Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

Zhiqiang Li; Jianhua Chen; Hao Yu; Lin He; Yifeng Xu; Dai Zhang; Qizhong Yi; Changgui Li; Xingwang Li; Jiawei Shen; Zhijian Song; Weidong Ji; Meng Wang; Juan Zhou; Boyu Chen; Yahui Liu; Jiqiang Wang; Peng Wang; Ping Yang; Qingzhong Wang; Guoyin Feng; Benxiu Liu; Wensheng Sun; Baojie Li; Guang He; Weidong Li; Chunling Wan; Qi Xu; Wenjin Li; Zujia Wen; Ke Liu; Fang Huang; Jue Ji; Stephan Ripke; Weihua Yue; Patrick F. Sullivan; Michael C. O'Donovan; Yongyong Shi

doi:10.1038/ng.3973

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

Zhiqiang Li
, Jianhua Chen
, Hao Yu
, Lin He
, Yifeng Xu
, Dai Zhang
, Qizhong Yi
, Changgui Li
, Xingwang Li
, Jiawei Shen
, Zhijian Song
, Weidong Ji
, Meng Wang
, Juan Zhou
, Boyu Chen
, Yahui Liu
, Jiqiang Wang
, Peng Wang
, Ping Yang
, Qingzhong Wang

Guoyin Feng, Benxiu Liu, Wensheng Sun, Baojie Li, Guang He, Weidong Li, Chunling Wan, Qi Xu, Wenjin Li, Zujia Wen, Ke Liu, Fang Huang, Jue Ji, Stephan Ripke, Weihua Yue, Patrick F. Sullivan, Michael C. O'Donovan, Yongyong Shi^*

^*Corresponding author for this work

Qingdao University
Shanghai Jiao Tong University
Tsinghua University
Peking University
Jining Medical College
Xinjiang Medical University
Changning Mental Health Center
Wuhu Fourth People's Hospital
Longquan Mountain Hospital of Guangxi Province
Chinese Academy of Medical Sciences
Massachusetts General Hospital
Broad Institute
Charité – Universitätsmedizin Berlin
University of North Carolina at Chapel Hill
Karolinska Institutet
Cardiff University

Research output: Contribution to journal › Article › peer-review

370 Citations (Scopus)

Abstract

We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese individuals and performed further transancestry meta-analyses with data from the Psychiatry Genomics Consortium (PGC2). Approximately 95% of the genome-wide significant (GWS) index alleles (or their proxies) from the PGC2 study were overrepresented in Chinese schizophrenia cases, including ∼50% that achieved nominal significance and ∼75% that continued to be GWS in the transancestry analysis. The Chinese-only analysis identified seven GWS loci; three of these also were GWS in the transancestry analyses, which identified 109 GWS loci, thus yielding a total of 113 GWS loci (30 novel) in at least one of these analyses. We observed improvements in the fine-mapping resolution at many susceptibility loci. Our results provide several lines of evidence supporting candidate genes at many loci and highlight some pathways for further research. Together, our findings provide novel insight into the genetic architecture and biological etiology of schizophrenia.

Original language	English
Pages (from-to)	1576-1583
Number of pages	8
Journal	Nature Genetics
Volume	49
Issue number	11
DOIs	https://doi.org/10.1038/ng.3973
Publication status	Published - 1 Nov 2017
Externally published	Yes

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10.1038/ng.3973

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@article{109f74bc1c7d423a96bdd60e3d314f29,

title = "Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia",

abstract = "We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese individuals and performed further transancestry meta-analyses with data from the Psychiatry Genomics Consortium (PGC2). Approximately 95\% of the genome-wide significant (GWS) index alleles (or their proxies) from the PGC2 study were overrepresented in Chinese schizophrenia cases, including ∼50\% that achieved nominal significance and ∼75\% that continued to be GWS in the transancestry analysis. The Chinese-only analysis identified seven GWS loci; three of these also were GWS in the transancestry analyses, which identified 109 GWS loci, thus yielding a total of 113 GWS loci (30 novel) in at least one of these analyses. We observed improvements in the fine-mapping resolution at many susceptibility loci. Our results provide several lines of evidence supporting candidate genes at many loci and highlight some pathways for further research. Together, our findings provide novel insight into the genetic architecture and biological etiology of schizophrenia.",

