Aberrantly regulated proteins in frontotemporal dementia

Kelly Schweitzer; Emily Decker; Liping Zhu; Richard E. Miller; Suzanne S. Mirra; Salvatore Spina; Bernardino Ghetti; Mu Wang; Jill Murrell

doi:10.1016/j.bbrc.2006.07.113

Aberrantly regulated proteins in frontotemporal dementia

Kelly Schweitzer^*
, Emily Decker
, Liping Zhu
, Richard E. Miller
, Suzanne S. Mirra
, Salvatore Spina
, Bernardino Ghetti
, Mu Wang
, Jill Murrell

^*Corresponding author for this work

Indiana University Bloomington
Wayne State University
SUNY

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.

Original language	English
Pages (from-to)	465-472
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	348
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2006.07.113
Publication status	Published - 22 Sept 2006
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Frontotemporal dementia and parkinsonism linked to chromosome 17
Matrix-assisted laser desorption/ionization time-of-flight
Oxidative stress
Two-dimensional electrophoresis
UCHL1
Ubiquitin C-terminal hydrolyase L1

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10.1016/j.bbrc.2006.07.113

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title = "Aberrantly regulated proteins in frontotemporal dementia",

abstract = "Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.",

keywords = "Frontotemporal dementia and parkinsonism linked to chromosome 17, Matrix-assisted laser desorption/ionization time-of-flight, Oxidative stress, Two-dimensional electrophoresis, UCHL1, Ubiquitin C-terminal hydrolyase L1",

author = "Kelly Schweitzer and Emily Decker and Liping Zhu and Miller, \{Richard E.\} and Mirra, \{Suzanne S.\} and Salvatore Spina and Bernardino Ghetti and Mu Wang and Jill Murrell",

note = "Funding Information: This research was supported by Public Health Service Grants RO1 NS37431 and P30 AG10133.",

year = "2006",

month = sep,

day = "22",

doi = "10.1016/j.bbrc.2006.07.113",

language = "English",

volume = "348",

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journal = "Biochemical and Biophysical Research Communications",

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TY - JOUR

T1 - Aberrantly regulated proteins in frontotemporal dementia

AU - Schweitzer, Kelly

AU - Decker, Emily

AU - Zhu, Liping

AU - Miller, Richard E.

AU - Mirra, Suzanne S.

AU - Spina, Salvatore

AU - Ghetti, Bernardino

AU - Wang, Mu

AU - Murrell, Jill

N1 - Funding Information: This research was supported by Public Health Service Grants RO1 NS37431 and P30 AG10133.

PY - 2006/9/22

Y1 - 2006/9/22

N2 - Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.

AB - Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.

KW - Frontotemporal dementia and parkinsonism linked to chromosome 17

KW - Matrix-assisted laser desorption/ionization time-of-flight

KW - Oxidative stress

KW - Two-dimensional electrophoresis

KW - UCHL1

KW - Ubiquitin C-terminal hydrolyase L1

UR - https://www.scopus.com/pages/publications/33746921194

U2 - 10.1016/j.bbrc.2006.07.113

DO - 10.1016/j.bbrc.2006.07.113

M3 - Article

C2 - 16890190

AN - SCOPUS:33746921194

SN - 0006-291X

VL - 348

SP - 465

EP - 472

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Aberrantly regulated proteins in frontotemporal dementia

Abstract

UN SDGs

Keywords

Access to Document

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