Effects of Sr and Mg dopants on biological and mechanical properties of SiO2–CaO–P2O5 bioactive glass

Fariborz Sharifianjazi; Mostafa Moradi; Aliasghar Abouchenari; Amir Hossein Pakseresht; Amirhossein Esmaeilkhanian; Mohammadreza Shokouhimehr; Mehdi Shahedi Asl

doi:10.1016/j.ceramint.2020.06.030

Effects of Sr and Mg dopants on biological and mechanical properties of SiO₂–CaO–P₂O₅ bioactive glass

Fariborz Sharifianjazi^*
, Mostafa Moradi
, Aliasghar Abouchenari
, Amir Hossein Pakseresht
, Amirhossein Esmaeilkhanian
, Mohammadreza Shokouhimehr
, Mehdi Shahedi Asl^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

In the present study, the effects of Sr and Mg were investigated on mechanical and biological properties of 58S bioactive glass (BG). SiO₂-P₂O₅-CaO BG with different contents of Sr and Mg were synthesized via the sol-gel method and immersed in simulated body fluid (SBF) for several days to explore their biocompatibility. Precise analyses of the BG using X-ray powder diffraction, scanning electron microscopy, and transmission electron microscopy showed that the Mg-doped BG containing 8 wt % MgO possessed better biocompatibility. It was also found that mechanical properties of the BG could be improved by increasing the amounts of MgO and SrO. Both 5Sr-BG and 8Mg-BG samples did not exhibit any cytotoxicity while showing high alkaline phosphatase activity in comparison with control specimens. However, the Sr-doped BG sample including 5 wt % SrO demonstrated enhanced bioactivity and biocompatibility.

Original language	English
Pages (from-to)	22674-22682
Number of pages	9
Journal	Ceramics International
Volume	46
Issue number	14
DOIs	https://doi.org/10.1016/j.ceramint.2020.06.030
Publication status	Published - 1 Oct 2020
Externally published	Yes

Keywords

Bioactive glass
Bioactivity
Biocompatibility
Magnesium
Mechanical properties
Strontium

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10.1016/j.ceramint.2020.06.030

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title = "Effects of Sr and Mg dopants on biological and mechanical properties of SiO2–CaO–P2O5 bioactive glass",

abstract = "In the present study, the effects of Sr and Mg were investigated on mechanical and biological properties of 58S bioactive glass (BG). SiO2-P2O5-CaO BG with different contents of Sr and Mg were synthesized via the sol-gel method and immersed in simulated body fluid (SBF) for several days to explore their biocompatibility. Precise analyses of the BG using X-ray powder diffraction, scanning electron microscopy, and transmission electron microscopy showed that the Mg-doped BG containing 8 wt \% MgO possessed better biocompatibility. It was also found that mechanical properties of the BG could be improved by increasing the amounts of MgO and SrO. Both 5Sr-BG and 8Mg-BG samples did not exhibit any cytotoxicity while showing high alkaline phosphatase activity in comparison with control specimens. However, the Sr-doped BG sample including 5 wt \% SrO demonstrated enhanced bioactivity and biocompatibility.",

keywords = "Bioactive glass, Bioactivity, Biocompatibility, Magnesium, Mechanical properties, Strontium",

author = "Fariborz Sharifianjazi and Mostafa Moradi and Aliasghar Abouchenari and Pakseresht, \{Amir Hossein\} and Amirhossein Esmaeilkhanian and Mohammadreza Shokouhimehr and \{Shahedi Asl\}, Mehdi",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd and Techna Group S.r.l.",

year = "2020",

month = oct,

day = "1",

doi = "10.1016/j.ceramint.2020.06.030",

language = "English",

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TY - JOUR

T1 - Effects of Sr and Mg dopants on biological and mechanical properties of SiO2–CaO–P2O5 bioactive glass

AU - Sharifianjazi, Fariborz

AU - Moradi, Mostafa

AU - Abouchenari, Aliasghar

AU - Pakseresht, Amir Hossein

AU - Esmaeilkhanian, Amirhossein

AU - Shokouhimehr, Mohammadreza

AU - Shahedi Asl, Mehdi

PY - 2020/10/1

Y1 - 2020/10/1

N2 - In the present study, the effects of Sr and Mg were investigated on mechanical and biological properties of 58S bioactive glass (BG). SiO2-P2O5-CaO BG with different contents of Sr and Mg were synthesized via the sol-gel method and immersed in simulated body fluid (SBF) for several days to explore their biocompatibility. Precise analyses of the BG using X-ray powder diffraction, scanning electron microscopy, and transmission electron microscopy showed that the Mg-doped BG containing 8 wt % MgO possessed better biocompatibility. It was also found that mechanical properties of the BG could be improved by increasing the amounts of MgO and SrO. Both 5Sr-BG and 8Mg-BG samples did not exhibit any cytotoxicity while showing high alkaline phosphatase activity in comparison with control specimens. However, the Sr-doped BG sample including 5 wt % SrO demonstrated enhanced bioactivity and biocompatibility.

AB - In the present study, the effects of Sr and Mg were investigated on mechanical and biological properties of 58S bioactive glass (BG). SiO2-P2O5-CaO BG with different contents of Sr and Mg were synthesized via the sol-gel method and immersed in simulated body fluid (SBF) for several days to explore their biocompatibility. Precise analyses of the BG using X-ray powder diffraction, scanning electron microscopy, and transmission electron microscopy showed that the Mg-doped BG containing 8 wt % MgO possessed better biocompatibility. It was also found that mechanical properties of the BG could be improved by increasing the amounts of MgO and SrO. Both 5Sr-BG and 8Mg-BG samples did not exhibit any cytotoxicity while showing high alkaline phosphatase activity in comparison with control specimens. However, the Sr-doped BG sample including 5 wt % SrO demonstrated enhanced bioactivity and biocompatibility.

KW - Bioactive glass

KW - Bioactivity

KW - Biocompatibility

KW - Magnesium

KW - Mechanical properties

KW - Strontium

UR - https://www.scopus.com/pages/publications/85086516426

U2 - 10.1016/j.ceramint.2020.06.030

DO - 10.1016/j.ceramint.2020.06.030

M3 - Article

AN - SCOPUS:85086516426

SN - 0272-8842

VL - 46

SP - 22674

EP - 22682

JO - Ceramics International

JF - Ceramics International

IS - 14

ER -

Effects of Sr and Mg dopants on biological and mechanical properties of SiO₂–CaO–P₂O₅ bioactive glass

Abstract

Keywords

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