Facile fabrication of graphene oxide loaded with silver nanoparticles as antifungal materials

Jianghu Cui; Yunhua Yang; Mingtao Zheng; Yingliang Liu; Yong Xiao; Bingfu Lei; Wei Chen

doi:10.1088/2053-1591/1/4/045007

Facile fabrication of graphene oxide loaded with silver nanoparticles as antifungal materials

Jianghu Cui
, Yunhua Yang
, Mingtao Zheng
, Yingliang Liu
, Yong Xiao
, Bingfu Lei
, Wei Chen

Guangdong Institute of Eco-Environment and Soil Science
Guangdong Institute of Microbiology
South China Agricultural University
University of Texas at Arlington

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Graphene oxide loaded silver nanoparticles (GO-Ag) were synthesized using a simple method. Our evidence showed that silver nanoparticles (Ag NPs) were successfully loaded on the surface of graphene oxide sheets. The antifungal property of GO-Ag composites was investigated. The results revealed that the obtained GO-Ag composites exhibit enhanced antifungal property in comparison with that of Ag NPs. The toxicity of GO-Ag and Ag NPs were systematically evaluated. The study of cell viability, lactate dehydrogenase, reactive oxygen species, apoptosis/necrosis and hemolysis revealed that GO-Ag composites have lower cytotoxicity and better blood compatibility than Ag NPs. Therefore, these findings provide nanotoxicological information regarding GO-Ag composites which may be alternative antifungal materials in their application of biomedical fields.

Original language	English
Article number	045007
Journal	Materials Research Express
Volume	1
Issue number	4
DOIs	https://doi.org/10.1088/2053-1591/1/4/045007
Publication status	Published - Dec 2015
Externally published	Yes

Keywords

Antifungal
Apoptosis
Graphene oxide
Hemolysis
Oxidative stress
Silver nanoparticles

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10.1088/2053-1591/1/4/045007

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title = "Facile fabrication of graphene oxide loaded with silver nanoparticles as antifungal materials",

abstract = "Graphene oxide loaded silver nanoparticles (GO-Ag) were synthesized using a simple method. Our evidence showed that silver nanoparticles (Ag NPs) were successfully loaded on the surface of graphene oxide sheets. The antifungal property of GO-Ag composites was investigated. The results revealed that the obtained GO-Ag composites exhibit enhanced antifungal property in comparison with that of Ag NPs. The toxicity of GO-Ag and Ag NPs were systematically evaluated. The study of cell viability, lactate dehydrogenase, reactive oxygen species, apoptosis/necrosis and hemolysis revealed that GO-Ag composites have lower cytotoxicity and better blood compatibility than Ag NPs. Therefore, these findings provide nanotoxicological information regarding GO-Ag composites which may be alternative antifungal materials in their application of biomedical fields.",

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T1 - Facile fabrication of graphene oxide loaded with silver nanoparticles as antifungal materials

AU - Cui, Jianghu

AU - Yang, Yunhua

AU - Zheng, Mingtao

AU - Liu, Yingliang

AU - Xiao, Yong

AU - Lei, Bingfu

AU - Chen, Wei

PY - 2015/12

Y1 - 2015/12

N2 - Graphene oxide loaded silver nanoparticles (GO-Ag) were synthesized using a simple method. Our evidence showed that silver nanoparticles (Ag NPs) were successfully loaded on the surface of graphene oxide sheets. The antifungal property of GO-Ag composites was investigated. The results revealed that the obtained GO-Ag composites exhibit enhanced antifungal property in comparison with that of Ag NPs. The toxicity of GO-Ag and Ag NPs were systematically evaluated. The study of cell viability, lactate dehydrogenase, reactive oxygen species, apoptosis/necrosis and hemolysis revealed that GO-Ag composites have lower cytotoxicity and better blood compatibility than Ag NPs. Therefore, these findings provide nanotoxicological information regarding GO-Ag composites which may be alternative antifungal materials in their application of biomedical fields.

AB - Graphene oxide loaded silver nanoparticles (GO-Ag) were synthesized using a simple method. Our evidence showed that silver nanoparticles (Ag NPs) were successfully loaded on the surface of graphene oxide sheets. The antifungal property of GO-Ag composites was investigated. The results revealed that the obtained GO-Ag composites exhibit enhanced antifungal property in comparison with that of Ag NPs. The toxicity of GO-Ag and Ag NPs were systematically evaluated. The study of cell viability, lactate dehydrogenase, reactive oxygen species, apoptosis/necrosis and hemolysis revealed that GO-Ag composites have lower cytotoxicity and better blood compatibility than Ag NPs. Therefore, these findings provide nanotoxicological information regarding GO-Ag composites which may be alternative antifungal materials in their application of biomedical fields.

KW - Antifungal

KW - Apoptosis

KW - Graphene oxide

KW - Hemolysis

KW - Oxidative stress

KW - Silver nanoparticles

UR - https://www.scopus.com/pages/publications/84953314228

U2 - 10.1088/2053-1591/1/4/045007

DO - 10.1088/2053-1591/1/4/045007

M3 - Article

AN - SCOPUS:84953314228

SN - 2053-1591

VL - 1

JO - Materials Research Express

JF - Materials Research Express

IS - 4

M1 - 045007

ER -

Facile fabrication of graphene oxide loaded with silver nanoparticles as antifungal materials

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Keywords

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