Association study of dopamine receptor genes polymorphisms with the risk of schizophrenia in the Han Chinese population

Beimeng Yang; Weibo Niu; Shiqing Chen; Fei Xu; Xingwang Li; Xi Wu; Yanfei Cao; Rui Zhang; Fengping Yang; Lu Wang; Weidong Li; Yifeng Xu; Lin He; Guang He

doi:10.1016/j.psychres.2016.08.052

Association study of dopamine receptor genes polymorphisms with the risk of schizophrenia in the Han Chinese population

Beimeng Yang
, Weibo Niu
, Shiqing Chen
, Fei Xu
, Xingwang Li
, Xi Wu
, Yanfei Cao
, Rui Zhang
, Fengping Yang
, Lu Wang
, Weidong Li
, Yifeng Xu
, Lin He
, Guang He^*

^*Corresponding author for this work

Shanghai Jiao Tong University
CAS - Shanghai Institute of Nutrition and Health
Shantou University

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Schizophrenia is a highly heritable psychiatric disorder often associated with dopamine-related genetic variations. Thus, we performed a case-control study in 1504 Han Chinese population to evaluate the association of DRD1, DRD2 and DRD3 polymorphisms with schizophrenia. No statistically significant difference in allelic or genotypic frequency was found between schizophrenia and control subjects. Strong positive linkage disequilibrium was detected among the SNPs within DRD1 and DRD2. However, no positive haplotype distribution was found to be associated with schizophrenia. Our results indicated that DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population.

Original language	English
Pages (from-to)	361-364
Number of pages	4
Journal	Psychiatry Research
Volume	245
DOIs	https://doi.org/10.1016/j.psychres.2016.08.052
Publication status	Published - 30 Nov 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DRD1
DRD2
DRD3

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10.1016/j.psychres.2016.08.052

Cite this

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title = "Association study of dopamine receptor genes polymorphisms with the risk of schizophrenia in the Han Chinese population",

abstract = "Schizophrenia is a highly heritable psychiatric disorder often associated with dopamine-related genetic variations. Thus, we performed a case-control study in 1504 Han Chinese population to evaluate the association of DRD1, DRD2 and DRD3 polymorphisms with schizophrenia. No statistically significant difference in allelic or genotypic frequency was found between schizophrenia and control subjects. Strong positive linkage disequilibrium was detected among the SNPs within DRD1 and DRD2. However, no positive haplotype distribution was found to be associated with schizophrenia. Our results indicated that DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population.",

keywords = "DRD1, DRD2, DRD3",

author = "Beimeng Yang and Weibo Niu and Shiqing Chen and Fei Xu and Xingwang Li and Xi Wu and Yanfei Cao and Rui Zhang and Fengping Yang and Lu Wang and Weidong Li and Yifeng Xu and Lin He and Guang He",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ireland Ltd",

year = "2016",

month = nov,

day = "30",

doi = "10.1016/j.psychres.2016.08.052",

language = "English",

volume = "245",

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journal = "Psychiatry Research",

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TY - JOUR

T1 - Association study of dopamine receptor genes polymorphisms with the risk of schizophrenia in the Han Chinese population

AU - Yang, Beimeng

AU - Niu, Weibo

AU - Chen, Shiqing

AU - Xu, Fei

AU - Li, Xingwang

AU - Wu, Xi

AU - Cao, Yanfei

AU - Zhang, Rui

AU - Yang, Fengping

AU - Wang, Lu

AU - Li, Weidong

AU - Xu, Yifeng

AU - He, Lin

AU - He, Guang

PY - 2016/11/30

Y1 - 2016/11/30

N2 - Schizophrenia is a highly heritable psychiatric disorder often associated with dopamine-related genetic variations. Thus, we performed a case-control study in 1504 Han Chinese population to evaluate the association of DRD1, DRD2 and DRD3 polymorphisms with schizophrenia. No statistically significant difference in allelic or genotypic frequency was found between schizophrenia and control subjects. Strong positive linkage disequilibrium was detected among the SNPs within DRD1 and DRD2. However, no positive haplotype distribution was found to be associated with schizophrenia. Our results indicated that DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population.

AB - Schizophrenia is a highly heritable psychiatric disorder often associated with dopamine-related genetic variations. Thus, we performed a case-control study in 1504 Han Chinese population to evaluate the association of DRD1, DRD2 and DRD3 polymorphisms with schizophrenia. No statistically significant difference in allelic or genotypic frequency was found between schizophrenia and control subjects. Strong positive linkage disequilibrium was detected among the SNPs within DRD1 and DRD2. However, no positive haplotype distribution was found to be associated with schizophrenia. Our results indicated that DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population.

KW - DRD1

KW - DRD2

KW - DRD3

UR - https://www.scopus.com/pages/publications/84984691665

U2 - 10.1016/j.psychres.2016.08.052

DO - 10.1016/j.psychres.2016.08.052

M3 - Article

C2 - 27591410

AN - SCOPUS:84984691665

SN - 0165-1781

VL - 245

SP - 361

EP - 364

JO - Psychiatry Research

JF - Psychiatry Research

ER -

Association study of dopamine receptor genes polymorphisms with the risk of schizophrenia in the Han Chinese population

Abstract

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Keywords

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