Ammonia: A Metabolic Checkpoint for Treg Potency

Ali Valipour Motlagh; Eyad Elkord; Weiwei Dai

doi:10.1016/j.trecan.2026.02.002

Ammonia: A Metabolic Checkpoint for Treg Potency

Ali Valipour Motlagh
, Eyad Elkord^*
, Weiwei Dai^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Ammonia acts as a metabolic checkpoint fueling regulatory T cells (Tregs). Gu et al. demonstrate that utilizing argininosuccinate lyase-linked survival buffering and a FOXP3-spermine-PPARγ axis for mitochondrial reinforcement allows Tregs to convert toxic waste into suppressive power, driving tumor immune evasion and immunotherapy resistance.

Original language	English
Article number	TRECAN1133
Journal	Trends in Cancer
DOIs	https://doi.org/10.1016/j.trecan.2026.02.002
Publication status	Published - 7 Mar 2026

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10.1016/j.trecan.2026.02.002

Cite this

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title = "Ammonia: A Metabolic Checkpoint for Treg Potency",

abstract = "Ammonia acts as a metabolic checkpoint fueling regulatory T cells (Tregs). Gu et al. demonstrate that utilizing argininosuccinate lyase-linked survival buffering and a FOXP3-spermine-PPARγ axis for mitochondrial reinforcement allows Tregs to convert toxic waste into suppressive power, driving tumor immune evasion and immunotherapy resistance.",

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AB - Ammonia acts as a metabolic checkpoint fueling regulatory T cells (Tregs). Gu et al. demonstrate that utilizing argininosuccinate lyase-linked survival buffering and a FOXP3-spermine-PPARγ axis for mitochondrial reinforcement allows Tregs to convert toxic waste into suppressive power, driving tumor immune evasion and immunotherapy resistance.

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