author = "Zhiqiang Li and Jianhua Chen and Hao Yu and Lin He and Yifeng Xu and Dai Zhang and Qizhong Yi and Changgui Li and Xingwang Li and Jiawei Shen and Zhijian Song and Weidong Ji and Meng Wang and Juan Zhou and Boyu Chen and Yahui Liu and Jiqiang Wang and Peng Wang and Ping Yang and Qingzhong Wang and Guoyin Feng and Benxiu Liu and Wensheng Sun and Baojie Li and Guang He and Weidong Li and Chunling Wan and Qi Xu and Wenjin Li and Zujia Wen and Ke Liu and Fang Huang and Jue Ji and Stephan Ripke and Weihua Yue and Sullivan, \{Patrick F.\} and O'Donovan, \{Michael C.\} and Yongyong Shi",

year = "2017",

month = nov,

day = "1",

doi = "10.1038/ng.3973",

language = "English",

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Li, Z, Chen, J, Yu, H, He, L, Xu, Y, Zhang, D, Yi, Q, Li, C, Li, X, Shen, J, Song, Z, Ji, W, Wang, M, Zhou, J, Chen, B, Liu, Y, Wang, J, Wang, P, Yang, P, Wang, Q, Feng, G, Liu, B, Sun, W, Li, B, He, G, Li, W, Wan, C, Xu, Q, Li, W, Wen, Z, Liu, K, Huang, F, Ji, J, Ripke, S, Yue, W, Sullivan, PF, O'Donovan, MC & Shi, Y 2017, 'Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia', Nature Genetics, vol. 49, no. 11, pp. 1576-1583. https://doi.org/10.1038/ng.3973

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AU - Li, Zhiqiang

AU - Chen, Jianhua

AU - Yu, Hao

AU - He, Lin

AU - Xu, Yifeng

AU - Zhang, Dai

AU - Yi, Qizhong

AU - Li, Changgui

AU - Li, Xingwang

AU - Shen, Jiawei

AU - Song, Zhijian

AU - Ji, Weidong

AU - Wang, Meng

AU - Zhou, Juan

AU - Chen, Boyu

AU - Liu, Yahui

AU - Wang, Jiqiang

AU - Wang, Peng

AU - Yang, Ping

AU - Wang, Qingzhong

AU - Feng, Guoyin

AU - Liu, Benxiu

AU - Sun, Wensheng

AU - Li, Baojie

AU - He, Guang

AU - Li, Weidong

AU - Wan, Chunling

AU - Xu, Qi

AU - Li, Wenjin

AU - Wen, Zujia

AU - Liu, Ke

AU - Huang, Fang

AU - Ji, Jue

AU - Ripke, Stephan

AU - Yue, Weihua

AU - Sullivan, Patrick F.

AU - O'Donovan, Michael C.

AU - Shi, Yongyong

PY - 2017/11/1

Y1 - 2017/11/1

N2 - We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese individuals and performed further transancestry meta-analyses with data from the Psychiatry Genomics Consortium (PGC2). Approximately 95% of the genome-wide significant (GWS) index alleles (or their proxies) from the PGC2 study were overrepresented in Chinese schizophrenia cases, including ∼50% that achieved nominal significance and ∼75% that continued to be GWS in the transancestry analysis. The Chinese-only analysis identified seven GWS loci; three of these also were GWS in the transancestry analyses, which identified 109 GWS loci, thus yielding a total of 113 GWS loci (30 novel) in at least one of these analyses. We observed improvements in the fine-mapping resolution at many susceptibility loci. Our results provide several lines of evidence supporting candidate genes at many loci and highlight some pathways for further research. Together, our findings provide novel insight into the genetic architecture and biological etiology of schizophrenia.

AB - We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese individuals and performed further transancestry meta-analyses with data from the Psychiatry Genomics Consortium (PGC2). Approximately 95% of the genome-wide significant (GWS) index alleles (or their proxies) from the PGC2 study were overrepresented in Chinese schizophrenia cases, including ∼50% that achieved nominal significance and ∼75% that continued to be GWS in the transancestry analysis. The Chinese-only analysis identified seven GWS loci; three of these also were GWS in the transancestry analyses, which identified 109 GWS loci, thus yielding a total of 113 GWS loci (30 novel) in at least one of these analyses. We observed improvements in the fine-mapping resolution at many susceptibility loci. Our results provide several lines of evidence supporting candidate genes at many loci and highlight some pathways for further research. Together, our findings provide novel insight into the genetic architecture and biological etiology of schizophrenia.

UR - https://www.scopus.com/pages/publications/85032452147

U2 - 10.1038/ng.3973

DO - 10.1038/ng.3973

M3 - Article

C2 - 28991256

AN - SCOPUS:85032452147

SN - 1061-4036

VL - 49

SP - 1576

EP - 1583

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

Abstract

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