EDTA and DTPA modified ligands as sequestering agents for uranyl decorporation

Antoine Leydier; Yi Lin; Guilhem Arrachart; Raphaël Turgis; Delphine Lecerclé; Alain Favre-Reguillon; Frédéric Taran; Marc Lemaire; Stéphane Pellet-Rostaing

doi:10.1016/j.tet.2011.11.065

EDTA and DTPA modified ligands as sequestering agents for uranyl decorporation

Antoine Leydier
, Yi Lin
, Guilhem Arrachart
, Raphaël Turgis
, Delphine Lecerclé
, Alain Favre-Reguillon
, Frédéric Taran
, Marc Lemaire
, Stéphane Pellet-Rostaing^*

^*Corresponding author for this work

Laboratoire de Catalyse et Synthèse Organique
Institut de Chimie Séparative de Marcoule
CEA-Saclay

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Synthesis of modified EDTA and DTPA ligands and determination of their binding affinities for the uranyl cation are described. Thanks to a screening method, based on a chromophoric complex displacement procedure, chelating properties were studied in aqueous media under various pH conditions for evaluation of their in vivo uranyl-removal efficacy. Each ligand showed a more or less pronounced affinity for uranium. Specific ligands based on EDTA or DTPA analogues containing sulfocatecholamide (CAMS) were found to exhibit a significant affinity towards uranyl ion in acidic, neutral or basic conditions.

Original language	English
Pages (from-to)	1163-1170
Number of pages	8
Journal	Tetrahedron
Volume	68
Issue number	4
DOIs	https://doi.org/10.1016/j.tet.2011.11.065
Publication status	Published - 28 Jan 2012
Externally published	Yes

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10.1016/j.tet.2011.11.065

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title = "EDTA and DTPA modified ligands as sequestering agents for uranyl decorporation",

abstract = "Synthesis of modified EDTA and DTPA ligands and determination of their binding affinities for the uranyl cation are described. Thanks to a screening method, based on a chromophoric complex displacement procedure, chelating properties were studied in aqueous media under various pH conditions for evaluation of their in vivo uranyl-removal efficacy. Each ligand showed a more or less pronounced affinity for uranium. Specific ligands based on EDTA or DTPA analogues containing sulfocatecholamide (CAMS) were found to exhibit a significant affinity towards uranyl ion in acidic, neutral or basic conditions.",

author = "Antoine Leydier and Yi Lin and Guilhem Arrachart and Rapha{\"e}l Turgis and Delphine Lecercl{\'e} and Alain Favre-Reguillon and Fr{\'e}d{\'e}ric Taran and Marc Lemaire and St{\'e}phane Pellet-Rostaing",

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doi = "10.1016/j.tet.2011.11.065",

language = "English",

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T1 - EDTA and DTPA modified ligands as sequestering agents for uranyl decorporation

AU - Leydier, Antoine

AU - Lin, Yi

AU - Arrachart, Guilhem

AU - Turgis, Raphaël

AU - Lecerclé, Delphine

AU - Favre-Reguillon, Alain

AU - Taran, Frédéric

AU - Lemaire, Marc

AU - Pellet-Rostaing, Stéphane

PY - 2012/1/28

Y1 - 2012/1/28

N2 - Synthesis of modified EDTA and DTPA ligands and determination of their binding affinities for the uranyl cation are described. Thanks to a screening method, based on a chromophoric complex displacement procedure, chelating properties were studied in aqueous media under various pH conditions for evaluation of their in vivo uranyl-removal efficacy. Each ligand showed a more or less pronounced affinity for uranium. Specific ligands based on EDTA or DTPA analogues containing sulfocatecholamide (CAMS) were found to exhibit a significant affinity towards uranyl ion in acidic, neutral or basic conditions.

AB - Synthesis of modified EDTA and DTPA ligands and determination of their binding affinities for the uranyl cation are described. Thanks to a screening method, based on a chromophoric complex displacement procedure, chelating properties were studied in aqueous media under various pH conditions for evaluation of their in vivo uranyl-removal efficacy. Each ligand showed a more or less pronounced affinity for uranium. Specific ligands based on EDTA or DTPA analogues containing sulfocatecholamide (CAMS) were found to exhibit a significant affinity towards uranyl ion in acidic, neutral or basic conditions.

UR - https://www.scopus.com/pages/publications/84855435852

U2 - 10.1016/j.tet.2011.11.065

DO - 10.1016/j.tet.2011.11.065

M3 - Article

AN - SCOPUS:84855435852

SN - 0040-4020

VL - 68

SP - 1163

EP - 1170

JO - Tetrahedron

JF - Tetrahedron

IS - 4

ER -

EDTA and DTPA modified ligands as sequestering agents for uranyl decorporation

Abstract

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