A novel simian retrovirus subtype discovered in cynomolgus monkeys (Macaca fascicularis)

Chih Ling Zao; Lisa Tomanek; Anthony Cooke; Ron Berger; Lingyan Yang; Chen Xie; Si Chen; Changjun Shi; Rong Rong

doi:10.1099/jgv.0.000601

A novel simian retrovirus subtype discovered in cynomolgus monkeys (Macaca fascicularis)

Chih Ling Zao^*
, Lisa Tomanek
, Anthony Cooke
, Ron Berger
, Lingyan Yang
, Chen Xie
, Si Chen
, Changjun Shi
, Rong Rong

^*Corresponding author for this work

VRL-San Antonio
VRL-China
Xi'an Jiaotong-Liverpool University

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A new simian retrovirus (SRV) subtype was discovered in China and the USA from Cambodianorigin cynomolgus monkeys. Histopathological examination from necropsied animals showed multifocal lymphoplasmacystic and histocytic inflammation. The complete genome sequences demonstrated that the US virus isolates were nearly identical (99.91–99.93%) and differed only slightly (99.13–99.16% identical) from the China isolate. Phylogenetic analysis showed that the new virus isolates formed a distinct branch of SRV-1 through -7, and therefore were named this subtype, SRV-8. This SRV-8 variant was also phylogenetically and serologically more closely related to SRV-4 than any other SRV subtype.

Original language	English
Article number	000601
Pages (from-to)	3017-3023
Number of pages	7
Journal	Journal of General Virology
Volume	97
Issue number	11
DOIs	https://doi.org/10.1099/jgv.0.000601
Publication status	Published - Nov 2016

Keywords

Complete genome sequence
Cynomolgus macaque
Phylogeny
Simian retrovirus 8
Simian retrovirus type D

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10.1099/jgv.0.000601

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title = "A novel simian retrovirus subtype discovered in cynomolgus monkeys (Macaca fascicularis)",

abstract = "A new simian retrovirus (SRV) subtype was discovered in China and the USA from Cambodianorigin cynomolgus monkeys. Histopathological examination from necropsied animals showed multifocal lymphoplasmacystic and histocytic inflammation. The complete genome sequences demonstrated that the US virus isolates were nearly identical (99.91{\textendash}99.93\%) and differed only slightly (99.13{\textendash}99.16\% identical) from the China isolate. Phylogenetic analysis showed that the new virus isolates formed a distinct branch of SRV-1 through -7, and therefore were named this subtype, SRV-8. This SRV-8 variant was also phylogenetically and serologically more closely related to SRV-4 than any other SRV subtype.",

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AU - Zao, Chih Ling

AU - Tomanek, Lisa

AU - Cooke, Anthony

AU - Berger, Ron

AU - Yang, Lingyan

AU - Xie, Chen

AU - Chen, Si

AU - Shi, Changjun

AU - Rong, Rong

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AB - A new simian retrovirus (SRV) subtype was discovered in China and the USA from Cambodianorigin cynomolgus monkeys. Histopathological examination from necropsied animals showed multifocal lymphoplasmacystic and histocytic inflammation. The complete genome sequences demonstrated that the US virus isolates were nearly identical (99.91–99.93%) and differed only slightly (99.13–99.16% identical) from the China isolate. Phylogenetic analysis showed that the new virus isolates formed a distinct branch of SRV-1 through -7, and therefore were named this subtype, SRV-8. This SRV-8 variant was also phylogenetically and serologically more closely related to SRV-4 than any other SRV subtype.

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KW - Phylogeny

KW - Simian retrovirus 8

KW - Simian retrovirus type D

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A novel simian retrovirus subtype discovered in cynomolgus monkeys (Macaca fascicularis)

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Keywords

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