fgenesh and Fgenesh11 analysis was donated by Softberry. Other support was received from NIH NIAID (H.M.R.), NRI Functional Genomics (G.E.R.) and Illinois Sociogenomics Initiative (G.E.R.), NSF (M.M.E.; B. Schatz, UIUC), Intramural Research Program NIH NLM (R.A.), USDA-NRI, California Beekeepers Assoc., Texas Beekeepers Assoc., T. W. Burleson and Son, Inc., TAMU, NIH NLM (J.G.R.), RSNZ Marsden Fund (P.K.D.), Danish Research Agency, Carlsberg Foundation, Novo Nordisk Foundation, and DFG. The authors thank the production staff at the HGSC.
PY - 2006/10/26
Y1 - 2006/10/26
N2 - Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes, the A. mellifera genome has high A+T and CpG contents, lacks major transposon families, evolves more slowly, and is more similar to vertebrates for circadian rhythm, RNA interference and DNA methylation genes, among others. Furthermore, A. mellifera has fewer genes for innate immunity, detoxification enzymes, cuticle-forming proteins and gustatory receptors, more genes for odorant receptors, and novel genes for nectar and pollen utilization, consistent with its ecology and social organization. Compared to Drosophila, genes in early developmental pathways differ in Apis, whereas similarities exist for functions that differ markedly, such as sex determination, brain function and behaviour. Population genetics suggests a novel African origin for the species A. mellifera and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.
AB - Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes, the A. mellifera genome has high A+T and CpG contents, lacks major transposon families, evolves more slowly, and is more similar to vertebrates for circadian rhythm, RNA interference and DNA methylation genes, among others. Furthermore, A. mellifera has fewer genes for innate immunity, detoxification enzymes, cuticle-forming proteins and gustatory receptors, more genes for odorant receptors, and novel genes for nectar and pollen utilization, consistent with its ecology and social organization. Compared to Drosophila, genes in early developmental pathways differ in Apis, whereas similarities exist for functions that differ markedly, such as sex determination, brain function and behaviour. Population genetics suggests a novel African origin for the species A. mellifera and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.
UR - https://www.scopus.com/pages/publications/33750460281
U2 - 10.1038/nature05260
DO - 10.1038/nature05260
M3 - Article
C2 - 17073008
AN - SCOPUS:33750460281
SN - 0028-0836
VL - 443
SP - 931
EP - 949
JO - Nature
JF - Nature
IS - 7114
ER -