Personal profile
Personal profile
Dr. Kozo Hamada is an Associate Professor at the Department of Biological Sciences in the School of Science. He serves as the Principal Investigator (PI) leading his laboratory at Xian Jiaotong Liverpool University (XJTLU). He obtained his Ph.D. degree by the study of neurotransmitter serotonin and catecholamines at the University of Tokyo (Department of Biomedical Chemistry, Supervisor: Prof. Katsuji Takai). Over the past 20 years, he has dedicated his efforts to studying signal transductions, calcium signaling, and the structural biology of receptors and channels at institutions such as the University of Tokyo and RIKEN in Japan. His scientific interests encompass chemical signaling and related diseases, and he will focus on the development of new biomedical maneuvers to address human diseases, including neurodegenerative diseases and cancer. Dr. Hamada actively encourages students and collaborators to engage in his projects. For inquiries, you can reach him via email at Kozo.Hamada@xjtlu.edu.cn.
Selected Publications (*corresponding author)
- Yiying Li and *Hamada FEBS lett (2026) in press
- Miyamoto and *Hamada Mol Neurobiol (2025) 62, 13379-13389
- *Hamada et al. BBRC (2025) 766, 151875
- *Hamada et al. Ann Rev Physiol (2020) 82, 151-176
- Hamada et al. PNAS (2017) 114 (18), 4661-4666
- *Hamada et al. PNAS (2014) 111(38), E3966-75
- *Hamada et al. Science Signaling (2012) 5(225), pe24
- Higo, Hamada, et al. Neuron (2010) 68 (5), 865-78
Research interests
Protein Engineering
Signal Transduction
Protein Biogenesis
Neurodegenerative Disease
Protein Plasticity
Brain Biochemistry
Protein Crystallography
Calcium Signaling
Experience
2023-Present Associate Professor, XJTLU, China
2019-2023 Research Associate Professor, ShanghaiTech University, China
2019-Present Visiting researcher, Faculty of Science, Toho University, Japan
2018-2022 Researcher, Faculty of Pharmacy, Kindai Unversity, Japan
2010-2018 Research Scientist, Brain Science Institute, RIKEN, Japan
2003-2010 Researcher, Japan Science and Technology Agency, Japan
1998-2003 Research Scientist, Brain Science Institute, RIKEN, Japan
Teaching
BIO002 Introductory Biology
BIO105 Chemical Principles of Life
BIO113 Molecular Biology Techniques
BIO303 Final Year Project
BIO407 Research Project II
Related documents
Education/Academic qualification
Ph. D. Department of Biomedical Chemistry, Institute of International Health, The University of Tokyo
M. Sc. Department of Biochemistry and Nutrition, School of Health Science, The University of Tokyo
B. Sc. Department of Biochemistry and Nutrition, School of Health Science, The University of Tokyo
Research areas
- Biochemistry
- Neuroscience
- Physiology
- Biophysics
- Protein engineering
- Signal transduction
- Cell and Gene therapy
- Neurodegenerative Diseases
Person Types
- Staff
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Projects
- 2 Active
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Microproteins in the Endoplasmic Reticulum: Structure, Function, and Mechanisms
Hamada, K. (PI)
1/01/25 → 31/12/27
Project: Internal Research Project
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The mechanism of ammonia accumulation promotes liver cancer progression via calcium channel-mTORC2-SREBP1-lipogenesis dependent manner
Dai, W. (PI), Wang, S. (Team member), Chen, G. (Team member), Elkord, E. (Team member), Hamada, K. (Team member), Cheng, K. (Team member), Xu, J. (Team member), Huang, S. (Team member), Yang, C. (Team member), Ma, J. (Team member) & Bin, U. (Team member)
1/01/25 → 31/12/28
Project: Governmental Research Project
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Deciphering the multi-site phos-code of IRBIT underlying its binding to IP3R
Lin, Q., Yang, H., Feng, Q., Sumi, T., Hamada, K., Qian, Y., Bai, F., Mizutani, A. & Mikoshiba, K., 24 Apr 2026, In: Communications Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Genetically encoded lockdown of SERCA in the endoplasmic reticulum membrane arrests Ca2+ signaling through proximity-covalent crosslinking
Li, Y. & Hamada, K., 15 Apr 2026, In: FEBS Letters.Research output: Contribution to journal › Article › peer-review
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Long-range gating regulation by leaflet and autoinhibitory domains in mouse type 1 IP3 receptors
Hamada, K., Terauchi, A., Nakamura, K., Li, Y., Zhang, J., Li, J., Jiang, M., Chu, Y., Du, Z., Miyatake, H. & Mikoshiba, K., 20 Jun 2025, In: Biochemical and Biophysical Research Communications. 766, 151875.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Serotonergic Regulation of Photic Signaling of Ascorbate in the Rat Thalamus
Miyamoto, H. & Hamada, K., 16 Jun 2025, In: Molecular Neurobiology.Research output: Contribution to journal › Article › peer-review
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A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors
Lavik, A. R., McColl, K. S., Lemos, F. O., Kerkhofs, M., Zhong, F., Harr, M., Schlatzer, D., Hamada, K., Mikoshiba, K., Crea, F., Bultynck, G., Bootman, M. D., Parys, J. B. & Distelhorst, C. W., Apr 2022, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1869, 4, 119206.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus)
Activities
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Protein Engineering of Organelle-Targeted Biosensors
Hamada, K. (Supervisor)
16 Jun 2025 → 13 Sept 2025Activity: Supervision › Completed SURF Project
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IPAP meeting with the University of Liverpool Professor for the Ph.D candidate
Hamada, K. (Participant)
23 May 2025Activity: Participating in or organising an event › Organising an event e.g. a conference, workshop, …
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IPAP meeting with the University of Liverpool Professor for the Ph.D candidate
Hamada, K. (Participant)
20 May 2025Activity: Participating in or organising an event › Participating in an event e.g. a conference, workshop, …
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IPAP meeting with the University of Liverpool Professor for the Ph.D candidate
Hamada, K. (Participant)
19 May 2025Activity: Participating in or organising an event › Participating in an event e.g. a conference, workshop, …
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Master Thesis, Review
Hamada, K. (Participant)
16 May 2025Activity: Participating in or organising an event › Participating in an event e.g. a conference, workshop, …