Design and Synthesis of Neomycin-Oxazolidinone Hybrid Antibiotics: Potent Agents Against Staphylococcus aureus and Escherichia coli, Exhibiting Synergistic Activity Against Pseudomonas aeruginosa via Outer Membrane Disruption

Yinzhe Chen; Weiding Wang; Wenbo Lu; Lifeng Ding; Ishwar Singh; Yongtao Zhu; Qian Zhang

Design and Synthesis of Neomycin-Oxazolidinone Hybrid Antibiotics: Potent Agents Against Staphylococcus aureus and Escherichia coli, Exhibiting Synergistic Activity Against Pseudomonas aeruginosa via Outer Membrane Disruption

Yinzhe Chen
, Weiding Wang
, Wenbo Lu
, Lifeng Ding
, Ishwar Singh
, Yongtao Zhu^*
, Qian Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Journal of Medicinal Chemistry
Publication status	Submitted - 2025

Cite this

@article{efe16dee7b034c02ba95e0e87f0610e3,

title = "Design and Synthesis of Neomycin-Oxazolidinone Hybrid Antibiotics: Potent Agents Against Staphylococcus aureus and Escherichia coli, Exhibiting Synergistic Activity Against Pseudomonas aeruginosa via Outer Membrane Disruption",

author = "Yinzhe Chen and Weiding Wang and Wenbo Lu and Lifeng Ding and Ishwar Singh and Yongtao Zhu and Qian Zhang",

year = "2025",

language = "English",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

}

Design and Synthesis of Neomycin-Oxazolidinone Hybrid Antibiotics: Potent Agents Against Staphylococcus aureus and Escherichia coli, Exhibiting Synergistic Activity Against Pseudomonas aeruginosa via Outer Membrane Disruption. / Chen, Yinzhe ; Wang, Weiding; Lu, Wenbo et al.
In: Journal of Medicinal Chemistry, 2025.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Design and Synthesis of Neomycin-Oxazolidinone Hybrid Antibiotics: Potent Agents Against Staphylococcus aureus and Escherichia coli, Exhibiting Synergistic Activity Against Pseudomonas aeruginosa via Outer Membrane Disruption

AU - Chen, Yinzhe

AU - Wang, Weiding

AU - Lu, Wenbo

AU - Ding, Lifeng

AU - Singh, Ishwar

AU - Zhu, Yongtao

AU - Zhang, Qian

PY - 2025

Y1 - 2025

M3 - Article

SN - 0022-2623

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

ER -