Evaluation of Phenylbutyric Acid in Alcohol-Induced Mucosal Injury: Validation, Cytoprotection, and Modulation of Antioxidant Pathways

  • Jie Zhang (Supervisor)

Activity: SupervisionCompleted SURF Project

Description

This study will investigate the protective effects of 4-phenylbutyric acid (4-PBA) in mucosal cell injury models. The relative strength and validation status of 4-PBA will be assessed, followed by the establishment of alcohol- and hydrogen peroxide-induced mucosal injury models. Optimized conditions will be applied for hydrogen peroxide injury, while established protocols will be used for alcohol-induced damage. The MTT assay will determine the non-toxic concentration range (1–800 μg), within which low, medium, and high concentrations will be tested for antioxidant activity (e.g., SOD activity, MDA levels).
Period6 Jul 202520 Aug 2025
Degree of RecognitionLocal