Analysis of the association of VIPR2 polymorphisms with susceptibility to schizophrenia

Chunhui Jin; Zhenhe Zhou; Weidong Li; Fuquan Zhang; Jianmin Yuan; Xiaowei Liu; Zaohuo Cheng

doi:10.1016/j.psychres.2016.04.084

Analysis of the association of VIPR2 polymorphisms with susceptibility to schizophrenia

Chunhui Jin^*
, Zhenhe Zhou
, Weidong Li
, Fuquan Zhang
, Jianmin Yuan
, Xiaowei Liu
, Zaohuo Cheng

^*Corresponding author for this work

Nanjing Medical University
Jiangsu Institute of Psychology
Shanghai Jiao Tong University

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In a previous study, we confirmed that copy number variants (CNVs) within the VIPR2 gene in Han Chinese individuals exhibit an increased risk of schizophrenia (SCZ). Herein, we further analyzed the association of eight tagged single nucleotide polymorphisms (tagSNPs) from the HapMap database with SCZ susceptibility. However, we found no significant positive signals in overall association and haplotypes analyses. Interestingly, significant SNP-SNP interaction signals associated with the risk of SCZ were observed using Multifactor Dimensionality Reduction (MDR) analysis. Furthermore, the 'CC' genotype of the VIPR2 gene was nominally associated with an increased risk of SCZ in male patients.

Original language	English
Pages (from-to)	104-107
Number of pages	4
Journal	Psychiatry Research
Volume	241
DOIs	https://doi.org/10.1016/j.psychres.2016.04.084
Publication status	Published - 30 Jul 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Han Chinese
Schizophrenia
VIPR2

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10.1016/j.psychres.2016.04.084

Cite this

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title = "Analysis of the association of VIPR2 polymorphisms with susceptibility to schizophrenia",

abstract = "In a previous study, we confirmed that copy number variants (CNVs) within the VIPR2 gene in Han Chinese individuals exhibit an increased risk of schizophrenia (SCZ). Herein, we further analyzed the association of eight tagged single nucleotide polymorphisms (tagSNPs) from the HapMap database with SCZ susceptibility. However, we found no significant positive signals in overall association and haplotypes analyses. Interestingly, significant SNP-SNP interaction signals associated with the risk of SCZ were observed using Multifactor Dimensionality Reduction (MDR) analysis. Furthermore, the 'CC' genotype of the VIPR2 gene was nominally associated with an increased risk of SCZ in male patients.",

keywords = "Han Chinese, Schizophrenia, VIPR2",

author = "Chunhui Jin and Zhenhe Zhou and Weidong Li and Fuquan Zhang and Jianmin Yuan and Xiaowei Liu and Zaohuo Cheng",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ireland Ltd.",

year = "2016",

month = jul,

day = "30",

doi = "10.1016/j.psychres.2016.04.084",

language = "English",

volume = "241",

pages = "104--107",

journal = "Psychiatry Research",

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TY - JOUR

T1 - Analysis of the association of VIPR2 polymorphisms with susceptibility to schizophrenia

AU - Jin, Chunhui

AU - Zhou, Zhenhe

AU - Li, Weidong

AU - Zhang, Fuquan

AU - Yuan, Jianmin

AU - Liu, Xiaowei

AU - Cheng, Zaohuo

PY - 2016/7/30

Y1 - 2016/7/30

N2 - In a previous study, we confirmed that copy number variants (CNVs) within the VIPR2 gene in Han Chinese individuals exhibit an increased risk of schizophrenia (SCZ). Herein, we further analyzed the association of eight tagged single nucleotide polymorphisms (tagSNPs) from the HapMap database with SCZ susceptibility. However, we found no significant positive signals in overall association and haplotypes analyses. Interestingly, significant SNP-SNP interaction signals associated with the risk of SCZ were observed using Multifactor Dimensionality Reduction (MDR) analysis. Furthermore, the 'CC' genotype of the VIPR2 gene was nominally associated with an increased risk of SCZ in male patients.

AB - In a previous study, we confirmed that copy number variants (CNVs) within the VIPR2 gene in Han Chinese individuals exhibit an increased risk of schizophrenia (SCZ). Herein, we further analyzed the association of eight tagged single nucleotide polymorphisms (tagSNPs) from the HapMap database with SCZ susceptibility. However, we found no significant positive signals in overall association and haplotypes analyses. Interestingly, significant SNP-SNP interaction signals associated with the risk of SCZ were observed using Multifactor Dimensionality Reduction (MDR) analysis. Furthermore, the 'CC' genotype of the VIPR2 gene was nominally associated with an increased risk of SCZ in male patients.

KW - Han Chinese

KW - Schizophrenia

KW - VIPR2

UR - https://www.scopus.com/pages/publications/84964958196

U2 - 10.1016/j.psychres.2016.04.084

DO - 10.1016/j.psychres.2016.04.084

M3 - Article

C2 - 27156032

AN - SCOPUS:84964958196

SN - 0165-1781

VL - 241

SP - 104

EP - 107

JO - Psychiatry Research

JF - Psychiatry Research

ER -

Analysis of the association of VIPR2 polymorphisms with susceptibility to schizophrenia

Abstract

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Keywords

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