This research is based on the coupling method of Computational Fluid Dynamics (CFD) and soil dynamics, conducting numerical simulation of the seabed dynamic response of marine structures under combined wave-current loads. It focuses on revealing the spatiotemporal evolution laws of wave pressure, structural wave forces, and seabed pore water pressure, and establishing a prediction model for the critical conditions of soil liquefaction around pile foundations. The research results can provide a multi-physics field coupling analysis method and a basis for early warning of soil dynamic disasters for the design optimization of engineering structures such as deep-sea platforms and submarine pipelines.