TY - JOUR
T1 - DNA damage response associated miRNA dysregulation in Ataxia-telangiectasia
AU - Iqbal, Muhammad Junaid
AU - Bucci, Cecilia
AU - Ricci, Anastasia
AU - Morganti, Gianluca
AU - Khan, Faez Iqbal
AU - Khan, Muhammad Jawad
AU - Menotta, Michele
PY - 2026/9
Y1 - 2026/9
N2 - Ataxia-telangiectasia (A-T) is a rare autosomal recessive genome-instability disorder due to pathogenic variants in ATM, a central kinase of the DNA double-strand break signaling, checkpoint activation and stress-response pathways. Although microRNAs (miRNAs) regulate DNA damage response (DDR), apoptosis, senescence and cell-cycle control, the stress-responsive behavior of selected ATM/DDR-associated miRNAs remains incompletely characterized in A-T fibroblast models.
AB - Ataxia-telangiectasia (A-T) is a rare autosomal recessive genome-instability disorder due to pathogenic variants in ATM, a central kinase of the DNA double-strand break signaling, checkpoint activation and stress-response pathways. Although microRNAs (miRNAs) regulate DNA damage response (DDR), apoptosis, senescence and cell-cycle control, the stress-responsive behavior of selected ATM/DDR-associated miRNAs remains incompletely characterized in A-T fibroblast models.
U2 - 10.1007/s11033-026-12860-1
DO - 10.1007/s11033-026-12860-1
M3 - Article
SN - 1573-4978
JO - Molecular Biology Reports
JF - Molecular Biology Reports
IS - 1
ER -