Projects per year
Personal profile
Personal profile
Dr. Shen received his PhD in Genetics and Genomics and MPH in Public Health Policy and Management from the University of Florida (2018). Subsequently, he conducted postdoctoral research in Human Genetics at Harvard Medical School and the Broad Institute of MIT and Harvard.
His research program spans two domains: (1) elucidating epigenetic control of gene expression through genome editing technologies, and (2) developing innovative epigenetic reprogramming approaches for gene therapy specifically targeting blood genetic diseases, such as sickle cell disease and thalassemia. Dr. Shen has authored research papers in Nature Communications, Molecular and Cellular Biology, PLOS Genetics, and Molecular Therapy - Nucleic Acid etc.
In addition to his academic pursuits, Dr. Shen possesses extensive experience in innovation and entrepreneurship. He is dedicated to translating cutting-edge biomedical innovations into practical solutions for some of the most challenging human health issues, including genetic diseases, cancer, and aging.
Research interests
Gene Therapy and Cell Reprogramming to Reverse Cellular Aging
Engineering of AAV Gene Therapy Delivery Vector
Establishment of Epigenome Editing System for Gene Expression Modulation
Teaching
BIO109 Developmental Biology, 2025-present
BIO304 Biotechnology and Society, 2024-present
BIO401 Research Methods in Biotechnology, 2023-present
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Postdoc in Human Genetics, Harvard Medical School and Broad Institute of MIT and Harvard, 2018-2021
Ph.D. in Genetics and Genomics, University of Florida, 2018
M.P.H in Public Health Policy and Management, University of Florida, 2018
Research areas
- Gene Therapy
- Aging Reversal
- Cell Reprogramming
- Genome Editing
Person Types
- Staff
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CRISPR Activation for Epigenetic Reprogramming to Reverse Cellular Aging
Shen, Y. (PI)
1/09/24 → 31/08/27
Project: Governmental Research Project
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CRISPR Activation for Epigenetic Reprogramming to Reverse Cellular Aging
Shen, Y. (PI)
1/07/24 → 30/06/27
Project: Internal Research Project
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Student performance and perceptions in the Global Classroom Initiative
Fendos, J. (PI), Raju, S. (Team member), Shen, Y. (Team member), Kam, A. (Team member) & Yap, W. H. (Team member)
17/04/24 → 31/12/26
Project: Collaborative Research Project
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CRISPR Activation for Epigenetic Reprogramming to Reverse Cellular Aging
Shen, Y. (PI)
Project: Governmental Research Project
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A unified model of human hemoglobin switching through single-cell genome editing
Shen, Y., Verboon, J. M., Zhang, Y., Liu, N., Kim, Y. J., Marglous, S., Nandakumar, S. K., Voit, R. A., Fiorini, C., Ejaz, A., Basak, A., Orkin, S. H., Xu, J. & Sankaran, V. G., 1 Dec 2021, In: Nature Communications. 12, 1, 4991.Research output: Contribution to journal › Article › peer-review
Open Access28 Citations (Scopus) -
Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing
Shen, Y., Li, R., Teichert, K., Montbleau, K. E., Verboon, J. M., Voit, R. A. & Sankaran, V. G., 11 Oct 2021, In: PLoS Genetics. 17, 10, e1009835.Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (Scopus) -
Erratum: Identification of a novel enhancer/ chromatin opening element associated with high-level γ-globin gene expression (Molecular and Cellular Biology (2018) 38:19 (e00197-18) DOI: 10.1128/MCB.00197-18)
Shen, Y., Bassett, M. A., Gurumurthy, A., Nar, R., Knudson, I. J., Guy, C. R., Perez, A., Mellen, R. W., Ikeda, M., Hossain, M. A., Huang, S., Igarashi, K. & Bungert, J., 2019, In: Molecular and Cellular Biology. 39, 11, e0016819.Research output: Contribution to journal › Comment/debate
Open Access2 Citations (Scopus) -
Phase Separation and Transcription Regulation: Are Super-Enhancers and Locus Control Regions Primary Sites of Transcription Complex Assembly?
Gurumurthy, A., Shen, Y., Gunn, E. M. & Bungert, J., Jan 2019, In: BioEssays. 41, 1, 1800164.Research output: Contribution to journal › Article › peer-review
Open Access32 Citations (Scopus) -
Computational design and experimental characterization of a novel β-common receptor inhibitory peptide
Kilar, C. R., Sekharan, S., Sautina, L., Diao, Y. P., Keinan, S., Shen, Y., Bungert, J., Mohandas, R. & Segal, M. S., Jun 2018, In: Peptides. 104, p. 1-6 6 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus)
Activities
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Hong Kong Centre for Translational Stem Cell Biology
Yong Shen (Visiting researcher)
16 Jul 2025Activity: Research visit
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International Society for Stem Cell Research 2025 Annual Meeting
Yong Shen (Participant)
13 Jun 2025Activity: Participating in or organising an event › Participating in an event e.g. a conference, workshop, …
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Guiding SURF student Beatrice Valerie Basuki on Cell Reprogramming to Reverse Aging
Yong Shen (Supervisor)
Jun 2025 → Aug 2025Activity: Supervision › Completed SURF Project
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Guiding SURF student Junqi Qian on Cell Reprogramming to Reverse Aging
Yong Shen (Supervisor)
Jun 2025 → Aug 2025Activity: Supervision › Completed SURF Project