Projects per year
Personal profile
Personal profile
Dr. Zhang received her PhD degree in Biochemistry from Duke University under the direction of Dr. Tao-shih Hsieh and completed her postdoctoral training at the University of California, Berkeley, under the guidance of Dr. David G. Drubin. She was appointed as an associated professor and Ph.D. supervisor at Peking University and Capital Medical University, working on molecular mechanisms of membrane trafficking in neurons and glia, as well as neurodegenerative diseases. Dr. Zhang joined the Academy of Pharmacy, Xi’an Jiaotong-Liverpool University in Oct., 2021. While continuing her endeavor in mechanistic studies, her current research focuses on identification of potential drug targets and novel therapeutic interventions in neurodegenerative diseases.
Dr. Zhang is an expert in membrane trafficking and neurodegenerative diseases. She has published papers in EMBO Rep, J Neurosci, Glia, Cell Mol Life Sci, FASEB J, Mol Neurobiol, Front Cell Neurosci, J Neurochem, etc., as correspondence author. She has been awarded three general programs from the National Natural Science Foundation of China and one key program from the Beijing Natural Science Foundation. Dr. Zhang welcomes interdisciplinary collaborations and encourages motivated undergraduate and graduate students majoring in Biology or related disciplines to join her research group. A funded PhD studentship is currently available: https://www.xjtlu.edu.cn/wp-content/uploads/2025/05/Xi_Zhang_PhD_Studentship_Advert_Doc_Fees-only_Scholarship.pdf
Research interests
Novel Drug Targets and Therapeutic Interventions
Membrane Trafficking
Neurodegenerative Diseases
Experience
Senior Associate Professor, Academy of Pharmacy, XJTLU, 2021-present
Associate Professor, Beijing Institute of Brain Disorders, Capital Medical University, 2013-2021
Associate Professor, Institute of Molecular Medicine, Peking University, 2006-2013
Postdoctoral Research Fellow and Associate Specialist, University of California, Berkeley, 1999-2006
Teaching
APH111 Practical Molecular Biology for Pharmacy
APH218 Principles of Pharmacology
APH202 Pharmacology
APH406 Advanced Pharmacology
APH002 Introduction to Basic Science of Medicine
Advanced Physiology, graduate course at CCMU
Membrane Trafficking Journal Club, graduate course at IMM, PKU
Awards and honours
2022 Jiangsu Innovation Entrepreneurship PhD (World Famous Universities)
2008 PG Teacher’s Award
2002-2005 Postdoctoral Fellowship from American Cancer Society
1996 First Prize in Carl Zeiss Imaging Contest
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Ph.D. in Biochemistry, Duke University, 1993-1999
B.A. in Biochemistry, University of Texas, Austin, 1991-1993
Undergraduate Program in Chemistry, Fudan University, 1988-1991
Research areas
- Neurotransmission
- Neuroinflammation
- Parkinson's Disease
Keywords
- Q Science (General)
- Synaptic vesicle recycling
- Neuroinflammation
- Parkinson's Disease
Person Types
- Staff
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Single-Molecule Single-Cell Imaging and Analysis Innovation Platform
Ruan, G. (PI), Zhang, X. (Team member), Wang, Y. (Team member), Zhou, Z. (Team member), Zhang, J. (Team member), Ding, D. (Team member), Ling, C. (Team member), Wu, Q. (Team member), Xu, P. (Team member), Ho, J. (Team member), Cheng, K. (Team member), Song, J. (Team member), Guo, B. (Team member), Wu, S. (Team member), Wang, J. (Team member), Sun, Y. (Team member), Lu, T. (Team member), Li, T. (Team member), Xu, Y. (Team member), Huang, D. (Team member), Cao, S. (Team member), Leng, J. (Team member) & Wen, X. (Team member)
1/10/24 → 30/09/26
Project: Governmental Research Project
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Jiangsu Province Higher Education Key Laboratory of Cell Therapy Nanoformulation (Construction)
