Projects per year
Personal profile
Personal profile
Yuan is a trained virologist with extensive research experience in drug discovery. Over the past decade, her primary focus has been on developing novel anti - infection therapies. After completing her postdoctoral training at Emory University, she began her career at Boehringer Ingelheim, rising through the ranks from a bench - work scientist to a senior scientist, principal scientist, and project leader.
She initiated several crucial drug discovery projects and successfully steered them into the company's portfolio. Moreover, during her professional track in the industry, she published several high - impact papers as corresponding author, significantly enhancing her standing in the scientific community.
Simultaneously, she established a broad network and exerted considerable influence within the scientific realm. She was in charge of Boehringer Ingelheim's external funding platform and facilitated a strategic collaboration with Tsinghua University.
After ten productive years at Boehringer Ingelheim, she joined XJTLU last month as an associate professor. She will continue her research endeavors in anti - infection drug discovery and vaccine development.
Education/Academic qualification
PhD, Institute Pasteur of Shanghai, Chinese Academy of Sciences
1 Sept 2006 → 10 Jan 2012
Award Date: 10 Jan 2012
Research areas
- novel antiviral therapy
- cancer vaccine
- oncolytic virus
Person Types
- Staff
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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Development of SMAC Mimetics as Novel Host-Targeted Anti-Influenza Therapeutics: Mechanism Elucidation, Lead Optimization, and Preclinical Evaluation
He, Y. (PI)
1/01/26 → 31/12/28
Project: Internal Research Project
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Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway
Ng, I. I., Zhang, Z., Xiao, K., Ye, M., Tian, T., Zhu, Y., He, Y., Chu, L. & Tang, H., 24 Jun 2025, In: Cell Reports. 44, 6, 115733.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral
Mei, M., Impagnatiello, M. A., Jiao, J., Reiser, U., Tontsch-Grunt, U., Zhang, J., Nicklin, P., Yu, B., Wang, Y., He, Y. & Tan, X., 1 Jan 2024, In: Protein and Cell. 15, 1, p. 69-75 7 p.Research output: Contribution to journal › Letter › peer-review
Open Access3 Citations (Scopus) -
Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells
Yuan, L., Ma, X., Yang, Y., Qu, Y., Li, X., Zhu, X., Ma, W., Duan, J., Xue, J., Yang, H., Huang, J. W., Yi, S., Zhang, M., Cai, N., Zhang, L., Ding, Q., Lai, K., Liu, C., Zhang, L. & Liu, X. & 13 others, , 28 Sept 2023, In: Nature. 621, 7980, p. 840-848 9 p.Research output: Contribution to journal › Article › peer-review
Open Access118 Citations (Scopus) -
Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver
Huang, X., Li, X., An, H., Wang, J., Ding, M., Wang, L., Li, L., Ji, Q., Qu, F., Wang, H., Xu, Y., Lu, X., He, Y. & Zhang, J. R., Aug 2022, In: PLoS Pathogens. 18, 8, e1010693.Research output: Contribution to journal › Article › peer-review
Open Access143 Citations (Scopus) -
New Targets for Antiviral Therapy: Inhibitory Receptors and Immune Checkpoints on Myeloid Cells
Liu, Y., Nicklin, P. & He, Y., Jun 2022, In: Viruses. 14, 6, 1144.Research output: Contribution to journal › Review article › peer-review
Open Access1 Citation (Scopus)