Investigating the Genetic Interaction of Phasmarhabditis Nematodes as a Potential Biological Control Agent against Angiostrongylus Transmission in Gastropods

阻断广州管圆线虫传播的潜在生物防治剂拟蛞蝓线虫的遗传互作研究

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This study aims to investigate whether Chinese Phasmarhabditis species can interfere with the development of A. cantonensis larvae during the snail host phase, providing insights for a novel A. cantonensis control strategy. Additionally, we aim to explore the phylogenetic relationship between Angiostrongylus and Phasmarhabditis nematodes to assess the suitability of Phasmarhabditis as a model organism for parasitological research of important nematode species. The following objectives will be pursued: (I) assess the impact of Phasmarhabditis co-infection on A. cantonensis larval development in Pomacea canaliculata snails; (II) generate a comparative proteomic profile of A. cantonensis and Phasmarhabditis nematodes during their gastropod host phase to identify shared and divergent gene expression patterns linked to gastropod parasitism; (iii) investigate the phylogenetic relationship between Angiostrongylus and Phasmarhabditis nematodes by sequencing their mitochondrial genomes and ribosomal RNA (rRNA) subunits.