Projects per year
Personal profile
Personal profile
Dr. Anjie Zheng is an Assistant Professor and Associate Research Fellow at the AoP, XJTLU. His research focuses on lipid-based drug delivery systems, tumor immunology, and translational nanomedicine, especially in the context of hard-to-treat solid tumors such as glioma.
Dr. Zheng holds extensive experience across academic research, industrial R&D, and clinical pharmacology, having previously contributed to the development of two innovative lipid-based immunotherapeutics:
- HF1K16 – the world’s first actively loaded ATRA liposomal immunomodulator targeting MDSCs, now under Phase II clinical trials.
- HF50 – the world’s first clinical-stage lipid-based T-cell engager (TCE) nanomedicine, which obtained clinical approval from the CDE in 2024.
Dr. Zheng was granted with fundings:
National Natural Science Foundation of China – Youth Project (PI)
China Postdoctoral Science Foundation Special Funding (17th Batch)
Now our group is actively involved in postgraduate training, undergraduate FYP supervision.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Shanghai Jiao Tong University
1 Sept 2016 → 30 Jun 2022
Award Date: 30 Jun 2022
Master, Shanghai Jiao Tong University
1 Sept 2013 → 30 Jun 2016
Award Date: 30 Jun 2016
External positions
Postdoctoral, Zhejiang University
5 Sept 2022 → 27 Nov 2024
Research areas
- Liposome
- Immuno-Oncology
Keywords
- QR180 Immunology
- Immunotherapy
- Myeloid-derived suppressor cells (MDSC)
Person Types
- Staff
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Collaborations and top research areas from the last five years
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Exploring the Application of All-Trans Retinoic Acid Liposomes in IDH-Mutant Glioma Therapy
Zheng, A. (PI)
1/07/25 → 30/06/27
Project: Internal Research Project
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CPSF: Exploring the tumor immune microenvironment in glioma-bearing mice through the "Window of Opportunity" and applying immunotherapy to glioma
Zheng, A. (PI)
1/01/25 → 31/12/26
Project: Governmental Research Project
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NSFC: Development and evaluation of biomaker in tumor immunotherapy under treatment with all-trans retinoic acid liposome
Zheng, A. (PI)
1/01/24 → 31/12/25
Project: Governmental Research Project
Research output
- 6 Article
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Characterization of mRNA-LNP structural features and mechanisms for enhanced mRNA vaccine immunogenicity
Wu, K., Xu, F., Dai, Y., Jin, S., Zheng, A., Zhang, N. & Xu, Y., Dec 2024, In: Journal of Controlled Release. 376, p. 1288-1299 12 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Enhanced anti-tumor efficacy of electroporation (EP)-mediated DNA vaccine boosted by allogeneic lymphocytes in pre-established tumor models
Shi, S., Zhang, L., Zheng, A., Xie, F., Kesse, S., Yang, Y., Peng, J. & Xu, Y., Dec 2024, In: Cancer Immunology, Immunotherapy. 73, 12, 248.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
MDSC-targeted liposomal all-trans retinoic acid suppresses mMdscs and improves immunotherapy in HBV infection
Kesse, S., Xu, Y., Shi, S., Jin, S., Ullah, S., Dai, Y., He, M., Zheng, A., Xu, F., Du, Z., Alolga, R. N. & Peng, J., 2024, In: Expert Opinion on Drug Delivery. 21, 2, p. 347-363 17 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Liposomal T cell engager and re-director for tumor cell eradication in cancer immunotherapy
Xie, F., Zhang, L., Shi, S., Zheng, A., Di, J., Jin, S., Miao, X., Wu, F., Chen, X., Zhang, Y., Wei, X. & Xu, Y., 2022, In: mAbs. 14, 1, 2115205.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Sustained Drug Release From Liposomes for the Remodeling of Systemic Immune Homeostasis and the Tumor Microenvironment
Zheng, A., Xie, F., Shi, S., Liu, S., Long, J. & Xu, Y., 12 Apr 2022, In: Frontiers in Immunology. 13, 829391.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus)