Association study of APC polymorphisms with colorectal cancer in Han Chinese

Xiaoye Huang; Yang Wang; Tao Yu; Baocheng Liu; Xin Li; Weidong Li; Shiqing Chen; Qingzhu Zhao; Xingwang Li; Fengping Yang; Quan Wang; Jinfen Wang; Yanzeng Xiao; Yifeng Xu; Guoyin Feng; Zhihai Peng; Lin He; Guang He

doi:10.1016/j.clinbiochem.2012.07.001

Association study of APC polymorphisms with colorectal cancer in Han Chinese

Xiaoye Huang
, Yang Wang
, Tao Yu
, Baocheng Liu
, Xin Li
, Weidong Li
, Shiqing Chen
, Qingzhu Zhao
, Xingwang Li
, Fengping Yang
, Quan Wang
, Jinfen Wang
, Yanzeng Xiao
, Yifeng Xu
, Guoyin Feng
, Zhihai Peng^*
, Lin He
, Guang He

^*Corresponding author for this work

Shanghai Jiao Tong University
Shanghai Genome Pilot Institutes for Genomics and Human Health
CAS - Shanghai Institute of Nutrition and Health
Shanxi Cancer Hospital
Fudan University

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objectives: Colorectal cancer (CRC) is a common malignancy with worldwide prevalence. Familial adenomatous polyposis (FAP), a predisposition syndrome of CRC, is caused by germ line mutations in the APC gene. Mutations in APC are thought to be an early event in colorectal tumorigenesis. We hypothesized that common variants in APC might be associated with CRC. Design and methods: A case-control study genotyping ten SNPs was conducted in 312 CRC patients and 270 normal controls in the Chinese Han population. Results: The genotype frequency of rs2019720 showed a significant difference between cases and controls (p = 0.046, after Bonferroni correction). For the three pairs of SNPs in strong LD, we carried out haplotype analyses but no significant association was detected. Conclusion: Our results suggest that APC polymorphisms might be associated with CRC in the Chinese Han population.

Original language	English
Pages (from-to)	1669-1672
Number of pages	4
Journal	Clinical Biochemistry
Volume	45
Issue number	18
DOIs	https://doi.org/10.1016/j.clinbiochem.2012.07.001
Publication status	Published - Dec 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

APC gene
Association
Chinese Han population
Colorectal cancer

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10.1016/j.clinbiochem.2012.07.001

Cite this

@article{8b07e80132a443369428145537596ab1,

title = "Association study of APC polymorphisms with colorectal cancer in Han Chinese",

abstract = "Objectives: Colorectal cancer (CRC) is a common malignancy with worldwide prevalence. Familial adenomatous polyposis (FAP), a predisposition syndrome of CRC, is caused by germ line mutations in the APC gene. Mutations in APC are thought to be an early event in colorectal tumorigenesis. We hypothesized that common variants in APC might be associated with CRC. Design and methods: A case-control study genotyping ten SNPs was conducted in 312 CRC patients and 270 normal controls in the Chinese Han population. Results: The genotype frequency of rs2019720 showed a significant difference between cases and controls (p = 0.046, after Bonferroni correction). For the three pairs of SNPs in strong LD, we carried out haplotype analyses but no significant association was detected. Conclusion: Our results suggest that APC polymorphisms might be associated with CRC in the Chinese Han population.",

keywords = "APC gene, Association, Chinese Han population, Colorectal cancer",

author = "Xiaoye Huang and Yang Wang and Tao Yu and Baocheng Liu and Xin Li and Weidong Li and Shiqing Chen and Qingzhu Zhao and Xingwang Li and Fengping Yang and Quan Wang and Jinfen Wang and Yanzeng Xiao and Yifeng Xu and Guoyin Feng and Zhihai Peng and Lin He and Guang He",

year = "2012",

month = dec,

doi = "10.1016/j.clinbiochem.2012.07.001",

language = "English",

volume = "45",

pages = "1669--1672",

journal = "Clinical Biochemistry",

issn = "0009-9120",

number = "18",

}

TY - JOUR

T1 - Association study of APC polymorphisms with colorectal cancer in Han Chinese

AU - Huang, Xiaoye

AU - Wang, Yang

AU - Yu, Tao

AU - Liu, Baocheng

AU - Li, Xin

AU - Li, Weidong

AU - Chen, Shiqing

AU - Zhao, Qingzhu

AU - Li, Xingwang

AU - Yang, Fengping

AU - Wang, Quan

AU - Wang, Jinfen

AU - Xiao, Yanzeng

AU - Xu, Yifeng

AU - Feng, Guoyin

AU - Peng, Zhihai

AU - He, Lin

AU - He, Guang

PY - 2012/12

Y1 - 2012/12

N2 - Objectives: Colorectal cancer (CRC) is a common malignancy with worldwide prevalence. Familial adenomatous polyposis (FAP), a predisposition syndrome of CRC, is caused by germ line mutations in the APC gene. Mutations in APC are thought to be an early event in colorectal tumorigenesis. We hypothesized that common variants in APC might be associated with CRC. Design and methods: A case-control study genotyping ten SNPs was conducted in 312 CRC patients and 270 normal controls in the Chinese Han population. Results: The genotype frequency of rs2019720 showed a significant difference between cases and controls (p = 0.046, after Bonferroni correction). For the three pairs of SNPs in strong LD, we carried out haplotype analyses but no significant association was detected. Conclusion: Our results suggest that APC polymorphisms might be associated with CRC in the Chinese Han population.

AB - Objectives: Colorectal cancer (CRC) is a common malignancy with worldwide prevalence. Familial adenomatous polyposis (FAP), a predisposition syndrome of CRC, is caused by germ line mutations in the APC gene. Mutations in APC are thought to be an early event in colorectal tumorigenesis. We hypothesized that common variants in APC might be associated with CRC. Design and methods: A case-control study genotyping ten SNPs was conducted in 312 CRC patients and 270 normal controls in the Chinese Han population. Results: The genotype frequency of rs2019720 showed a significant difference between cases and controls (p = 0.046, after Bonferroni correction). For the three pairs of SNPs in strong LD, we carried out haplotype analyses but no significant association was detected. Conclusion: Our results suggest that APC polymorphisms might be associated with CRC in the Chinese Han population.

KW - APC gene

KW - Association

KW - Chinese Han population

KW - Colorectal cancer

UR - https://www.scopus.com/pages/publications/84870704398

U2 - 10.1016/j.clinbiochem.2012.07.001

DO - 10.1016/j.clinbiochem.2012.07.001

M3 - Article

C2 - 22796397

AN - SCOPUS:84870704398

SN - 0009-9120

VL - 45

SP - 1669

EP - 1672

JO - Clinical Biochemistry

JF - Clinical Biochemistry

IS - 18

ER -

Association study of APC polymorphisms with colorectal cancer in Han Chinese

Abstract

UN SDGs

Keywords

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