Projects per year
Personal profile
Personal profile
Dr Yuewei Xu did his undergrad study in the Department of Biological Sciences at XJTLU (2013-2017) and then completed MRes (Cancer Biology) and PhD study at Imperial College London. During the PhD, his research focused on developing novel combination therapies for PARP inhibitor resistant ovarian cancer. Later, he worked in WuXi Biologics (Shanghai) for 1.5 years and led a team of four scientists. His group has helped multiple clients developing cell lines, producing biopharmaceuticals, and optimizing culture process for large scale production.
Driven by passion for teaching and research, Yuewei came back to academia. He felt studying at XJTLU was a life-changing experience and he hope more students can feel the same.
Here at XJTLU, Yuewei's research focuses on cancer biology from following perspectives: (1) exploring synthetic lethality interactions using drug combination screens; (2) studying how alternative RNA splicing may affect cellular response to DNA damage and other stresses; (3) designing novel inhibitors targeting splicing factors, using emerging strategies such as molecular glue or PROTACs.
Over the years of study and research, Yuewei has used a range of functional assays that are very useful for cancer research, such as cell growth, apoptosis, cell cycle, DNA damage, RNA splicing, 3D cell invasion assays, and synergy analysis.
If you are interested in working with Yuewei, please feel free to send an email or visit office LSN1121 for a chat.
Office hours (for AY26/27):
Thursday (17:00 - 18:00)
(May be adjusted in case of time conflicts.)
Awards and honours
- 2025 Jiangsu ShuangChuang Doctoral Award (双创博士)
- 2025 SURF Excellent Poster (Lead by students Yitong Pan, Shuo Wanyan, and Yuze Ma)
- 2024 Poster Award (2nd place), ZOMES meeting, Shenzhen China.
- 2018-2022 Full PhD scholarship by China Scholarship Council & Imperial College London.
- 2017 Top Project Award for BSc thesis, Royal Society of Biology, UK
- 2017 Best Performance in FYP, XJTLU, China
- 2017 Best Overall Academic Performance, XJTLU, China
- 2016 National Scholarship by the Ministry of Education, China
- 2014-2016 XJTLU scholarships (3 times)
Experience
| 2025.09 - present | Programme Director of BEng/BSc Biopharmaceuticals |
| 2024.09 - present | Assistant Professor, XJTLU |
| 2023.02 - 2024.08 | Principal Scientist II (Elite Program), WuXi Biologics |
Teaching
APH314 Final Year Project (module coordinator)
APH428 Quality Systems and Standards (module leader)
APH430 Quality Assurance for Drugs and Biologics (module leader)
APH424 Regulatory of Pharmaceutical and Biological Products (co-teaching)
APH429 Research Ethics and Research Methodology (co-teaching)
APH438 Advanced Pharmacotherapy (co-teaching)
Research interests
RNA splicing in cancer
Drugs (PROTACs or inhibitors) for splicing factors
Novel combination therapies and synthetic lethality
Related documents
Education/Academic qualification
PGCert (Postgraduate Certificate in Teaching and Supporting Learning in Higher Education), University of Liverpool
Award Date: 27 Aug 2026
PhD, Cancer Biology, Imperial College London
7 Jan 2019 → 1 Feb 2023
Award Date: 1 Feb 2023
Master, MRes Cancer Biology (Distinction), Imperial College London
30 Sept 2017 → 30 Sept 2018
Award Date: 30 Sept 2018
Bachelor, BSc Biological Sciences (Ranked top 1), Xi'an Jiaotong-Liverpool University
1 Sept 2013 → 30 Jul 2017
Award Date: 30 Jul 2017
External positions
Member, European Society for Medical Oncology
Aug 2026 → …
Research areas
- Cancer Biology
- Targeted Therapy
- RNA splicing
- Drug combination
- DNA damage
- Molecular glue
Keywords
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
- Cancer Biology
- DNA damage
- Apoptosis
- RNA splicing
- Molecular glue / PROTAC
- R Medicine (General)
- Drug development
Person Types
- Staff
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
Dive into the research topics where Yuewei Xu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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From Student-Generated Data to Industry Applications: A Cross-Level Syntegrative Education Initiative in AI Learning
