Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates

Konstantinos Douroudis; Antti Pekka Laine; Mirkka Heinonen; Robert Hermann; Kati Lipponen; Riitta Veijola; Olli Simell; Mikael Knip; Raivo Uibo; Jorma Ilonen; Kalle Kisand

doi:10.1016/j.humimm.2009.04.023

Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates

Konstantinos Douroudis
, Antti Pekka Laine
, Mirkka Heinonen
, Robert Hermann
, Kati Lipponen
, Riitta Veijola
, Olli Simell
, Mikael Knip
, Raivo Uibo
, Jorma Ilonen
, Kalle Kisand^*

^*Corresponding author for this work

Immunology Group
University of Tartu
University of Turku
University of Oulu
University of Helsinki
Tampere University
University of Eastern Finland

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and inducible T-cell co-stimulator (ICOS) genes are important mediators of T-cell activation in autoimmune diseases. The aim of the current study was to assess the impact of CTLA-4 and ICOS genes on the susceptibility to type 1 diabetes among two populations with different disease incidence rates. Three single nucleotide polymorphisms (SNPs) within the CTLA-4 region (+49A/G, CT60A/G, CTBC217_1C/T) and two SNPs within the ICOS region (CTIC154_1 C/T, CTIC159 C/G) were genotyped in 955 control subjects and 574 diabetic patients of Estonian and Finnish descent. The current study confirms the involvement of the CTLA-4 but not the ICOS gene in susceptibility to type 1 diabetes. However, the risk alleles and the defined main risk haplotype were more common in the Finnish controls compared with the Estonians, indicating that this gene locus might also be one of the contributing factors to the higher disease incidence in Finland.

Original language	English
Pages (from-to)	536-539
Number of pages	4
Journal	Human Immunology
Volume	70
Issue number	7
DOIs	https://doi.org/10.1016/j.humimm.2009.04.023
Publication status	Published - Jul 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CTLA-4
ICOS
Type 1 diabetes

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10.1016/j.humimm.2009.04.023

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title = "Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates",

abstract = "Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and inducible T-cell co-stimulator (ICOS) genes are important mediators of T-cell activation in autoimmune diseases. The aim of the current study was to assess the impact of CTLA-4 and ICOS genes on the susceptibility to type 1 diabetes among two populations with different disease incidence rates. Three single nucleotide polymorphisms (SNPs) within the CTLA-4 region (+49A/G, CT60A/G, CTBC217\_1C/T) and two SNPs within the ICOS region (CTIC154\_1 C/T, CTIC159 C/G) were genotyped in 955 control subjects and 574 diabetic patients of Estonian and Finnish descent. The current study confirms the involvement of the CTLA-4 but not the ICOS gene in susceptibility to type 1 diabetes. However, the risk alleles and the defined main risk haplotype were more common in the Finnish controls compared with the Estonians, indicating that this gene locus might also be one of the contributing factors to the higher disease incidence in Finland.",

keywords = "CTLA-4, ICOS, Type 1 diabetes",

author = "Konstantinos Douroudis and Laine, \{Antti Pekka\} and Mirkka Heinonen and Robert Hermann and Kati Lipponen and Riitta Veijola and Olli Simell and Mikael Knip and Raivo Uibo and Jorma Ilonen and Kalle Kisand",

note = "Funding Information: This study was supported by Estonian Science Foundation grant no. 6514, no 7749, and by Foundation Innove and the Medical Research Council, Academy of Finland.",

year = "2009",

month = jul,

doi = "10.1016/j.humimm.2009.04.023",

language = "English",

volume = "70",

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T1 - Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates

AU - Douroudis, Konstantinos

AU - Laine, Antti Pekka

AU - Heinonen, Mirkka

AU - Hermann, Robert

AU - Lipponen, Kati

AU - Veijola, Riitta

AU - Simell, Olli

AU - Knip, Mikael

AU - Uibo, Raivo

AU - Ilonen, Jorma

AU - Kisand, Kalle

N1 - Funding Information: This study was supported by Estonian Science Foundation grant no. 6514, no 7749, and by Foundation Innove and the Medical Research Council, Academy of Finland.

PY - 2009/7

Y1 - 2009/7

N2 - Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and inducible T-cell co-stimulator (ICOS) genes are important mediators of T-cell activation in autoimmune diseases. The aim of the current study was to assess the impact of CTLA-4 and ICOS genes on the susceptibility to type 1 diabetes among two populations with different disease incidence rates. Three single nucleotide polymorphisms (SNPs) within the CTLA-4 region (+49A/G, CT60A/G, CTBC217_1C/T) and two SNPs within the ICOS region (CTIC154_1 C/T, CTIC159 C/G) were genotyped in 955 control subjects and 574 diabetic patients of Estonian and Finnish descent. The current study confirms the involvement of the CTLA-4 but not the ICOS gene in susceptibility to type 1 diabetes. However, the risk alleles and the defined main risk haplotype were more common in the Finnish controls compared with the Estonians, indicating that this gene locus might also be one of the contributing factors to the higher disease incidence in Finland.

AB - Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and inducible T-cell co-stimulator (ICOS) genes are important mediators of T-cell activation in autoimmune diseases. The aim of the current study was to assess the impact of CTLA-4 and ICOS genes on the susceptibility to type 1 diabetes among two populations with different disease incidence rates. Three single nucleotide polymorphisms (SNPs) within the CTLA-4 region (+49A/G, CT60A/G, CTBC217_1C/T) and two SNPs within the ICOS region (CTIC154_1 C/T, CTIC159 C/G) were genotyped in 955 control subjects and 574 diabetic patients of Estonian and Finnish descent. The current study confirms the involvement of the CTLA-4 but not the ICOS gene in susceptibility to type 1 diabetes. However, the risk alleles and the defined main risk haplotype were more common in the Finnish controls compared with the Estonians, indicating that this gene locus might also be one of the contributing factors to the higher disease incidence in Finland.

KW - CTLA-4

KW - ICOS

KW - Type 1 diabetes

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U2 - 10.1016/j.humimm.2009.04.023

DO - 10.1016/j.humimm.2009.04.023

M3 - Article

C2 - 19376178

AN - SCOPUS:67449126845

SN - 0198-8859

VL - 70

SP - 536

EP - 539

JO - Human Immunology

JF - Human Immunology

IS - 7

ER -

Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates

Abstract

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Keywords

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