Genetic animal models of depression

Peter R. Canavello; Rupert J. Egan; Carisa L. Bergner; Peter C. Hart; Jonathan M. Cachat; Allan V. Kalueff

doi:10.1007/978-1-60761-474-6_10

Genetic animal models of depression

Peter R. Canavello
, Rupert J. Egan
, Carisa L. Bergner
, Peter C. Hart
, Jonathan M. Cachat
, Allan V. Kalueff

Research output: Chapter in Book or Report/Conference proceeding › Chapter › peer-review

6 Citations (Scopus)

Abstract

Depression, as part of a larger class of affective disorders, is one of the world's most deleterious and widespread neurobehavioral diseases. However, much remains to be discovered concerning depression, due to the daunting complexity of its pathological mechanisms and etiology. Various animal models have been proposed over the years, some of which have come into widespread use, particularly in the area of pharmacological screening. By combining behavioral and physiological analyses with mutant and transgenic animal models, researchers are able to determine the role of specific genes and proteins in the pathogenesis of depression. Discussing several behavioral and transgenic/mutant rodent models, this chapter briefly summarizes the current progress in this area of psychiatric research.

Original language	English
Title of host publication	Transgenic and Mutant Tools to Model Brain Disorders
Editors	Allan V. Kalueff, Carisa L. Bergner
Pages	191-200
Number of pages	10
DOIs	https://doi.org/10.1007/978-1-60761-474-6_10
Publication status	Published - 2010
Externally published	Yes

Publication series

Name	Neuromethods
Volume	44
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anhedonia
Behavioral despair
Depression
Learned helplessnes

Access to Document

10.1007/978-1-60761-474-6_10

Cite this

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T1 - Genetic animal models of depression

AU - Canavello, Peter R.

AU - Egan, Rupert J.

AU - Bergner, Carisa L.

AU - Hart, Peter C.

AU - Cachat, Jonathan M.

AU - Kalueff, Allan V.

PY - 2010

Y1 - 2010

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AB - Depression, as part of a larger class of affective disorders, is one of the world's most deleterious and widespread neurobehavioral diseases. However, much remains to be discovered concerning depression, due to the daunting complexity of its pathological mechanisms and etiology. Various animal models have been proposed over the years, some of which have come into widespread use, particularly in the area of pharmacological screening. By combining behavioral and physiological analyses with mutant and transgenic animal models, researchers are able to determine the role of specific genes and proteins in the pathogenesis of depression. Discussing several behavioral and transgenic/mutant rodent models, this chapter briefly summarizes the current progress in this area of psychiatric research.

KW - Anhedonia

KW - Behavioral despair

KW - Depression

KW - Learned helplessnes

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BT - Transgenic and Mutant Tools to Model Brain Disorders

A2 - Kalueff, Allan V.

A2 - Bergner, Carisa L.

ER -

Genetic animal models of depression

Abstract

Publication series

UN SDGs

Keywords

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