A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

Wenjun Li; Dongyuan Wang; Xiaodong Shi; Jingxu Li; Yue Ma; Yanding Wang; Tingting Li; Jianing Zhang; Rongtong Zhao; Zhiqiang Yu; Feng Yin; Zigang Li

doi:10.1039/c8mh00392k

A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

Wenjun Li
, Dongyuan Wang
, Xiaodong Shi
, Jingxu Li
, Yue Ma
, Yanding Wang
, Tingting Li
, Jianing Zhang
, Rongtong Zhao
, Zhiqiang Yu
, Feng Yin^*
, Zigang Li

^*Corresponding author for this work

Peking University
Southern Medical University

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Herein, we report a unique siRNA-induced peptide co-assembly nanocarrier, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo. In a tumor xenograft nude mouse model, these siRNA-peptide nanospheres inhibited tumor volume growth by >60%.

Original language	English
Pages (from-to)	745-752
Number of pages	8
Journal	Materials Horizons
Volume	5
Issue number	4
DOIs	https://doi.org/10.1039/c8mh00392k
Publication status	Published - Jul 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c8mh00392k

Cite this

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title = "A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy",

abstract = "Herein, we report a unique siRNA-induced peptide co-assembly nanocarrier, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo. In a tumor xenograft nude mouse model, these siRNA-peptide nanospheres inhibited tumor volume growth by >60\%.",

author = "Wenjun Li and Dongyuan Wang and Xiaodong Shi and Jingxu Li and Yue Ma and Yanding Wang and Tingting Li and Jianing Zhang and Rongtong Zhao and Zhiqiang Yu and Feng Yin and Zigang Li",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

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doi = "10.1039/c8mh00392k",

language = "English",

volume = "5",

pages = "745--752",

journal = "Materials Horizons",

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TY - JOUR

T1 - A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

AU - Li, Wenjun

AU - Wang, Dongyuan

AU - Shi, Xiaodong

AU - Li, Jingxu

AU - Ma, Yue

AU - Wang, Yanding

AU - Li, Tingting

AU - Zhang, Jianing

AU - Zhao, Rongtong

AU - Yu, Zhiqiang

AU - Yin, Feng

AU - Li, Zigang

PY - 2018/7

Y1 - 2018/7

N2 - Herein, we report a unique siRNA-induced peptide co-assembly nanocarrier, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo. In a tumor xenograft nude mouse model, these siRNA-peptide nanospheres inhibited tumor volume growth by >60%.

AB - Herein, we report a unique siRNA-induced peptide co-assembly nanocarrier, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo. In a tumor xenograft nude mouse model, these siRNA-peptide nanospheres inhibited tumor volume growth by >60%.

UR - https://www.scopus.com/pages/publications/85049444949

U2 - 10.1039/c8mh00392k

DO - 10.1039/c8mh00392k

M3 - Article

AN - SCOPUS:85049444949

SN - 2051-6347

VL - 5

SP - 745

EP - 752

JO - Materials Horizons

JF - Materials Horizons

IS - 4

ER -

A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

Abstract

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