Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and antiinflammatory activity and special mechanism

Lin Wei; Jiuxiang Gao; Shumin Zhang; Sijin Wu; Zeping Xie; Guiying Ling; Yi Qun Kuang; Yongliang Yang; Haining Yu; Yipeng Wang

doi:10.1074/jbc.M115.642645

Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and antiinflammatory activity and special mechanism

Lin Wei
, Jiuxiang Gao
, Shumin Zhang
, Sijin Wu
, Zeping Xie
, Guiying Ling
, Yi Qun Kuang
, Yongliang Yang
, Haining Yu^*
, Yipeng Wang

^*Corresponding author for this work

Soochow University
Dalian University of Technology
Binzhou Medical University
Guizhou Medical University
Henan University

Research output: Contribution to journal › Article › peer-review

135 Citations (Scopus)

Abstract

Background: Cathelicidins are a family of vertebrate antimicrobial peptides that play pivotal roles in host immune defense against microbial invasions. Results: A novel cathelicidin (Hc-CATH) with potent antimicrobial and anti-inflammatory activity and a special mechanism was identified from the sea snake Hydrophis cyanocinctus. Conclusion: Hc-CATH is a potent candidate for the development of peptide antibiotics. Significance: Hc-CATH is the first cathelicidin identified from sea snakes and possesses a special anti-inflammatory mechanism.

Original language	English
Pages (from-to)	16633-16652
Number of pages	20
Journal	Journal of Biological Chemistry
Volume	290
Issue number	27
DOIs	https://doi.org/10.1074/jbc.M115.642645
Publication status	Published - 3 Jul 2015
Externally published	Yes

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@article{f91dbfa78c234c26a1a4cccb17337fb1,

title = "Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and antiinflammatory activity and special mechanism",

abstract = "Background: Cathelicidins are a family of vertebrate antimicrobial peptides that play pivotal roles in host immune defense against microbial invasions. Results: A novel cathelicidin (Hc-CATH) with potent antimicrobial and anti-inflammatory activity and a special mechanism was identified from the sea snake Hydrophis cyanocinctus. Conclusion: Hc-CATH is a potent candidate for the development of peptide antibiotics. Significance: Hc-CATH is the first cathelicidin identified from sea snakes and possesses a special anti-inflammatory mechanism.",

author = "Lin Wei and Jiuxiang Gao and Shumin Zhang and Sijin Wu and Zeping Xie and Guiying Ling and Kuang, \{Yi Qun\} and Yongliang Yang and Haining Yu and Yipeng Wang",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

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doi = "10.1074/jbc.M115.642645",

language = "English",

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journal = "Journal of Biological Chemistry",

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TY - JOUR

T1 - Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and antiinflammatory activity and special mechanism

AU - Wei, Lin

AU - Gao, Jiuxiang

AU - Zhang, Shumin

AU - Wu, Sijin

AU - Xie, Zeping

AU - Ling, Guiying

AU - Kuang, Yi Qun

AU - Yang, Yongliang

AU - Yu, Haining

AU - Wang, Yipeng

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Background: Cathelicidins are a family of vertebrate antimicrobial peptides that play pivotal roles in host immune defense against microbial invasions. Results: A novel cathelicidin (Hc-CATH) with potent antimicrobial and anti-inflammatory activity and a special mechanism was identified from the sea snake Hydrophis cyanocinctus. Conclusion: Hc-CATH is a potent candidate for the development of peptide antibiotics. Significance: Hc-CATH is the first cathelicidin identified from sea snakes and possesses a special anti-inflammatory mechanism.

AB - Background: Cathelicidins are a family of vertebrate antimicrobial peptides that play pivotal roles in host immune defense against microbial invasions. Results: A novel cathelicidin (Hc-CATH) with potent antimicrobial and anti-inflammatory activity and a special mechanism was identified from the sea snake Hydrophis cyanocinctus. Conclusion: Hc-CATH is a potent candidate for the development of peptide antibiotics. Significance: Hc-CATH is the first cathelicidin identified from sea snakes and possesses a special anti-inflammatory mechanism.

UR - https://www.scopus.com/pages/publications/84936816932

U2 - 10.1074/jbc.M115.642645

DO - 10.1074/jbc.M115.642645

M3 - Article

C2 - 26013823

AN - SCOPUS:84936816932

SN - 0021-9258

VL - 290

SP - 16633

EP - 16652

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 27

ER -

Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and antiinflammatory activity and special mechanism

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