Ruan, G. (PI), Lee, M. H. (Team member), Wu, Q. (Team member), Lu, T. (Team member), Xu, P. (Team member), Loo, S. (Team member), Sun, Y. (Team member), Kam, A. (Team member), Liu, X. (Team member), Wen, X. (Team member), Zhang, J. (Team member), Wang, M. (Team member), Xu, M. (Team member), Cheng, K. (Team member), Zhang, X. (Team member), Song, J. (Team member), Guo, B. (Team member), Wang, Y. (Team member), Wang, J. (Team member), Wu, S. (Team member), Yang, J. (Team member), Fu, L. (Team member), Zhang, J. (Team member), Qiao, Y. (Team member), Chen, Y. (Team member), Li, T. (Team member), Zhan, T. (Team member), Wan, Y. (Team member), He, Z. (Team member), Cheng, Y. (Team member), Leng, J. (Team member), Qi, M. (Team member), Ho, J. (Team member), Sun, Y. (Team member), Zhang, N. (Team member), Soe, H. M. S. H. (Team member), Ling, C. (Team member), Zhou, H. (Team member), Huang, D. (Team member) & Gu, J. (Team member)
1/07/24 → 30/06/27
Project: Governmental Research Project
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SIP High-quality Innovation Platform for chronic diseases
Fu, L. (PI), Zhang, X. (Team member), Liu, X. (Team member), Wang, R. (Team member), Li, Y. (Team member), Ruan, G. (Team member), Chen, J. (Team member), Zhang, J. (Team member), Lee, M. H. (Team member), Wang, Y. (Team member), Chen, Y. (Team member), Guo, J. (Team member), Hong, M. (Team member), Yue, Y. (Team member), Guo, H. (Team member), Xu, H. (Team member), Gu, J. (Team member), Wang, Y. (Team member), Yang, D. (Team member) & Cheng, J. (Team member)
1/09/22 → 30/08/26
Project: Governmental Research Project
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In vivo function of synaptotagmin-11 in microglia-mediated neuroinflammation in a Parkinson's disease model
Zhang, X. (PI), Zhang, Y. (Team member), Li, Y. (Team member), Yang, Y. (Team member) & Yang, D. (Team member)
1/09/22 → 31/08/25
Project: Internal Research Project
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Parkinson's Disease: Mechanisms, New Technologies, and Potential Therapeutic Interventions
Zhang, C. X., 2023, In: Frontiers in Aging Neuroscience.Research output: Contribution to journal › Editorial
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Synaptotagmin-11 Inhibits Synaptic Vesicle Endocytosis via Endophilin A1
Wang, Y., Zhu, Y., Li, W., Yan, S., Li, C., Ma, K., Hu, M., Du, C., Fu, L., Sun, J. & Zhang, C. X., 6 Sept 2023, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 43, 36, p. 6230-6248 19 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Synaptotagmin-11 regulates immune functions of microglia in vivo
Zhang, F., Yang, D., Li, J., Du, C., Sun, X., Li, W., Liu, F., Yang, Y., Li, Y., Fu, L., Li, R. & Zhang, C. X., Dec 2023, In: Journal of Neurochemistry. 167, 5, p. 680-695 16 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Combination of liquid crystal and deep learning reveals distinct signatures of Parkinson's disease-related wild-type α-synuclein and six pathogenic mutants
Yang, X., Zhao, X., Zhao, H., Liu, F., Zhang, S., Zhang, C. X. & Yang, Z., 17 Jan 2022, In: Chemistry - An Asian Journal. 17, 2, e202101251.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
SNARE Proteins Mediate α-Synuclein Secretion via Multiple Vesicular Pathways
Zhao, X., Guan, Y., Liu, F., Yan, S., Wang, Y., Hu, M., Li, Y., Li, R. & Zhang, C. X., Jan 2022, In: Molecular Neurobiology. 59, 1, p. 405-419 15 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus)
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Molecular mechanism of Syt11 regulation of a neuronal endocytic protein
Zhang, X. (Supervisor)
2023Activity: Supervision › Completed SURF Project
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Peptides Targeting Alpha-Synuclein Aggregation Associated with Parkinson’s Disease
Zhang, X. (Supervisor)
2023Activity: Supervision › Master Dissertation Supervision
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Frontiers in Aging Neuroscience (Journal)
Zhang, X. (Editor)
2023Activity: Peer-review and editorial work of publications › Editorial work
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Mapping synaptotagmin-11 binding site on a neuronal endocytic protein
Zhang, X. (Supervisor)
23 Jun 2022 → 26 Aug 2022Activity: Supervision › Completed SURF Project
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Nature Communications (Journal)
Zhang, X. (Reviewer)
2022 → …Activity: Peer-review and editorial work of publications › Editorial work