Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review

Enakshi Sivasudhan; Neil Blake; Zhiliang Lu; Jia Meng; Rong Rong

doi:10.3390/cells11040741

Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review

Enakshi Sivasudhan
, Neil Blake
, Zhiliang Lu
, Jia Meng
, Rong Rong^*

^*Corresponding author for this work

University of Liverpool

Research output: Contribution to journal › Review article › peer-review

131 Citations (Scopus)

Abstract

With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signalling pathways that drive virus-associated hepatocarcinogenesis. This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC by supporting tumour initiation, progression, invasion and metastasis. Understanding HBx-mediated dimensions of complexity in driving liver malignancies could provide the key to unlocking novel and repurposed combinatorial therapies to combat HCC.

Original language	English
Article number	741
Journal	Cells
Volume	11
Issue number	4
DOIs	https://doi.org/10.3390/cells11040741
Publication status	Published - 21 Feb 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer hallmarks
HBx protein
Hepatitis B virus
Hepatocellular carcinoma
Therapeutics

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10.3390/cells11040741

Cite this

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title = "Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review",

abstract = "With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signalling pathways that drive virus-associated hepatocarcinogenesis. This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC by supporting tumour initiation, progression, invasion and metastasis. Understanding HBx-mediated dimensions of complexity in driving liver malignancies could provide the key to unlocking novel and repurposed combinatorial therapies to combat HCC.",

keywords = "Cancer hallmarks, HBx protein, Hepatitis B virus, Hepatocellular carcinoma, Therapeutics",

author = "Enakshi Sivasudhan and Neil Blake and Zhiliang Lu and Jia Meng and Rong Rong",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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T1 - Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma

T2 - A Comprehensive Review

AU - Sivasudhan, Enakshi

AU - Blake, Neil

AU - Lu, Zhiliang

AU - Meng, Jia

AU - Rong, Rong

PY - 2022/2/21

Y1 - 2022/2/21

N2 - With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signalling pathways that drive virus-associated hepatocarcinogenesis. This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC by supporting tumour initiation, progression, invasion and metastasis. Understanding HBx-mediated dimensions of complexity in driving liver malignancies could provide the key to unlocking novel and repurposed combinatorial therapies to combat HCC.

AB - With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signalling pathways that drive virus-associated hepatocarcinogenesis. This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC by supporting tumour initiation, progression, invasion and metastasis. Understanding HBx-mediated dimensions of complexity in driving liver malignancies could provide the key to unlocking novel and repurposed combinatorial therapies to combat HCC.

KW - Cancer hallmarks

KW - HBx protein

KW - Hepatitis B virus

KW - Hepatocellular carcinoma

KW - Therapeutics

UR - https://www.scopus.com/pages/publications/85124943634

U2 - 10.3390/cells11040741

DO - 10.3390/cells11040741

M3 - Review article

C2 - 35203390

AN - SCOPUS:85124943634

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 4

M1 - 741

ER -

Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review

Abstract

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Keywords

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