1,4-Naphthoquinone Analogs and Their Application as Antibacterial Agents

Antimicrobial resistance threatens the effective prevention and treatment of an ever-increasing range of infections caused by different types of bacteria. Addressing antibacterial resistance and protecting human health requires multi-sectoral, long-acting, and professional administration. Sustainable investment in the R&D of antimicrobial drugs is one of the critical strategies for solving the current problem. Specifically, the development of novel effective drug candidates with a unique mode of action is essential for overcoming antibacterial resistance. 1,4-Naphthoquinone is a quinone derivative from naphthalene, one of the most important subclasses of quinone. 1,4-Naphthoquinones have been studied as potential candidates against various diseases, including cancer and malaria, and are a promising new compound that can treat bacterial infections. This review focuses on 1,4-naphthoquinone analogs for their activity against bacteria.