A simulation for proportional biological operational Mu-Circuit

Dechang Xu; Zhipeng Cai; Ke Liu; Xiangmiao Zeng; Yujing Ouyang; Cuihong Dai; Aiju Hou; Dayou Cheng; Jianzhong Li

doi:10.1007/978-3-319-08171-7_8

A simulation for proportional biological operational Mu-Circuit

Dechang Xu
, Zhipeng Cai
, Ke Liu
, Xiangmiao Zeng
, Yujing Ouyang
, Cuihong Dai
, Aiju Hou
, Dayou Cheng
, Jianzhong Li

Research output: Chapter in Book or Report/Conference proceeding › Conference Proceeding › peer-review

1 Citation (Scopus)

Abstract

To quantitatively control the expression of target gene is challenging but highly desired in practice. We design a device-Biological Proportional Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that we can control input-output proportionly by manipulating the RBS of hrpR, hrpS, tetR and output gene.

Original language	English
Title of host publication	Bioinformatics Research and Applications - 10th International Symposium, ISBRA 2014, Proceedings
Publisher	Springer Verlag
Pages	81-91
Number of pages	11
ISBN (Print)	9783319081700
DOIs	https://doi.org/10.1007/978-3-319-08171-7_8
Publication status	Published - 2014
Externally published	Yes
Event	10th International Symposium on Bioinformatics Research and Applications, ISBRA 2014 - Zhangjiajie, China Duration: 28 Jun 2014 → 30 Jun 2014

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	8492 LNBI
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	10th International Symposium on Bioinformatics Research and Applications, ISBRA 2014
Country/Territory	China
City	Zhangjiajie
Period	28/06/14 → 30/06/14

Keywords

Modeling
Proportional regulation
Simulation

Access to Document

10.1007/978-3-319-08171-7_8

Cite this

Xu, D., Cai, Z., Liu, K., Zeng, X., Ouyang, Y., Dai, C., Hou, A., Cheng, D., & Li, J. (2014). A simulation for proportional biological operational Mu-Circuit. In Bioinformatics Research and Applications - 10th International Symposium, ISBRA 2014, Proceedings (pp. 81-91). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 8492 LNBI). Springer Verlag. https://doi.org/10.1007/978-3-319-08171-7_8

Xu, Dechang ; Cai, Zhipeng ; Liu, Ke et al. / A simulation for proportional biological operational Mu-Circuit. Bioinformatics Research and Applications - 10th International Symposium, ISBRA 2014, Proceedings. Springer Verlag, 2014. pp. 81-91 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

@inproceedings{7f90be3050c04691b82568c435f0e5df,

title = "A simulation for proportional biological operational Mu-Circuit",

abstract = "To quantitatively control the expression of target gene is challenging but highly desired in practice. We design a device-Biological Proportional Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that we can control input-output proportionly by manipulating the RBS of hrpR, hrpS, tetR and output gene.",

keywords = "Modeling, Proportional regulation, Simulation",

author = "Dechang Xu and Zhipeng Cai and Ke Liu and Xiangmiao Zeng and Yujing Ouyang and Cuihong Dai and Aiju Hou and Dayou Cheng and Jianzhong Li",

year = "2014",

doi = "10.1007/978-3-319-08171-7\_8",

language = "English",

isbn = "9783319081700",

series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

publisher = "Springer Verlag",

pages = "81--91",

booktitle = "Bioinformatics Research and Applications - 10th International Symposium, ISBRA 2014, Proceedings",

note = "10th International Symposium on Bioinformatics Research and Applications, ISBRA 2014 ; Conference date: 28-06-2014 Through 30-06-2014",

}

Xu, D, Cai, Z, Liu, K, Zeng, X, Ouyang, Y, Dai, C, Hou, A, Cheng, D & Li, J 2014, A simulation for proportional biological operational Mu-Circuit. in Bioinformatics Research and Applications - 10th International Symposium, ISBRA 2014, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 8492 LNBI, Springer Verlag, pp. 81-91, 10th International Symposium on Bioinformatics Research and Applications, ISBRA 2014, Zhangjiajie, China, 28/06/14. https://doi.org/10.1007/978-3-319-08171-7_8

A simulation for proportional biological operational Mu-Circuit. / Xu, Dechang; Cai, Zhipeng; Liu, Ke et al.
Bioinformatics Research and Applications - 10th International Symposium, ISBRA 2014, Proceedings. Springer Verlag, 2014. p. 81-91 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 8492 LNBI).

Research output: Chapter in Book or Report/Conference proceeding › Conference Proceeding › peer-review

TY - GEN

T1 - A simulation for proportional biological operational Mu-Circuit

AU - Xu, Dechang

AU - Cai, Zhipeng

AU - Liu, Ke

AU - Zeng, Xiangmiao

AU - Ouyang, Yujing

AU - Dai, Cuihong

AU - Hou, Aiju

AU - Cheng, Dayou

AU - Li, Jianzhong

PY - 2014

Y1 - 2014

N2 - To quantitatively control the expression of target gene is challenging but highly desired in practice. We design a device-Biological Proportional Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that we can control input-output proportionly by manipulating the RBS of hrpR, hrpS, tetR and output gene.

AB - To quantitatively control the expression of target gene is challenging but highly desired in practice. We design a device-Biological Proportional Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that we can control input-output proportionly by manipulating the RBS of hrpR, hrpS, tetR and output gene.

KW - Modeling

KW - Proportional regulation

KW - Simulation

UR - https://www.scopus.com/pages/publications/84958547687

U2 - 10.1007/978-3-319-08171-7_8

DO - 10.1007/978-3-319-08171-7_8

M3 - Conference Proceeding

AN - SCOPUS:84958547687

SN - 9783319081700

T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

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BT - Bioinformatics Research and Applications - 10th International Symposium, ISBRA 2014, Proceedings

PB - Springer Verlag

T2 - 10th International Symposium on Bioinformatics Research and Applications, ISBRA 2014

Y2 - 28 June 2014 through 30 June 2014

ER -

Xu D, Cai Z, Liu K, Zeng X, Ouyang Y, Dai C et al. A simulation for proportional biological operational Mu-Circuit. In Bioinformatics Research and Applications - 10th International Symposium, ISBRA 2014, Proceedings. Springer Verlag. 2014. p. 81-91. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-319-08171-7_8

A simulation for proportional biological operational Mu-Circuit

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Keywords

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