Projects per year
Personal profile
Personal profile
Dr. Qiang Wu received his PhD degree from Shanghai Institute of Nutrition and Health (original name: Institute of Health Sciences, Shanghai Institutes for Biological Sciences), Chinese Academy of Sciences. He investigated the efficacy and mechanisms of stem cell-derived cardiovascular cells and extracellular vesicles in repairing infarcted hearts during PhD study. He has experience on research and development (R&D) in drug discovery, having worked at a large CRO company and biotechs. Before joining Xi'an Jiaotong-Liverpool University, he served as Associate Director & Project Leader in gene therapy, responsible for project evaluation, discovery and development of new AAV-based gene therapy products in rare genetic diseases. Currently, Dr. Wu is interested in extracellular vesicles (EVs), gene therapy and stem cells. He focuses on analysis and engineering of EVs for drug delivery, and gene therapy development for some disease.
Research interests
Analysis and engineering of extracellular vesicles (EVs)/exosomes to improve drug targeting and loading capacity for drug delivery
Genetic disease and gene therapy development
Experience
Senior Scientist to Associate Director in Gene Therapy, Lingyi Biotech Co., Ltd., 2021-2023
Scientist, HD Biosciences Co., Ltd. (HDB), a WuXi AppTec company, 2019-2021
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Chinese Academy of Sciences, 2019
BSc, Anhui Normal University, 2012
Research areas
- Gene Therapy
- Exosome
- Extracellular Vesicle
- Adeno-associated Virus (AAV)
- Biologic Drug Delivery
Person Types
- Staff
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Collaborations and top research areas from the last five years
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Projects
- 6 Active
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Mechanisms of extracellular vesicles derived from human pluripotent stem cells and their cardiac lineage cells for cardiac repair and enhancement of efficacy
Wu, Q. (PI)
1/01/25 → 31/12/27
Project: Governmental Research Project
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Single-Molecule Single-Cell Imaging and Analysis Innovation Platform
Ruan, G. (PI), Zhang, X. (Team member), Wang, Y. (Team member), Zhou, Z. (Team member), Zhang, J. (Team member), Ding, D. (Team member), Ling, C. (Team member), Wu, Q. (Team member), Xu, P. (Team member), Ho, J. (Team member), Cheng, K. (Team member), Song, J. (Team member), Guo, B. (Team member), Wu, S. (Team member), Wang, J. (Team member), Sun, Y. (Team member), Lu, T. (Team member), Li, T. (Team member), Xu, Y. (Team member), Huang, D. (Team member), Cao, S. (Team member), Leng, J. (Team member) & Wen, X. (Team member)
1/10/24 → 30/09/26
Project: Governmental Research Project
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An investigation into a novel gene therapy strategy using extracellular vesicles to encapsulate adeno-associated viruses, aimed at overcoming interference from pre-existing neutralizing antibodies
Wu, Q. (PI), Lu, T. (Team member), Zhan, T. (Team member), Wang, H. (Team member), Lin, Q. (Team member), Chen, Y. (Team member), Jiang, T. (Team member), Sheng, X. (Team member), Peng, Y. (Team member), Ma, M. (Team member) & Kong, J. (Team member)
1/09/24 → 31/08/27
Project: Governmental Research Project
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Engineering of extracellular vesicles derived from human pluripotent stem cells and their derived cells and their application in the treatment of myocardial infarction
Wu, Q. (PI)
1/07/24 → 30/06/27
Project: Internal Research Project
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An investigation into the mechanism of cardiac repair using a combination of extracellular vesicles from stem cells and their derived cells
Wu, Q. (PI), Xu, M. (Team member), Zhan, T. (Team member), Wang, H. (Team member), Ma, M. (Team member) & Kong, J. (Team member)
1/07/24 → 1/07/26
Project: Governmental Research Project
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Isolation and Characterization of Extracellular Vesicles Secreted from Human Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells
Wu, Q., Ke, M. X. & Yang, H. T., 2022, Methods in Molecular Biology. Humana Press Inc., p. 91-100 10 p. (Methods in Molecular Biology; vol. 2504).Research output: Chapter in Book or Report/Conference proceeding › Chapter › peer-review
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Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis
Wu, Q., Wang, J., Tan, W. L. W., Jiang, Y., Wang, S., Li, Q., Yu, X., Tan, J., Liu, S., Zhang, P., Tiang, Z., Chen, Z., Foo, R. S. Y. & Yang, H. T., 1 May 2020, In: Cell Death and Disease. 11, 5, 354.Research output: Contribution to journal › Article › peer-review
Open Access143 Citations (Scopus) -
Perspective on human pluripotent stem cell-derived cardiomyocytes in heart disease modeling and repair
Li, Q., Wang, J., Wu, Q., Cao, N. & Yang, H. T., 1 Oct 2020, In: Stem Cells Translational Medicine. 9, 10, p. 1121-1128 8 p.Research output: Contribution to journal › Review article › peer-review
Open Access21 Citations (Scopus) -
Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure
Wang, X., Wang, L., Wu, Q., Bao, F., Yang, H., Qiu, X. & Chang, J., 2019, In: ACS Applied Materials and Interfaces.Research output: Contribution to journal › Article › peer-review
77 Citations (Scopus) -
Human Embryonic Stem Cell-Derived Cardiovascular Progenitors Repair Infarcted Hearts Through Modulation of Macrophages via Activation of Signal Transducer and Activator of Transcription 6
Wang, J., Liu, M., Wu, Q., Li, Q., Gao, L., Jiang, Y., Deng, B., Huang, W., Bi, W., Chen, Z., Chin, Y. E., Paul, C., Wang, Y. & Yang, H. T., 10 Aug 2019, In: Antioxidants and Redox Signaling. 31, 5, p. 369-386 18 p.Research output: Contribution to journal › Article › peer-review
39 Citations (Scopus)
Activities
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Development of Stable Cas9-Expressing Cell Lines and Extracellular Vesicles for Genome Editing Applications
Wu, Q. (Supervisor)
1 Jul 2025 → 31 Aug 2025Activity: Supervision › Completed SURF Project
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International Society for Extracellular Vesicles (External organisation)
Wu, Q. (Member)
21 Jan 2025Activity: Membership › Membership of committee
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Identification of New Scaffold Proteins for Engineering Extracellular Vesicles
Wu, Q. (Supervisor)
1 Jul 2024 → 31 Aug 2024Activity: Supervision › Completed SURF Project
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International Society for Heart Research (External organisation)
Wu, Q. (Member)
1 Apr 2024Activity: Membership › Membership of committee
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Human Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells Repair Infarcted Myocardium via Secreted Exosomes
Wu, Q. (Speaker)
26 May 2018Activity: Talk or presentation › Presentation at conference/workshop/seminar