TY - JOUR
T1 - Association study of 5-HT1A, 5-HT2A polymorphisms with schizophrenia and major depressive disorder in the Han Chinese population
AU - Zhang, Rui
AU - Bi, Yan
AU - Niu, Weibo
AU - Huang, Xiaoye
AU - Chen, Shiqing
AU - Li, Xingwang
AU - Wu, Xi
AU - Cao, Yanfei
AU - Yang, Fengping
AU - Wang, Lu
AU - Li, Weidong
AU - Xu, Yifeng
AU - He, Lin
AU - Yu, Tao
AU - He, Guang
N1 - Publisher Copyright:
© 2016 Elsevier Ireland Ltd
PY - 2016/12/2
Y1 - 2016/12/2
N2 - Schizophrenia (SZ) and major depressive disorder (MDD) are two common severe mental disorders that have arisen to public awareness in recent years. Serotonin (5-HT) receptors have been implicated in the pathophysiology of psychiatric disorders especially in MDD and SZ. The aim of this study is to explore whether the variants in the 5-HT1A and 5-HT2A gene are susceptible to SZ or MDD in the Chinese Han population. Five SNPs (Single Nucleotide Polymorphisms) (rs1364043, rs10042486, rs6313, rs6311, rs17289304) in these genes were genotyped from 752 SZ patients, 568 MDD patients, and 846 normal controls of Chinese Han origin. The results showed that the 5-HT1A rs10042486 was significantly associated with SZ (Pallele = 0.0369, Pgenotype = 0.0098). Moreover, the haplotype (C-T) composed of rs10042486 and rs1364043 showed significant difference between SZ cases and healthy controls (P = 0.0302) while another haplotype (T-G) was significant for MDD (P = 0.0247). Our study is the first to suggest a positive association of the 5-HT1A gene with SZ in the Han Chinese population.
AB - Schizophrenia (SZ) and major depressive disorder (MDD) are two common severe mental disorders that have arisen to public awareness in recent years. Serotonin (5-HT) receptors have been implicated in the pathophysiology of psychiatric disorders especially in MDD and SZ. The aim of this study is to explore whether the variants in the 5-HT1A and 5-HT2A gene are susceptible to SZ or MDD in the Chinese Han population. Five SNPs (Single Nucleotide Polymorphisms) (rs1364043, rs10042486, rs6313, rs6311, rs17289304) in these genes were genotyped from 752 SZ patients, 568 MDD patients, and 846 normal controls of Chinese Han origin. The results showed that the 5-HT1A rs10042486 was significantly associated with SZ (Pallele = 0.0369, Pgenotype = 0.0098). Moreover, the haplotype (C-T) composed of rs10042486 and rs1364043 showed significant difference between SZ cases and healthy controls (P = 0.0302) while another haplotype (T-G) was significant for MDD (P = 0.0247). Our study is the first to suggest a positive association of the 5-HT1A gene with SZ in the Han Chinese population.
KW - 5-HT1A
KW - 5-HT2A
KW - Association
KW - Major depressive disorder
KW - Schizophrenia
UR - https://www.scopus.com/pages/publications/84992560970
U2 - 10.1016/j.neulet.2016.10.018
DO - 10.1016/j.neulet.2016.10.018
M3 - Article
C2 - 27756686
AN - SCOPUS:84992560970
SN - 0304-3940
VL - 635
SP - 39
EP - 43
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -