Database Construction and AI Design of Bioink for 3D Bio-printing

The similarities of organoids to actual organs make them more attractive for target identification and validation early in the pipeline, whereas organs-on-a-chip as more-reproducible and more-controllable engineered constructs are better suited for efficacy and safety screening. Generally, the National Key Research and Development Program (NKRDP) Project is to combine the multidisciplinary advances of experimental (biomaterials and 3D bio-printing, microfluidic chip and organoids) and computational (machine learning and simulation) technologies to provide theoretical support for cancer research progressing and organoids-on-chip products for reliable and cost-effective drug discovery. Dr Xue’s project belongs to the Work Packages IV of the NKRDP, the aims of which are 1) to investigate smart bioink materials for construction of tumor organoids by 3D bioprinting, and the structure-function interlink between the microscopic and macroscopic properties and 3D printability; and 2) to develop multi-fidelity database and machine learning model for 3D bioprinting and organoids-on-chip design. In this talk, she will give a brief overview of the research background, the current progress and the conclusion of the research output so far, and an outline of the future work plan.