Description
In this project, a two-step method is used to synthesize carbohydrate ethers. The first step is to use diacetone glucose as raw material, etherize with bromoalkane, and obtain carbohydrate ether with acetonide protection groups. The second step is the de-protection under acidic conditions to remove the two acetonide groups, and the required carbohydrate ether can be synthesized after two steps. Since only one hydroxyl group on C3 is exposed from diacetone glucose as a starting material, it can be ensured that the bromoalkane etherize only with that hydroxyl group, so that the carbon chain will only be formed on C3 position of the glucose. This two-step method of synthesizing carbohydrate ethers can result in high-yield carbohydrate ethers products. In addition, we also tested the antibacterial activity of the product. The results showed that only the carbohydrate ethers with a carbon chain length of 12 had a certain inhibitory effect on S. aureus and the MIC value was 128 μg/ml, while the other carbohydrate ethers had no obvious inhibitory effect on S. aureus and E. coil.| Period | 23 Apr 2024 |
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| Examinee | Rui Zhou |
| Examination held at | |
| Degree of Recognition | International |