Chromosomal and Plasmid-Borne Tigecycline Resistance Genes tet(X3) and tet(X4) in Dairy Cows on a Chinese Farm

Rong Zhang; Ning Dong; Yu Zeng; Zhangqi Shen; Jiayue Lu; Congcong Liu; Zhuo An Huang; Qiaoling Sun; Qipeng Cheng; Lingbin Shu; Jiachang Cai; Edward Waichi Chan; Dejun Liu; Gongxiang Chen; Yang Wang; Sheng Chen

doi:10.1128/AAC.00674-20

Chromosomal and Plasmid-Borne Tigecycline Resistance Genes tet(X3) and tet(X4) in Dairy Cows on a Chinese Farm

Rong Zhang
, Ning Dong
, Yu Zeng
, Zhangqi Shen
, Jiayue Lu
, Congcong Liu
, Zhuo An Huang
, Qiaoling Sun
, Qipeng Cheng
, Lingbin Shu
, Jiachang Cai
, Edward Waichi Chan
, Dejun Liu
, Gongxiang Chen
, Yang Wang^*
, Sheng Chen^*

^*Corresponding author for this work

Zhejiang University
City University of Hong Kong
China Agricultural University
Hong Kong Polytechnic University

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

We isolated 47 Acinetobacter strains carrying tet(X3) and 4 ST767 E. coli strains carrying tet(X4) from 296 rectal swab samples from dairy cows on a Chinese farm. tet(X3) was located on chromosomes or diverse plasmids, and tet(X4) was located on IncFIBΚ/FIA(HI1)/X1 nontransferable plasmid. The coexistence of tet(X3) and carbapenemase genes, including bla_OXA-58 and bla_NDM-1, was detected in 9 Acinetobacter spp. These findings suggested that the use of tetracycline and other antibiotics in food production warrants urgent attention.

Original language	English
Article number	e00674
Journal	Antimicrobial Agents and Chemotherapy
Volume	64
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00674-20
Publication status	Published - Oct 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 2 Zero Hunger
SDG 3 Good Health and Well-being

Keywords

Acinetobacter spp
Dairy cow
E. coli
Epidemiology
GI tract
Tet(X3)
Tet(X4)
Tigecycline
WGS

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10.1128/AAC.00674-20

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Zhang, R., Dong, N., Zeng, Y., Shen, Z., Lu, J., Liu, C., Huang, Z. A., Sun, Q., Cheng, Q., Shu, L., Cai, J., Chan, E. W., Liu, D., Chen, G., Wang, Y., & Chen, S. (2020). Chromosomal and Plasmid-Borne Tigecycline Resistance Genes tet(X3) and tet(X4) in Dairy Cows on a Chinese Farm. Antimicrobial Agents and Chemotherapy, 64(11), Article e00674. https://doi.org/10.1128/AAC.00674-20

@article{460f0576b68d4f76b5b044a325e72efd,

title = "Chromosomal and Plasmid-Borne Tigecycline Resistance Genes tet(X3) and tet(X4) in Dairy Cows on a Chinese Farm",

abstract = "We isolated 47 Acinetobacter strains carrying tet(X3) and 4 ST767 E. coli strains carrying tet(X4) from 296 rectal swab samples from dairy cows on a Chinese farm. tet(X3) was located on chromosomes or diverse plasmids, and tet(X4) was located on IncFIBΚ/FIA(HI1)/X1 nontransferable plasmid. The coexistence of tet(X3) and carbapenemase genes, including blaOXA-58 and blaNDM-1, was detected in 9 Acinetobacter spp. These findings suggested that the use of tetracycline and other antibiotics in food production warrants urgent attention.",

keywords = "Acinetobacter spp, Dairy cow, E. coli, Epidemiology, GI tract, Tet(X3), Tet(X4), Tigecycline, WGS",

author = "Rong Zhang and Ning Dong and Yu Zeng and Zhangqi Shen and Jiayue Lu and Congcong Liu and Huang, \{Zhuo An\} and Qiaoling Sun and Qipeng Cheng and Lingbin Shu and Jiachang Cai and Chan, \{Edward Waichi\} and Dejun Liu and Gongxiang Chen and Yang Wang and Sheng Chen",

year = "2020",

month = oct,

doi = "10.1128/AAC.00674-20",

language = "English",

volume = "64",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

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TY - JOUR

T1 - Chromosomal and Plasmid-Borne Tigecycline Resistance Genes tet(X3) and tet(X4) in Dairy Cows on a Chinese Farm

AU - Zhang, Rong

AU - Dong, Ning

AU - Zeng, Yu

AU - Shen, Zhangqi

AU - Lu, Jiayue

AU - Liu, Congcong

AU - Huang, Zhuo An

AU - Sun, Qiaoling

AU - Cheng, Qipeng

AU - Shu, Lingbin

AU - Cai, Jiachang

AU - Chan, Edward Waichi

AU - Liu, Dejun

AU - Chen, Gongxiang

AU - Wang, Yang

AU - Chen, Sheng

PY - 2020/10

Y1 - 2020/10

N2 - We isolated 47 Acinetobacter strains carrying tet(X3) and 4 ST767 E. coli strains carrying tet(X4) from 296 rectal swab samples from dairy cows on a Chinese farm. tet(X3) was located on chromosomes or diverse plasmids, and tet(X4) was located on IncFIBΚ/FIA(HI1)/X1 nontransferable plasmid. The coexistence of tet(X3) and carbapenemase genes, including blaOXA-58 and blaNDM-1, was detected in 9 Acinetobacter spp. These findings suggested that the use of tetracycline and other antibiotics in food production warrants urgent attention.

AB - We isolated 47 Acinetobacter strains carrying tet(X3) and 4 ST767 E. coli strains carrying tet(X4) from 296 rectal swab samples from dairy cows on a Chinese farm. tet(X3) was located on chromosomes or diverse plasmids, and tet(X4) was located on IncFIBΚ/FIA(HI1)/X1 nontransferable plasmid. The coexistence of tet(X3) and carbapenemase genes, including blaOXA-58 and blaNDM-1, was detected in 9 Acinetobacter spp. These findings suggested that the use of tetracycline and other antibiotics in food production warrants urgent attention.

KW - Acinetobacter spp

KW - Dairy cow

KW - E. coli

KW - Epidemiology

KW - GI tract

KW - Tet(X3)

KW - Tet(X4)

KW - Tigecycline

KW - WGS

UR - https://www.scopus.com/pages/publications/85094222363

U2 - 10.1128/AAC.00674-20

DO - 10.1128/AAC.00674-20

M3 - Article

C2 - 32816739

AN - SCOPUS:85094222363

SN - 0066-4804

VL - 64

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

M1 - e00674

ER -

Chromosomal and Plasmid-Borne Tigecycline Resistance Genes tet(X3) and tet(X4) in Dairy Cows on a Chinese Farm

Abstract

UN SDGs

Keywords

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