Cao, N. (PI), Huang, B. (Team member), Huang, L. (Team member), Xu, Z. (Team member), Liu, J. (Team member), Liu, J. (Team member), Liu, Y. (Team member), Zhu, F. (Team member), Zhao, Y. (Team member), Ji, Q. (Team member), Yang, R. (Team member), Huo, Y. (Team member), Jin, A. (Team member), Yao, L. (Team member), He, T. (Team member), Xu, Y. (Team member), Zhao, J. (Team member), Li, T. (Team member), Meng, F. (Team member) & Ding, Y. (Team member)
6/07/26 → 31/08/28
Project: Internal Research Project
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EASE: QuizWizard & XamStar: AI agents for programme-level assessment standardisation and student-centered learning
Xu, Y. (PI), Li, K. (CoPI), Gu, J. (Team member), Wang, B. (Team member), Snyder, A. (Team member), Liu, X. (Team member) & Song, J. (Team member)
24/06/26 → 25/12/26
Project: Internal Research Project
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Targeting RNA splicing as a novel strategy to treat medulloblastoma
Xu, Y. (PI)
1/07/25 → 30/06/28
Project: Internal Research Project
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Single-Molecule Single-Cell Imaging and Analysis Innovation Platform
Ruan, G. (PI), Zhang, X. (Team member), Wang, Y. (Team member), Zhou, Z. (Team member), Zhang, J. (Team member), Ding, D. (Team member), Ling, C. (Team member), Wu, Q. (Team member), Xu, P. (Team member), Ho, J. (Team member), Cheng, K. (Team member), Song, J. (Team member), Guo, B. (Team member), Wu, S. (Team member), Wang, J. (Team member), Sun, Y. (Team member), Lu, T. (Team member), Li, T. (Team member), Xu, Y. (Team member), Huang, D. (Team member), Cao, S. (Team member), Leng, J. (Team member) & Wen, X. (Team member)
1/10/24 → 30/09/26
Project: Governmental Research Project
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Exploiting the polypharmacology of alectinib for synergistic RNA splicing disruption with RBM39 degraders
Ma, Y., Poon, E., Jin, C., Martins da Costa, B., Xu, Y., Quazi, S., Zourdoumis, N., Wickremesinghe, C., Chesler, L., Keun, H. C. & Nijhuis, A., 27 Jan 2026, In: Cell Reports. 45, 1, p. 116784 1 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Management of pediatric brain arteriovenous malformations in hybrid operating room: treatment allocation, intraoperative angiographic findings, and functional outcomes
Song, K., Xu, Y., Liu, P., Li, Z., Shi, Y., Chen, C.-J., Tian, Y., Wang, X., Qiu, T. & Zhu, W., Dec 2026, In: Journal of Clinical Neuroscience. 154, p. 112286Research output: Contribution to journal › Article › peer-review
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RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combination
Gruet, M., Xu, Y., An, L., Ma, Y., Balcells, C., Tyson, K., Evangelista, L. C., Spear, S., Xu, Y., McKinney, F., Babuta, J., Bray, C., Wickremesinghe, C., Siskos, A. P., Nijhuis, A. M., Tate, E. W., McNeish, I. A., Benito, A. & Keun, H. C., Dec 2026, In: Communications Biology. 9, 1, 6.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
PTEN Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Spear, S., Le Saux, O., Mirza, H. B., Iyer, N., Tyson, K., Freile, F. G., Walton, J. B., Woodman, C., Jarvis, S., Ennis, D. P., Hernandez, C. A., Xu, Y., Spiliopoulou, P., Brenton, J. D., Costa-Pereira, A. P., Cook, D. P., Vanderhyden, B. C., Keun, H. C., Triantafyllou, E. & Arnold, J. N. & 1 others, , Nov 2024, In: Cancer Research. 84, 22, p. 3772-3787 16 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
Xu, Y., Spear, S., Ma, Y., Lorentzen, M. P., Gruet, M., McKinney, F., Xu, Y., Wickremesinghe, C., Shepherd, M. R., McNeish, I., Keun, H. C. & Nijhuis, A., 31 Oct 2023, In: Cell Reports. 42, 10, 113307.Research output: Contribution to journal › Article › peer-review
Open Access40 Citations (Scopus)
Activities
- 1 Presentation at conference/workshop/seminar
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Exploiting RNA splicing dependency in cancer with DCAF15-dependent molecular glues
Xu, Y. (Speaker)
25 Aug 2026Activity: Talk or presentation › Presentation at conference/workshop/seminar